Deep_Learning
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A Probabilistic Perspective on Wasserstein-Based Evidential Uncertainty for Out-of-Distribution Segmentation
2026-10-07 14:03:45Arnold Brosch, Abdelrahman Eldesokey, Michael Felsberg, Kira MaagAbstract
Semantic segmentation networks operate on a fixed set of classes and therefore fail when out-of-distribution (OOD) objects appear during deployment, a critical limitation for safety-critical applications such as autonomous driving. Reliably identifying OOD objects requires well-calibrated epistemic uncertainty, yet common softmax-based confidence scores remain overconfident, while Bayesian alternatives such as Monte Carlo dropout or deep ensembles require costly repeated forward passes. Evidential Deep Learning (EDL) offers an efficient alternative by modeling class probabilities as a Dirichlet distribution learned from a single deterministic forward pass. Existing EDL formulations rely on Euclidean objectives that push predictions towards the simplex vertices, encouraging overconfidence rather than preserving uncertainty for unfamiliar inputs. We instead employ Wasserstein-based objectives, which respect the geometry of the probability simplex, and study the influence of the Wasserstein order on segmentation accuracy and OOD detection within a unified evidential framework. We evaluate this framework on a convolutional (DeepLabV3+) and a transformer-based (SegFormer) architecture on the SegmentMeIfYouCan benchmark, including LostAndFound, RoadObstacle21, RoadAnomaly21, and Fishyscapes. Our results show the optimal Wasserstein order is architecture-dependent: second-order objectives dominate on the convolutional backbone, third-order objectives on the transformer backbone, and our framework surpasses comparable baselines on most metrics, with a single deterministic forward pass.
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URL
https://arxiv.org/abs/2610.10116
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Bringing BNNs to Fast Event Processing
2026-10-07 11:33:25Paul Longour, Julien Moreau, Franck DavoineAbstract
Binary Neural Networks (BNNs) enable efficient deep learning deployment on resource constrained devices with weights and activations compressed to one bit, substantially reducing model size and inference cost. Event cameras offer complementary advantages, including low latency, high dynamic range, and low power consumption, by capturing asynchronous streams of events rather than dense image frames. Despite their shared emphasis on efficiency, the combination of these technologies remains largely unexplored. This work aims at adapting and evaluating modern deep BNN architectures on event data. We also show that cross-modal pretraining from RGB data can improve the classification accuracy of BNNs on neuromorphic datasets. We introduce the Polar-wise Binary Event Volume (PBEV), a binary representation that enables event-camera data to be processed directly by BNNs and represents a step toward fully binarized event-based vision systems. Best evaluated BNN on N-Caltech101 classification benchmarks shows 90.58% accuracy with 7.5x less operations than their full-precision counterparts.
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https://arxiv.org/abs/2610.09873
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MRCert: Towards Post-deployment Patch Robustness Certification for Adversarially Patched Samples via Type-specific Masking
2026-10-07 07:27:16Qilin Zhou, Zhengyuan Wei, Haipeng Wang, Zhuo Wang, Shuo Liu, W. K. ChanAbstract
In post-deployment time, inputs to deep learning models may or may not be adversarially patched. Patch robustness certification on such inputs within a patch bound can verify their label benignity and should retain high prediction accuracy. However, existing smoothing-based and masking-based recovery defenders cannot achieve both simultaneously: they degrade the prediction accuracy much and cannot verify the benignity of the returned label of an adversarially patched input, respectively. We propose MRCert, the first masking-based certified recovery defender that shows the feasibility of achieving both. Unlike all existing works to apply a common condition across both types of input (benign and adversarially patched samples) for certification, MRCert infers type-specific necessary properties of deep learning models for both types in post-deployment time and formally relates them to verify the label benignity through a novel type-oriented design of label recovery and certification function pair. Without incurring the degradation in clean accuracy caused by smoothing, experimental results confirm that MRCert achieves 35.1\% adversarial certified accuracy on ImageNet at patch size 16 pixels, whereas the SOTA PatchCURE fails completely.
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https://arxiv.org/abs/2610.10617
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Anaximander: Interactively Running Geospatial Deep Learning Models on Any Compute Backend
2026-10-06 20:31:38Satej S. Soman, Akram Zaytar, Girmaw A. Tadesse, Gilles Q. Hacheme, Muhammad S. Danish, Inbal Becker-Reshef, Rahul Dodhia, Juan Lavista FerresAbstract
Applying deep learning models to satellite imagery from within geographic information systems (GIS) remains high-friction for remote sensing practitioners. Models arrive in incompatible formats and target different compute environments, from local workstations to serverless cloud services. As a result, every evaluation demands custom deployment, tiling, and georeferencing code before a single prediction reaches the analyst's map. This friction discourages systematic comparison in a domain where model choice directly affects operational outcomes such as field delineation, crop monitoring, and disaster response. We present Anaximander, an open-source system that unifies model source and compute location choice behind one interactive interface. The system's backend is an inference server that loads models from multiple commonly-used sources and serves them on any accessible compute backend. The server provides session management and model caching, and streams results back per tile. The backend is paired with a QGIS plugin that drives tiling, result reassembly, georeferencing, and real-time per-tile status visualization. An additional user-interface path injects layer legends as prompts into vision-language models. We demonstrate the system in a code-free side-by-side comparison of three heterogeneous models on an agricultural field delineation task: gpt-image-1 via a cloud API, Segment Anything Model 3 (SAM3) on a remote GPU, and DelineateAnything on a local CPU. The inference backend and protocol are open-source and available at this https URL.
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https://arxiv.org/abs/2610.09085
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Beyond Explanation: Debugging Medical Imaging Models via Concept Intervention
2026-10-06 19:31:42Samrajya Thapa, Daniel J. Quest, Timothy L. Kline, Carrie L. Langstraat, Emanuel C. Trabuco, Wei LeAbstract
Medical imaging models often operate as black boxes, limiting interpretability and systematic debugging. We introduce an easy-to-use, plug-and-play framework for concept-based interpretation and model refinement. By aligning a single-modality encoder to BioMedCLIP, we construct a Concept Bottleneck Model (CBM) that enables concept-level interventions. These interventions allow us to isolate causal versus spuriously correlated concepts, validate insights with domain experts, and generate counterfactual samples for targeted fine-tuning. We evaluate our framework on a Mayo Clinic ultrasound dataset and the CheXpert 5x200 chest X-ray dataset. Results demonstrate that concept intervention enables reliable model diagnosis while maintaining, and occasionally improving predictive performance via guided fine-tuning. Our findings highlight the practical value of this framework for controlled, interpretable refinement of clinical deep learning models.
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https://arxiv.org/abs/2610.09031
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FedDermaSeg: Federated Learning for Dermatological Image Segmentation
2026-10-06 15:49:04Anabik Pal, Ganesh Patidar, Bikash SantraAbstract
Skin cancer is a major global health concern, and early detection and accurate lesion delineation are important for effective diagnosis and treatment planning. Automated skin lesion analysis can assist dermatologists, with lesion segmentation serving as a fundamental step in computer-aided diagnostic systems. Conventional deep learning-based segmentation models typically rely on centralized training, where images and their corresponding segmentation masks are collected on a central server. Such data aggregation raises privacy concerns in medical applications and requires substantial centralized computational resources. To address these limitations, we investigate the feasibility of federated learning for privacy-preserving skin lesion segmentation. The training and validation sets of the ISIC 2018 Skin Lesion Segmentation Challenge dataset are used to simulate a distributed learning environment and develop a federated segmentation model. The resulting model is evaluated on the ISIC 2018 test set and the PH2 dataset to assess its performance and generalizability. Experimental results demonstrate that the federated model achieves performance comparable to centralized training while consistently improving upon the locally trained models. These findings demonstrate the potential of federated learning for collaborative skin lesion segmentation without requiring centralized aggregation of medical images.
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URL
https://arxiv.org/abs/2610.08574
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MedCORE: Criteria-Grounded Clinical Reasoning for Interpretable Medical Image Diagnosis
2026-10-06 15:23:01Asim Khan, Samee Ullah Khan, Dwarikanath MahapatraAbstract
Clinical diagnosis is inherently a structured reasoning process, yet existing deep learning models often bypass this structure by mapping image features directly to disease labels without explicitly interrogating the morphological and textural criteria that clinicians systematically evaluate. This limits diagnostic transparency and may compromise safe clinical deployment. We present MedCORE (Medical Criteria-Oriented Reasoning and Evidence), a structured diagnostic framework that operationalizes clinical reasoning within a vision-language architecture. For each input image, MedCORE decomposes the diagnostic process into clinically defined criteria, spatially localizes each criterion to diagnostically relevant image regions, encodes evidence through multi-scale representations that capture macro-structural and micro-textural pathological characteristics, and refines criterion representations using a Graph Attention Network that explicitly models inter-criteria dependencies. Criterion representations are further aligned with clinical text descriptors, reinforced through class-wise visual prototypes, and aggregated using uncertainty-calibrated weighting that proportionally discounts low-confidence diagnostic evidence. MedCORE is validated across three clinically heterogeneous imaging modalities, including dermoscopic lesion classification on ISIC 2018, breast ultrasound lesion characterization on BUSI, and diabetic retinopathy grading on IDRiD. Quantitatively, MedCORE achieves 89.2% accuracy, 85.7% macro-F1, and 96.4% AUC on ISIC 2018; 96.1% accuracy, 95.2% macro-F1, and 98.4% AUC on BUSI; and 84.3% accuracy, 80.2% macro-F1, and 92.8% AUC on IDRiD. These results demonstrate consistent improvements over strong CNN, transformer, biomedical vision-language, concept-based, and prototype-based baselines.
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URL
https://arxiv.org/abs/2610.08528
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Atom-JEPA: Joint-Embedding Predictive Architecture for 3D Atomistic Systems
2026-10-06 14:13:51Kasper Helverskov Petersen, Rasmus Hannibal Tirsgaard, Fran\c{c}ois R J Cornet, Mikkel Jordahn, Mikkel N. SchmidtAbstract
Large-scale self-supervised pretraining has reshaped modern machine learning, substantially advancing the ability of language and vision models to generalize across downstream tasks. While deep learning has driven considerable progress in modeling atomistic systems in recent years, self-supervised pretraining in this domain has not yet achieved comparable downstream generalization. To address this, we introduce Atom-JEPA, a self-supervised pretraining framework that learns latent representations from unlabeled 3D structures through complementary atom-level and substructure-level objectives inspired by joint-embedding predictive architectures. We pretrain Atom-JEPA on large-scale molecular and crystalline datasets and evaluate its transfer performance by fine-tuning on a diverse set of downstream property prediction tasks. Atom-JEPA achieves state-of-the-art performance on molecular ADMET and quantum-chemical property prediction tasks, and is highly competitive in predicting the physical properties of crystalline materials. These results demonstrate the potential of latent-space predictive pretraining to support broad downstream generalization from structural data alone. Code and pretrained model checkpoints are publicly available at this https URL
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URL
https://arxiv.org/abs/2610.08400
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RACE-FPP: A Robust AI-assisted Characterisation Enhancement for Fringe Projection Profilometry
2026-10-06 12:07:04Osman Ali (Manufacturing Metrology Team, University of Nottingham, Nottingham, United Kingdom), Xiangjun Kong (Manufacturing Metrology Team, University of Nottingham, Nottingham, United Kingdom), Tibebe Yalew (Manufacturing Metrology Team, University of Nottingham, Nottingham, United Kingdom), Waiel Elmadih (Taraz Metrology Ltd., Nottingham, United Kingdom), Samanta Piano (Manufacturing Metrology Team, University of Nottingham, Nottingham, United Kingdom)Abstract
Fringe Projection Profilometry (FPP) requires precise system characterisation to achieve reliable three-dimensional (3D) reconstructions; however, characterisation accuracy strongly depends on robust checkerboard feature localisation, which can deteriorate under challenging imaging conditions such as lens blur and characterisation target orientations. Existing deep learning-based corner detectors are typically assessed using detection metrics and camera reprojection error alone, without considering their wider impact on projector characterisation, camera-projector stereo characterisation consistency, or overall measurement accuracy. In this work, we introduce a complete FPP characterisation pipeline that incorporates deep learning-based corner detection into the standard camera characterisation workflow. We also characterise the projector by sampling phase values at the centres of the white squares in the characterisation target. Rather than treating corner detection as an isolated task, the proposed framework explicitly analyses how localisation errors propagate throughout the entire FPP characterisation chain. Performance is evaluated using detection metrics (e.g., precision and recall), camera and projector reprojection errors, and the camera and projector stereo characterisation. Across a mixed dataset of clean and degraded images, the camera reprojection error is reduced from 1.237 pixels to 0.259 pixels, while the projector reprojection error is reduced by roughly 50%. Dimensional evaluation of reconstructed artefacts shows improved geometric accuracy compared with those resulting from the conventional pipeline. Overall, the findings indicate increased robustness of system-level characterisation under challenging imaging conditions, thereby enabling more reliable industrial FPP measurements.
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URL
https://arxiv.org/abs/2610.08213
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Supermarket Product Detection and Recognition: Utilizing Deep Learning with Rectified Imagery
2026-10-06 10:44:33Mayank Sah, Jimson MathewAbstract
Product Identification has sprung up to become one of the most challenging problems in the automation of the retail industry. With the new industry 5.0 standards, automated inventory management, and catalog creation tasks are vitally important. Object identification models have emerged as a viable answer with their unprecedented identification and localization accuracy. However, the close-knit rack design of supermarkets generates the problem of angle variation in capturing images. The angle-variant densely packed images(a single image contains many objects) become overwhelming for these models alone. In this paper, we try to supplement object detection models with traditional Hough transform (HT) and homogeneous estimation concepts. We study the effect of rectified images using homography estimation and hough transform and their limitations on the problem of grocery identification. We make a case for creating a new dataset to test the effects of such rectification and produce analytical results on different scenarios of angle variation and object densities per image. Extensive experiments on different object detection models suggest that image rectification of angled images improves the detection accuracy of grocery products in images. The results also highlight the limitation of rectification on the angle of image capture and the object density of the image.
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https://arxiv.org/abs/2610.08126
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Label-Efficient Deep Learning for ECG Delineation: A Multi-Dataset Benchmark against Widely Used Delineation Tools
2026-10-06 07:32:30Jeonghwa Lim, Minje Park, Yeongyeon Na, Yujin Eom, Soyeon Lim, Young Ho Lee, Yu Jeong Kim, Sunghoon Joo, Ki Hong LeeAbstract
Electrocardiogram (ECG) delineation, the identification of waveform boundaries, is a foundational step that translates raw ECG signals into clinically interpretable measurements. Deep learning has advanced this task but remains dependent on costly expert annotations. Label-efficient strategies such as self-supervised pretraining and semi-supervised learning are expected to ease this burden, yet it remains unclear whether they yield reliable delineation and whether the deep models they produce outperform the delineation tools used in practice. We address this in two stages. First, comparing self-supervised objectives with supervised or semi-supervised fine-tuning across one internal and four external datasets, we find that pretraining helps but the objective matters, and that the value of semi-supervised fine-tuning depends on the pretraining objective. Second, we benchmark the selected deep learning model against widely used open-source (NeuroKit2, Prominence, ECGdeli) and commercial (CalECG) tools using three complementary metrics. The model ranks best on every metric and dataset, outperforming the strongest tool by a clear margin on the rhythm-diverse set (mIoU 71.3 vs. 54.8%; averaged point-wise sensitivity 92.6 vs. 76.4%), and degrades the least from sinus to arrhythmia. A rhythm-stratified and point-wise analysis further characterizes the distinctive behavior of each tool, yielding practical guidance for tool selection. These results provide systematic, multi-dataset evidence that self-supervised pretraining is effective for ECG delineation and enables a label-efficiently trained deep learning model to outperform widely used delineation tools by leveraging abundant unlabeled data. This supports adopting such models in diverse, real-world clinical settings.
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https://arxiv.org/abs/2610.07885
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Evidence Before Sampling: Interpretable Implicit Negative Candidate Discovery for Recommendation
2026-10-06 04:02:47Shreya Rajpal, Sonia Sharma, Swapnil Parekh, Lisa Li, Jeyendran Balakrishnan, Nagaraj Janardhana, Andrew Mattarella-MickeAbstract
Recommender systems learn from observed user-item interactions, but explicit negative feedback is often unavailable. Since deep learning models require negative signals for training, negative sampling methods typically treat selected unobserved interactions as negatives. However, a missing interaction does not explain why a user is uninterested in an item or whether there is sufficient evidence to label it negative. This is especially important in business recommendation, where negative signals should be interpretable and aligned with business objectives. We formulate implicit negative candidate discovery to identify unobserved interactions supported by observed customer behavior. We encode these patterns as symbolic rules, score them based on support, informativeness, and product relevance, and rank the retained rules by evidence. An LLM then interprets the retained rules using business objectives and domain knowledge; the interpretations are combined with the statistical evidence in the final report. We evaluate our method in an industrial B2B setting and across five public recommendation datasets. Candidate-quality evaluations in the industrial setting and three public datasets show higher precision than the evaluated baselines, while symbolic selection improves downstream test PR-AUC by 12.5% over random selection with four negatives per positive example in the industrial task. Our results show that negative candidate validity can be evaluated separately from downstream recommendation performance. This distinction enables evidence-based, business-aligned, and explainable negative selection, improving both interpretability and model training in sparse, skewed, real-world recommendation settings.
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https://arxiv.org/abs/2610.07708
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SimCortex v2: Joint Cortical Surface Reconstruction with Near-Zero Collisions and Self-Intersections
2026-10-05 20:49:00Kaveh Moradkhani, Sylvain BouixAbstract
Reconstructing cortical WM and pial surfaces from structural magnetic resonance imaging (MRI) is a prerequisite for surface-based neuroanatomical analysis, yet remains challenging because the cortex is thin and tightly folded. Reconstruction methods can produce geometric artifacts such as mesh self-intersections and collisions between cortical surfaces, and although recent deep learning methods have reduced reconstruction time from hours to minutes, these artifacts persist. We propose SimCortex v2, a deep learning framework for simultaneous reconstruction of the left and right WM and pial surfaces from T1-weighted MRI. SimCortex v2 estimates topologically correct initial surfaces from a volumetric segmentation and refines all four jointly using multi-scale stationary velocity fields predicted by a ribbon-conditioned, U-Net-like network. We evaluated SimCortex v2 on 560 cases from 14 cohorts, thirteen of them unseen during training, spanning ages 6-89, healthy and clinical populations, and scanners from three vendors. SimCortex v2 matched the surface-distance accuracy of the strongest baseline (average symmetric surface distance 0.253 mm) while showing no detected inter-surface collision in 92.14% of cases and the lowest self-intersection fraction (0.044%) among learning-based methods, whereas every baseline produced at least one collision in every case. Source code, configuration files, pretrained weights, preprocessed data, and the exact evaluation splits are publicly released.
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URL
https://arxiv.org/abs/2610.07378
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Hybrid Cross-Modal Attention Network for Early Breast Cancer Detection in Low-Resource Clinical Settings
2026-10-05 18:44:51Simon Hadush Nrea (Mekelle University, Mekelle, Ethiopia), Filimon Gidey Gebremichael (Mekelle University, Mekelle, Ethiopia), Gebrekirstos Hagos Gebrekirstos (Clinical Oncologist London School of Hygiene and Tropical Medicine London, UK), Yaecob Girmay Gezahegn (Mekelle University, Mekelle, Ethiopia)Abstract
Breast cancer is the leading cause of cancer-related mortality among women in Sub-Saharan Africa, where delayed diagnosis results from limited radiology expertise and fragmented clinical data systems. Although deep learning models have demonstrated strong performance in mammographic analysis, most rely solely on imaging data and are trained on Western populations, limiting their applicability in African healthcare settings. This paper presents a Hybrid Cross-Modal Attention Network (HCMAN) that integrates mammogram images with structured clinical data using transformer-based cross-modal attention mechanisms. The model was developed and validated using a locally collected dataset of 2,560 mammogram images from 1,024 patients across four Ethiopian referral hospitals, with biopsy-confirmed ground truth labels. The proposed framework achieves 97.8% accuracy, 97.2% sensitivity, 98.3% specificity, and an AUC of 0.987, significantly outperforming image-only baselines. The system demonstrates robustness to low-quality images typical of resource-limited settings, with only 3.2% performance degradation compared to 8.7% for image-only models. Cross-modal attention analysis reveals clinically appropriate behavior: higher reliance on clinical features for ambiguous cases such as dense breasts and young patients. The model's lightweight architecture enables deployment on standard hospital workstations (<2 seconds inference on CPU). This work advances sustainable, context-aware AI solutions for equitable breast cancer diagnostics in Africa.
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https://arxiv.org/abs/2610.07243
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Deep Learning Based Illegal Bowling Action Detection
2026-10-05 18:30:25Debopom Sutradhar, Niful Islam, Sudipto Mondal, Tasmima Hossain Jamim, Jubaer Muhammad Shufol, Swakkhar ShatabdaAbstract
Cricket, often referred to as the "gentleman's game," adheres to a strict rule set for both batsmen and bowlers, where each delivery can significantly impact the match outcome. Detecting illegal bowling actions is crucial for maintaining fair play, yet it remains challenging for umpires to monitor in real time. Existing sensor-based solutions have limitations in live match scenarios, making real-time assessment difficult. This paper proposes a computer vision-based deep learning solution to detect illegal bowling actions in live cricket matches. To develop and evaluate our approach, we compiled a dataset of 62 videos featuring 11 male bowlers, capturing both legal and illegal bowling actions from multiple angles-front, back, and side. However, the dataset predominantly comprises right-handed bowlers with conventional actions. The proposed system identifies two key frames, the shoulder frame and the release frame from video footage of a bowler's delivery and analyzes the change in the bowling arm's angle between these frames. If the angle difference exceeds a predefined threshold (e.g., 15 degrees), the delivery is flagged as potentially illegal. We evaluated the system on a custom dataset and achieved a high true positive rate, suggesting the system's potential effectiveness in real-time match settings. However, further research is required to validate the system across diverse environmental conditions and larger datasets to ensure generalizability and robustness in various live match scenarios. To the best of our knowledge, this is the first AI-based computer vision method for detecting illegal bowling actions in cricket.
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URL
https://arxiv.org/abs/2610.07223
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A Data-Centric Review of Plant Disease Datasets: Taxonomy, Critical Analysis, Environmental Variability, and Implications for Precision Agriculture
2026-10-05 12:34:24Aamir Hilal, Shabir Ahmad Sofi, Neeraj GoelAbstract
Despite rapid advances in artificial intelligence, reliable real-world plant disease detection remains a persistent challenge. Visual and deep learning approaches have shown promising results, but their deployment under field conditions remains limited. A key bottleneck is the reliance on laboratory-generated datasets that lack environmental diversity, realistic backgrounds, and balanced class distributions, resulting in poor generalization. In contrast, datasets collected directly from agricultural environments capture natural variability and better reflect challenges faced by farmers across regions. This review presents a critical analysis of visual and deep learning approaches for plant disease detection, with emphasis on plant disease datasets. It establishes a taxonomy based on acquisition setting, accessibility, plant diversity, disease composition, class structure, and imbalance severity, and examines their implications for model generalization and real-world deployment. A comparative analysis of laboratory and real-field datasets identifies critical gaps that hinder disease detection. The review further analyzes how multi-level dataset imbalance, including intra-class, inter-crop, and cross-dataset imbalance, and limited environmental variability affect model performance and robustness, an area insufficiently examined in existing surveys. Beyond image-based approaches, it highlights the importance of integrating environmental parameters such as temperature, humidity, and leaf wetness with image data to improve prediction under dynamic field conditions. Finally, the review identifies key challenges, research gaps, and future directions concerning dataset construction, environmental variability, structural imbalance, standardization, and multimodal disease monitoring. It provides a foundation for developing next-generation multimodal frameworks for precision agriculture.
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URL
https://arxiv.org/abs/2610.07087
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Transcriptome-informed multi-modal AI for predicting neoadjuvant therapy response from breast cancer biopsies
2026-10-02 17:52:57Jungkyu Park, Dhruva Biswas, Joseph Cappadona, Cerise Tang, Ken G. Zeng, Bartosz Machura, Chuwen Liu, Paolo Tarantino, Coral Omene, Francisco J. Esteva, Rohit Bhargava, Marcin Braun, Kamila Pa\'zdzierz, Jakub Czerwi\'nski, Hanna Roma\'nska-Knight, Albert Grinshpun, Bareket Daniel, Michele Buchinger, Frederick Howard, Piotr Wysocki, Brie Chun, Freya Schnabel, Rich Caruana, Jan Witowski, Krzysztof J. GerasAbstract
Scarcity of labeled data limits development of deep learning biomarkers in oncology. We develop a two-stage AI model predicting pathological complete response (pCR) to neoadjuvant therapy in breast cancer. The first stage learns the transcriptome from histopathology using 8,742 patients across 32 cancer types, corroborated by pathologist review and spatial agreement with measured expression. This simplifies the second stage to predicting pCR from inferred expression and clinical variables. Developed using 1,080 patients (five cohorts) and evaluated in 1,412 patients (nine cohorts), the model achieves a pooled AUROC of 0.79 (95% CI, 0.73-0.85), discriminating responders within molecular subtypes. It outperforms histopathological biomarkers, remaining stable across intratumoral sampling and with minimal biopsy tissue. Ablations show transcriptome-wide inference improves discrimination over clinical variables alone or one-stage pathology models, and robustness by avoiding genomic assays' gene selection constraints. These results indicate that biologically informed compression may generalize to data-sparse applications in precision oncology.
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https://arxiv.org/abs/2610.03693
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Preserving Anatomical Continuity: Three-Stage Pipeline for Colon Segmentation in 3D Abdominal CT Scans
2026-10-02 15:41:03Deshan Kalupahana, Sonit Singh, Praveen Ravindran, Arcot SowmyaAbstract
Accurate colon segmentation from CT images is essential for colorectal disease analysis, yet deep learning based methods often produce disconnected predictions due to complex anatomy. This study introduces a three-stage, topology-preserving segmentation pipeline to address this issue. The first stage performs initial deep learning-based segmentation, followed by centreline bridging to reconnect disjoint regions and a reconstruction stage to refine continuity. Evaluations on TotalSegmentator and RAOS datasets using overlap, distance and topology-based metrics demonstrate improved structural consistency while maintaining segmentation accuracy. The proposed method enhances topological integrity, enabling more reliable colon segmentation for clinical and research applications.
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URL
https://arxiv.org/abs/2610.03467
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Rethinking Epistemic Uncertainty in Node Classification through Information Growth
2026-10-02 15:04:47Emma Meneghini, Francesco Ferrini, Bruno Lepri, Andrea Passerini, Veronica LachiAbstract
Epistemic uncertainty should decrease as additional information about the data-generating process (DGP) becomes available to the predictor. Yet, existing graph evidential deep learning (EDL) methods for node classification typically construct epistemic uncertainty from graph-specific properties and evaluate it on downstream tasks such as out-of-distribution detection, which do not test its reducibility as information about the DGP increases. To make reducibility directly testable, we introduce a statistical framework for studying epistemic uncertainty under information growth. Our framework specifies an information-growth experimental protocol and a consistency criterion for epistemic predictors, while using projective graph DGPs to ensure that growing graphs, which in general need not provide increasing information about the same DGP, constitute coherent observations of the same underlying process. We show that EDL methods do not explicitly estimate data uncertainty arising from a single finite graph observation and instead regulate epistemic uncertainty through model hyperparameters, precluding consistency, as corroborated by controlled information-growth experiments. As an alternative, we propose graph bootstrap ensembles, capturing both data and procedural uncertainty through graph resampling and randomized training. Under the same experimental protocol, these ensembles exhibit epistemic uncertainty reduction beyond standard deep ensembles. These findings support bootstrap ensembles as candidate consistent epistemic predictors under information growth.
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https://arxiv.org/abs/2610.03418
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Evolving Hybrid Quantum-Classical Architectures for Image Classification
2026-10-02 12:37:10Devroop Kar, Daniel Krutz, Travis DesellAbstract
Hybrid quantum classical neural networks integrate parameterized quantum circuits (PQCs) with established deep learning architectures, but their performance depends strongly on the choice of quantum circuit architecture, a choice that remains largely manual. Most existing approaches rely on hand-designed or fixed circuit ansätze, requiring circuit structure, gate composition, and qubit connectivity to be specified in advance with no guarantee that they suit the task. This limitation is especially acute in image classification, where quantum circuits must transform features extracted by classical networks while remaining compact enough for practical training, requirements that generic, task-agnostic ansätze are unlikely to satisfy simultaneously. We extend EXAQC, an evolutionary framework for automated quantum circuit discovery, to image classification. EXAQC evolves PQCs as intermediate processing modules while retaining classical feature-extraction and prediction layers. On MNIST, Fashion-MNIST, and CIFAR-10, EXAQC achieves 98.42%, 90.62%, and 85.47% accuracy, respectively, while using comparable gate counts to other quantum architecture-search methods. Against classical networks, evolved hybrid models maintain comparable accuracy with substantially fewer trainable parameters, reaching 85.68% on CIFAR-10 with over 25$\times$ fewer parameters than a 10-layer CNN. Encoding choice also matters: rotation-based encodings (RX, RY, U3) outperform amplitude encoding by 22-25 points on CIFAR-10. These results demonstrate that automated circuit discovery yields compact quantum modules that can replace larger classical components in vision architectures while retaining competitive accuracy.
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https://arxiv.org/abs/2610.03220
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