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Using AI-based Learning Assistants in Higher Education: A Large-Scale Descriptive Analysis
2026-07-09 17:49:14Kristina Schaaff, Quintus Stierstorfer, Valerie HeckelAbstract
In this study, we present a large-scale descriptive analysis of the use of an AI-based learning assistant (Syntea) in higher education. Based on objective log data from 77,543 students enrolled in distance studies, we examine usage patterns across gender, age group, study cluster, degree, and study mode. To date, existing research on educational chatbots has largely relied on comparatively small samples and self-reported survey data, while large-scale evidence on actual usage behavior remains limited. Our findings show that Syntea is already embedded in the study routines of many learners, but that usage differs across demographic and structural contexts. By identifying these patterns, our study provides an empirical basis for the further development of AI-based learning support and contributes a large-scale analysis of educational chatbot usage in higher education.
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https://arxiv.org/abs/2607.08748
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Do You Need a Frontier Model as a Citation Verifier? Benchmarking Rubric LLMs for Deep-Research Source Attribution
2026-07-09 17:01:40Ethan Leung, Elias Lumer, Corey Feld, Austin Huber, Vamse Kumar Subbiah, Kevin PaulAbstract
Reinforcement learning increasingly relies on an LLM judge to score each rubric criterion, and that judge acts as the reward model during training. Before such a signal can be trusted, we need to know how capable the judge must be and how biased it is. We study this calibration question for citation quality in deep-research systems, where a search-grounded LLM must support each claim it writes with a cited source. Citation quality is a structured rubric task in which each attribution-citation pair is judged along two dimensions that require an LLM, source relevance and factual support. On an adversarial long-form benchmark, we score 8 off-the-shelf LLM judges from 3 model families against gold labels over 1,248 rubric decisions, all of which were human-reviewed and 378 of which were hard cases adjudicated from judge disagreements. Cheaper judges remain competitive across both dimensions, with GPT-5-mini attaining the strongest source-relevance pass-class F1 at 0.908 ($\kappa$=0.636), while on factual support the judges are statistically indistinguishable (overlapping confidence intervals), so no single model dominates. At comparable F1, the judges still differ substantially in pass-rate drift, false positive rate, and false negative rate. Scalar F1 obscures this directional bias, yet it is exactly what a downstream reinforcement learning loop would reinforce. Calibrating the judge is therefore a prerequisite for using citation rubrics as reward signals, and our results show that this calibration does not require the most expensive available model.
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https://arxiv.org/abs/2607.08700
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The complexities of patient-centred conversational artificial intelligence
2026-07-09 15:56:55Jo\~ao Matos, Olivia Buege, Donny Cheung, Gary S. Collins, Paula Dhiman, Nan Li, Bingyu Mao, Benjamin W. Nelson, Michail Ouroutzoglou, Paul Varghese, Jonathan AmarAbstract
Consumer-facing health chatbots powered by large language models (LLMs) are increasingly used for symptom assessment. However, chatbot development and evaluation often rely on cooperative, articulate, simulated patients. We analysed 2,053 real patient-chatbot conversations and found that communication patterns and expression of emotions vary widely across users. We developed a patient simulator that separately models clinical content, emotional state, conversational strategy, and communication style. In a Turing-inspired evaluation of realism with 15 human graders, simulated conversations were nearly indistinguishable from real ones, with human graders achieving an accuracy of 55%. We used five distinct patient personae, across 1,164 clinician-graded cases, to evaluate the performance of four LLMs in urgency assessment. We found that communication style can significantly alter triage outcomes. Patient-centred conversational artificial intelligence must accommodate communication diversity: systems designed for idealised, rather than realistic, interactions risk underperforming and amplifying health disparities when deployed in the real world.
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URL
https://arxiv.org/abs/2607.08625
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Towards Precision Therapy in Hepatocellular Carcinoma: A Clinical-Reasoning LLM for Risk Stratification and Treatment Guidance
2026-07-09 15:33:08Peng Cui, Jitao Wang, Siyan Xue, Yao Huang, Haoming Xia, Dong Li, Dengxiang Liu, Weilin Wang, Liping Liu, Leida Zhang, Yunfu Cui, Tao Peng, Daolin Ji, Haitao Zhao, Wei Zhang, Xiaojuan Wang, Weijie Ma, Zongren Ding, Jinlong Li, Yuan Ding, Jiajing Zhao, Zhiyu Chen, Chengkun Yang, Ziyue Huang, Jiaqi Liu, Fusheng Liu, Yang Zhou, Xiaojuan Wang, Zhongquan Sun, Shiyun Bao, Xiaojun Wang, Ming Yang, Guangxin Li, Bin Shu, Yong Liao, Hongxuan Li, Yao Tang, Shizhong Yang, Yongyi Zeng, Yufeng Yuan, Yinpeng Dong, Jihui Hao, Jun Zhu, Jiahong DongAbstract
Hepatocellular carcinoma (HCC) is a common malignancy and a leading cause of cancer-related mortality. Current guidelines and staging systems provide coarse categories, but often miss within-stage heterogeneity and the clinical context in electronic medical records (EMRs). We present HCC-STAR (Hepatocellular Carcinoma Staging, Treatment And pRognosis), a clinically aligned large language model that reads routine EMR narratives and jointly outputs risk score-based staging, ranked guideline-consistent treatments with evidence-based rationales, and individualized survival estimates. We curated about 30,000 HCC cases from SEER and expanded them into EMR-style narrative training data using a clinician-validated, prompt-based augmentation workflow. On this corpus, we developed a knowledge-aligned reasoning framework optimized with a step-verifiable composite reward, moving beyond text-level memorization of clinical guidelines. In a multi-center cohort of 6,668 patients from 12 hospitals in China, HCC-STAR achieved state-of-the-art performance in treatment recommendation and risk stratification compared with clinical guidelines and competitive models, including GPT-5 and Gemini-2.5 Pro. Hypothetical overall-survival analysis showed a median survival of 51 months under adherence to HCC-STAR recommendations, compared with 29 and 32 months under BCLC and CNLC. In clinician-centric evaluations, blinded hepatobiliary specialists rated HCC-STAR's reasoning and evidence-based justifications as trustworthy. The model surpassed resident and attending physicians in treatment accuracy and helped physicians make more accurate decisions faster when used as an assistant. These findings support HCC-STAR as a reliable and verifiable decision-support system for risk stratification and precision therapy in HCC.
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https://arxiv.org/abs/2607.08602
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SMetric: Rethink LLM Scheduling for Serving Agents with Balanced Session-centric Scheduling
2026-07-09 14:55:02Jiahao Wang, Kaizhan Lin, Kaixi Zhang, Jinbo Han, Xingda Wei, Sijie Shen, Chenguang Fang, Wenyuan Yu, Rong Chen, Haibo ChenAbstract
LLM scheduling is critical to serving, yet it remains unclear how well existing designs fit agentic serving--with LLM requests issued by agents instead of humans. This shifts the workload in two ways: (1) agents act only on complete responses, making the cluster's tokens per second (TPS) the primary goal and relaxing--not eliminating--per-token latency requirements; and (2) requests share much of their KV\$-reuse exceeds 80% of request tokens in a production trace from BAILIAN, versus 54-62% in chat. This paper first contributes a systematic study of request scheduling for agents on two real-world traces. We find that to increase KV\$ reuse, existing schedulers overly prioritize routing requests to instances caching their KV\$, overloading a few while leaving the rest idle, capping TPS. We thus present two key insights: (1) load balance need not sacrifice all KV\$ reuse, thanks to the global-tier KV\$ store and (2) by utilizing the workload's intra-session locality, balancing a small fraction of requests--the first request in each agent session--suffices to balance the cluster without sacrificing most KV\$ reuse on local instances. SMETRIC realizes these insights with balanced session-centric scheduling: it routes each session's first request purely for load balance and its follow-up requests in a cache-aware manner, preserving load balance and local reuse while keeping demand on the global tier low. Using the session turn information as the scheduling metric is deliberate: it is derived efficiently and accurately from the user inputs alone, so the scheduler stays clean and stateless. SMETRIC improves cluster TPS by 10-16% under prefill-decode colocation with a global store and prefill TPS by 2-34% under disaggregation over state-of-the-art schedulers, also with a better per-token latency.
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https://arxiv.org/abs/2607.08565
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Cognitive-structured Multimodal Agent for Multimodal Understanding, Generation, and Editing
2026-07-09 13:55:55Feng Wang, Canmiao Fu, Zhipeng Huang, Chen Li, Jing Lyu, Ge LiAbstract
Recent unified multimodal models show a single architecture can jointly perform vision/language understanding and image generation/editing. However, they repeatedly feed all historical visual and textual inputs into a shared context window, limiting long-horizon multimodal dialogue due to visual token explosion and unreliable cross-turn referencing. We propose a Cognitive-structured Multimodal Agent that externalizes visual information into an Episodic Visual Memory and selectively reactivates relevant episodes during reasoning. The agent consists of a Perceptual Abstraction Engine for structured visual abstraction, a Cognitive Retrieval Engine for cross-turn memory retrieval, and a Multimodal Executive Controller for autonomous task inference and action planning. To address the lack of turn-level retrieval supervision in existing datasets, we develop a Unified Scenario Engine that programmatically generates structured multi-turn conversations with fine-grained retrieval annotations, enabling reinforcement learning to optimize abstraction and retrieval policies. We also construct a long-horizon visual-dialogue benchmark stratified by difficulty to evaluate episodic visual recall. Our 8B agent achieves 91.4% retrieval accuracy over 20-turn sessions, surpassing 32B baselines by +8.2% while nearly halving per-turn inference time (23.1s -> 12.7s). We further present the Cognitive-structured Multimodal Agent Harness (CMA-Harness), a tool-augmented deployment of the same cognitive structure integrating persistent multimodal memory, web access, image generation/editing/composition tools, and OpenAI-compatible serving. Structured memory and modular decision-making offer a more scalable, efficient paradigm for long-horizon multimodal agents than monolithic parameter scaling. Code: this https URL ; Project page: this https URL
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URL
https://arxiv.org/abs/2607.08497
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OmniFood-Bench: Evaluating VLMs for Nutrient Reasoning and Personalized Health Advice
2026-07-09 12:46:00Qian Jiang, Zhecheng Shi, Jingpu Yang, Zirui Song, Miao FangAbstract
The rapid integration of Large Vision-Language Models (VLMs) into critical infrastructure promises to revolutionize personalized healthcare and dietary management. However, in the domain of food systems, autonomous agents face a unique and persistent challenge: the "Systemic Information Asymmetry" between visual appearance and intrinsic nutritional composition. Existing benchmarks primarily focus on coarse-grained classification tasks, such as food category recognition, which fail to evaluate the intricate reasoning chain required for real-world dietary management -- specifically, the ability to traverse from identifying hidden ingredients to estimating physical mass, and finally synthesizing safety-critical medical advice. In this paper, we introduce OmniFood-Bench, a comprehensive benchmark constructed from the MM-Food-100K dataset. Unlike previous works, OmniFood-Bench evaluates VLMs across three progressive capabilities: Basic Perception (Ingredients & Cooking Methods), Quantitative Reasoning (Portion Size & Nutritional Profiling), and Safety-Critical Advisory (Disease-Specific Recommendations). We evaluate six state-of-the-art VLMs, including gpt-5.1, gemini-3-flash, and qwen3-vl-8B. Our extensive experiments reveal a startling "Semantic-Physical Gap": while models achieve near-human accuracy in naming dishes, they exhibit catastrophic failure in mass estimation and frequently hallucinate benign advice for high-risk diabetic profiles. This work establishes a rigorous standard for trustworthiness in autonomous agents deployed for public health. The code and datasets are available in: this https URL
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https://arxiv.org/abs/2607.08423
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DrugGen 2: A disease-aware language model for enhancing drug discovery
2026-07-09 12:29:33Ali Motahharynia, Mohammadreza Ghaffarzadeh-Esfahani, Mahsa Sheikholeslami, Navid Mazrouei, Matin Irajpour, Yousof Gheisari, Hajar SirousAbstract
Current computational approaches for drug design typically focus on generating molecules conditioned on specific targets or general molecular properties, often neglecting the influence of disease context on target behavior and therapeutic outcomes. To address this gap, we introduce DrugGen-2, a novel generative model that designs small molecules conditioned on both disease ontology and target protein sequences. DrugGen-2 was developed by fine-tuning a pre-trained GPT-2 model on a curated dataset of approved drugs linked to their diseases and targets, using a two-step strategy of supervised fine-tuning followed by reinforcement learning via group relative policy optimization (GRPO). This process was guided by reward functions optimizing for chemical validity, novelty, diversity, and high predicted binding affinity. When evaluated on five protein targets relevant to diabetic nephropathy, DrugGen-2 significantly outperformed baseline models (DrugGPT and DrugGen). It demonstrated a superior capacity to generate unique molecules, exhibited greater structural similarity to approved drugs, and achieved improved predicted binding affinities across all targets. Molecular docking analyses further supported these findings, identifying candidate ligands with strong binding potential, including compounds with predicted affinities (-9.917, -9.485, and -9.367) exceeding those of reference drugs such as enalapril for angiotensin-converting enzyme (-8.283). By integrating disease-specific context into molecular generation, DrugGen-2 advances AI-assisted drug discovery, offering a powerful tool for de novo design and drug repurposing that accounts for the complex interplay between diseases and molecular targets.
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URL
https://arxiv.org/abs/2607.08404
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Game Theory Driven Multi-Agent Framework Mitigates Language Model Hallucination
2026-07-09 12:28:39Runzhe Liu, Biquan Bie, Zihao Wang, Yuchao Ma, Yexin Liu, Xinghai Li, Harry Yang, Wenbo Yang, Jinzhe Cao, Shengyang TaoAbstract
The application of lightweight Large Language Models in rule-based scientific domains remains severely limited by their tendency to mimic linguistic patterns rather than reproduce axiomatic reasoning, causing frequent hallucinations. Here, we show that G-Frame, an adaptive multi-agent framework integrating Bayesian and team game principles, establishes an automated closed-loop for high-quality data synthesis and model training. By forcing the internalization of domain constraints through structured reasoning, we synthesized a specialized corpus of 363,045 chains-of-thought and 199,589 question-answer pairs. The resulting 7B model OmniChem achieves performance parity with GPT 4o mini on custom benchmarks and ChemBench while exhibiting a 79.46% reduction in hallucinations relative to its base architecture. We further demonstrate the advanced capabilities of OmniChem in molecular design and synthesis planning. This work establishes a scalable paradigm utilizing adaptive multi-agents to overcome inherent reasoning deficiencies, offering a feasible pathway for accelerating knowledge discovery in specialized scientific fields.
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URL
https://arxiv.org/abs/2607.08403
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Token-Flow Firewall: Semantic Runtime Auditing for Persistent AI Agents
2026-07-09 12:18:40Puji Wang, Yingchen Zhang, Ruqing Zhang, Jiafeng Guo, Xueqi ChengAbstract
Persistent AI agents extend large language models (LLMs) beyond single-turn interaction into long-lived software systems. Unlike traditional chat assistants, unsafe content in these agents can propagate through persistent state, reusable skills, and tool-mediated interactions, creating a substantially larger semantic attack surface. We observe that most security-critical interactions in such agents are transmitted through natural-language token flows, including memory updates, tool arguments, retrieved files, and inter-component communications. This observation enables a new security formulation: unsafe behavior can be intercepted as risky semantic flows before reaching privileged runtime sinks. Based on this insight, we propose TokenWall, a runtime defense framework that acts as a semantic firewall over agent token flows. TokenWall performs boundary-aware semantic auditing over these flows, constructing structured source-sink audit records, applying lightweight local inspection before execution, and selectively escalating ambiguous high-risk cases to stronger arbitration modules. Unlike prior approaches that rely on sparse auditing or remote large-model oversight, TokenWall enables full-coverage pre-execution mediation while reducing remote arbitration and latency. Experiments on CIK-Bench show that TokenWall reduces attack success rate to 12.5% while maintaining a 97.4% benign executable pass rate without human confirmation. TokenWall further introduces only 0.69 seconds of additional latency on benign cases, demonstrating that semantic runtime containment can achieve a practical security-utility trade-off for persistent AI agents.
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URL
https://arxiv.org/abs/2607.08395
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Conversational AI for Rapid Scientific Prototyping: A Case Study on ESA's ELOPE Competition
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Large language models (LLMs) are increasingly used as coding partners, yet their role in accelerating scientific discovery remains underexplored. This paper presents a case study of using ChatGPT for rapid prototyping in ESA's ELOPE (Event-based Lunar OPtical flow Egomotion estimation) competition. The competition required participants to process event camera data to estimate lunar lander trajectories. Despite joining late, we achieved second place with a score of 0.01282, highlighting the potential of human-AI collaboration in competitive scientific settings. ChatGPT contributed not only executable code but also algorithmic reasoning, data handling routines, and methodological suggestions, such as using fixed number of events instead of fixed time spans for windowing. At the same time, we observed limitations: the model often introduced unnecessary structural changes, gets confused by intermediate discussions about alternative ideas, occasionally produced critical errors and forgets important aspects in longer scientific discussions. By analyzing these strengths and shortcomings, we show how conversational AI can both accelerate development and support conceptual insight in scientific research. We argue that structured integration of LLMs into the scientific workflow can enhance rapid prototyping by proposing best practices for AI-assisted scientific work.
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URL
https://arxiv.org/abs/2601.04920
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On the Role of Conversational Timing in Synthetic Training Data for ASR
2026-07-09 11:40:33M\'at\'e Gedeon, P\'eter MihajlikAbstract
Synthetic multi-speaker conversations are widely used to train conversational automatic speech recognition (ASR) systems, but it remains unclear which timing properties make simulated data most useful. This paper studies conversational timing as a controllable training variable rather than merely as a corpus statistic to be reproduced. We parameterize pause and overlap timing distributions with an exponential-tilting family estimated from multiple conversational corpora, and then explore the resulting four-dimensional parameter space with Latin hypercube sampling and multi-objective Bayesian optimization. Each sampled timing configuration is used to generate simulated training conversations, train an ASR system, and evaluate concatenated-permutation word and character error rates (cpWER and cpCER) on a Hungarian dialogue corpus. The results show that downstream ASR behavior is explained more directly by induced timing statistics than by raw simulator coordinates or corpus proximity. In particular, higher overlap exposure is associated with lower cpWER, whereas longer and more variable gaps are associated with higher cpWER; cpCER follows the same trend, but with weaker statistical support. Bayesian optimization yields modest aggregate improvements, but its main value is analytical: it produces controlled timing interventions that reveal an overlap--gap trade-off in simulated conversational training data. These findings suggest that realistic simulation should be complemented by task-relevant diagnostics of overlap, gap, and timing-variability profiles.
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https://arxiv.org/abs/2607.08371
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MentalHospital: A Virtual Environment for Evaluating Psychiatric Clinical Encounters
2026-07-09 09:03:42Yuming Yang, Xiao Sun, Yuanwei Zou, Zhengxiao Wu, Yun Chen, Jiang Zhong, Haoyang Zeng, Jingwang Huang, Kaiwen WeiAbstract
Large language models (LLMs) have shown strong performance on isolated psychiatric tasks, including dialogue, diagnosis, and treatment planning, yet existing benchmarks rarely simulate complete psychiatric clinical encounters. We introduce $\textbf{MentalHospital}$, a virtual evaluation environment for LLM-based psychiatric clinical encounters. MentalHospital instantiates the Subjective Interviewing, Objective Examination, Diagnostic Assessment, and Treatment Planning (S.O.A.P.) workflow, using skill-augmented standardized patients constructed from 1,193 de-identified psychiatric electronic health record (EHR) cases spanning all major ICD-11 categories and 76 disorders. Each encounter is assessed through a dual-track protocol that combines objective comparison against EHR-derived references with subjective assessment of clinical process quality. To scale specialist judgment, we develop $\textbf{MentalEval}$, five domain-specific evaluators covering communication empathy, interviewing professionalism, clinical-note quality, diagnostic rigor, and treatment appropriateness, trained with rubric-grounded SFT and expert-guided DPO. Survey responses from 22 clinicians support MentalHospital's clinical fidelity (3.88/5), while MentalEval achieves strong expert alignment with an average QWK of 0.944. Benchmarking shows that even the strongest LLM trails clinicians by 37.28 percentage points in objective psychiatric competence, with mental status assessment as a key bottleneck.
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URL
https://arxiv.org/abs/2607.08257
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Compete Then Collaborate: Frontier AI Teachers Build a Verifiable Curriculum to Improve a Coding Student Beyond Imitation
2026-07-09 09:00:52Miseong Shawn KimAbstract
Large language models increasingly serve as teachers generating training data for smaller students. Prior multi-teacher knowledge distillation methods merge outputs without determining which frontier model teaches best, often relying on an LLM judge biased toward its own outputs. We introduce a compete-then-collaborate framework where four frontier AI teachers (Claude, Codex-GPT, Grok, Gemini) are ranked head-to-head by an execution-based judge (unit tests and stdin-stdout checks) with fairness controls, and then collaborate to build a verifiable curriculum for a student (Qwen2.5-Coder). We report three findings. (1) Under execution verification, all teachers solve standard problems near-perfectly after self-correction (99-100%) due to a saturation effect, but harder competition problems separate them (Gemini 77% > Claude 69% = Codex 69% > Grok 50%); however, the robust student-side results do not depend on teacher ranking. (2) Imitation (SFT) on verified solutions does not improve, and can degrade, an already-competent student at 7B and 32B (e.g., from 76.7% to 72.7% on MBPP-test, and 5.9% to 2.9% on competition problems). (3) Using the same collaborative curriculum as a reinforcement learning with verifiable rewards (RLVR) environment improves the student (from 5.9% to 8.8% peak on competition problems, a +49% relative gain), reversing SFT's direction. The value of AI-teacher collaboration lies not in pooling answers to imitate, but in jointly constructing a verifiable environment where the student learns by doing. We release a reproducible on-prem pipeline (NVIDIA GB10) with framework patches for running GRPO on a bleeding-edge stack.
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URL
https://arxiv.org/abs/2607.08255
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LEXIC: Lightweight Eye-tracking eXtension via Injected Complexity
2026-07-09 06:46:19Sumin Lee, Kyeonghun Kim, Subeen Lee, Jiwon Yang, Tien Nguyen, Ken Ying-Kai Liao, Nam-Joon KimAbstract
On the recent EyeBench benchmark, predicting reading comprehension from eye movements exposes a stark gap: text-aware models using pretrained language models reach 56--63% AUROC, while gaze-only models operate at chance. We ask how far a gaze-only model can be pushed by lightweight, language-model-free conditioning. Building on the EyeBench AhnCNN baseline, LEXIC-Base, we propose two mechanisms to inject three precomputed word-level difficulty signals, GPT-2 surprisal, word frequency, and word length, into the per-fixation input: direct concatenation, LEXIC-Concat, and a residual mechanism, LEXIC-Res, where a small head predicts typical-reader gaze response and the encoder is conditioned on the deviation. On the OneStop reading comprehension task, with K=5 seed-ensemble training across ten folds, both mechanisms produce statistically consistent AUROC gains on Unseen Text, +1.8 to +2.2 percentage points, Wilcoxon p <= 0.065. LEXIC-Concat additionally lifts Unseen Reader by +2.9 percentage points, p = 0.010. We trace an architectural boundary in LEXIC-Res on Unseen Reader, +1.8 percentage points, p = 0.19, to the prediction head being calibrated to training readers, transferring imperfectly to out-of-distribution readers.
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URL
https://arxiv.org/abs/2607.08152
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Persuasion Attacks Can Decrease Effectiveness of CoT Monitoring
2026-07-09 02:48:36Jennifer Za, Julija Bainiaksina, Nikita Ostrovsky, Tanush Chopra, Victoria KrakovnaAbstract
Chain-of-thought (CoT) monitoring is a promising safety mechanism for AI agents, based on the premise that visible reasoning traces can surface misaligned or deceptive behavior. While effective in standard scenarios, recent work highlights that LLMs remain vulnerable to persuasion-based jailbreaks, where natural-language arguments override model constraints. We stress-test whether this vulnerability extends to monitoring LLMs: can an adversarial agent persuade its CoT monitor to approve proposed actions that violate the monitor's policy? We design an evaluation framework with 40 tasks and analyze thousands of agent-monitor interactions, where agents are instructed to argue for policy-violating proposals. We find that in such adversarial settings, monitor access to the agent's CoT reasoning increases rather than decreases approval of harmful actions on average by 9.5%, as the scratchpad provides an additional persuasion channel. To address this, we introduce a fact-checking monitoring framework. We find that a fact-checker and monitor pairing from different model families, for example a Claude 3.7 Sonnet monitor paired with a GPT-4.1 fact-checker, reduces approval of policy-violating actions by up to 45%, compared to only 6%, when using the same model for both fact-checking and monitoring roles. Our results demonstrate that CoT monitoring alone may be insufficient against adversarial persuasion, and that model-diverse fact-checking provides a robust mitigation.
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URL
https://arxiv.org/abs/2607.08066
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Aleena: Alignment Agent for Research Software Engineering Collaborations
2026-07-09 01:36:18Kshitij Dani, Cordero Core, Landung Setiawan, Carlos Garcia Jurado Suarez, Anshul Tambay, Vani Mandava, Anant MittalAbstract
Research software collaborations span meetings, informal chats, pull requests, and GitHub issues. A decision surfaced in a Slack thread, refined in a meeting, and implemented in a pull request can lose its original rationale across these artifacts, leaving domain researchers and research software engineers with divergent mental models of project intent, ownership, and scientific assumptions. We argue that alignment in research software engineering is a continuous lifecycle problem, and that agentic AI can support stakeholder alignment and project-state tracking without replacing human decision-making. We present Aleena, an open-source lifecycle alignment agent that uses GitHub as a shared collaboration surface, transforming multi-modal stakeholder interactions into structured project records that surface risks, track open questions, and preserve decision continuity. Grounded in university-based research software engineering center experiences, this paper presents the motivating problem, system design, prototype, and illustrative lifecycle scenarios for Aleena.
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URL
https://arxiv.org/abs/2607.08043
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A safety-oriented hypothetico-deductive framework for AI-assisted differential diagnosis
2026-07-09 01:30:24Fan Ma, Mauro Giuffr\`e, Donald Wright, Kent McCann, Mark Iscoe, Lingfei Qian, Mingyang Jiang, Chi Wing Ng, Na Hong, Huan He, Cathy Shyr, Qingyu Chen, Lee Schwamm, Lucila Ohno-Machado, Hua XuAbstract
Diagnostic error is a major threat to patient safety, yet current large language model (LLM) systems often treat diagnosis as a one-shot prediction task, lacking safeguards against missed high-risk alternatives or rigorous verification of their reasoning. Here, we present AegisDx, a safety-oriented framework for hypothetico-deductive clinical reasoning. AegisDx coordinates specialized LLM components through role-specific contracts, structured intermediate outputs, evidence-retrieval interfaces, and verification gates to generate broad differential diagnoses, enforce explicit screening for dangerous "must-not-miss" conditions, verify reasoning against grounded medical evidence, and structure actionable next steps. We evaluated AegisDx across three layers. On literature-derived case reports from NEJM and JAMA, with GPT-oss-120B as the shared backbone, Top-3 diagnostic accuracy was 59.9% versus 52.1% for the standalone LLM on JAMA cases and 62.7% versus 51.4% on NEJM cases. On cases from Annals of Emergency Medicine, Top-3 accuracy was 85.7% versus 68.6%; against physician-consensus must-not-miss diagnosis sets, AegisDx captured at least one such condition among its top three diagnoses in 78.0% of cases versus 52.0%. In a blinded physician evaluation of 43 real-world emergency department notes from the Yale New Haven Health System compared against GPT-5, AegisDx improved the physician-rated composite safety score from 4.31 to 4.55 on a 5-point scale (adjusted p = 2.1x10^-4), with qualitative gains in must-not-miss identification and reasoning safety. Our findings suggest that engineering diagnostic AI as a safety-oriented reasoning framework, rather than optimizing raw predictive accuracy alone, can provide a safer, more transparent, and clinically meaningful layer of bedside decision support for acute care workflows.
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URL
https://arxiv.org/abs/2607.08038
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From Triggers to Emotions: A CPM-Grounded Appraisal Multi-Agent for Dynamic Emotional Evolution in Persona-Based Dialogue
2026-07-08 18:06:03Jingyao Cai, Shuaijun Liu, Abdul Rehman, Yutong Guo, Qin Tian, Thomas Dolby, Sue Green, Chantel Cox, Xiaosong YangAbstract
Large Language Models (LLMs) have substantially advanced persona-based dialogue agents for emotion-sensitive role simulation in healthcare, education, counseling, customer service, and interactive storytelling. However, two related lines of work leave a key gap. Persona-based dialogue systems often encode emotions as static traits or surface-level stylistic cues, and affective dialogue research has largely focused on empathetic response generation toward users rather than modeling the agent persona's own evolving emotional state. As a result, trigger-driven emotional evolution within a character remains underexplored. To address this limitation, we draw inspiration from the Component Process Model (CPM), a psychological theory that views emotion as a dynamic process shaped by the appraisal of external events. We propose CPM-MultiAgent, a CPM-grounded emotion evolution multi-agent framework for supporting emotional changes in persona-based dialogue. Instead of treating a character's emotion as a fixed attribute, CPM-MultiAgent represents it as a latent state that is continuously reshaped by dialogue triggers. Through affective trigger extraction, CPM-based collaborative appraisal, and emotion state updating, the framework enables more emotionally consistent role simulation in multi-turn this http URL with baseline comparisons, ablation studies, human evaluation, and case analyses demonstrate that CPM-MultiAgent effectively models dynamic emotional evolution in emotionally sensitive role-simulation settings.
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URL
https://arxiv.org/abs/2607.07824
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Co-LMLM: Continuous-Query Limited Memory Language Models
2026-07-08 17:59:45Yair Feldman, Linxi Zhao, Nathan Godey, Dongyoung Go, Yilun Hua, Kilian Q. Weinberger, Jennifer J. Sun, Yoav ArtziAbstract
Limited memory language models (LMLMs) externalize factual knowledge during pretraining to a knowledge base (KB), rather than memorizing it in their weights. During generation, the model then fetches knowledge from the KB as needed. This recently introduced paradigm provides multiple advantages, including knowledge control capabilities that remain beyond conventional LLMs. We propose continuous-query LMLM (CO-LMLM), where the KB pairs continuous keys with textual knowledge values, a significant departure from prior reliance on relational KB and queries. CO-LMLM generates flexible vector queries at minimal cost, while still integrating human-readable and attributable retrieved knowledge into its generation. We pair this design with an annotation pipeline that tags free-form factual spans in arbitrary text, removing prior work's restriction to Wikipedia. Across pretraining on Wikipedia and FineWeb-Edu and at multiple model scales, CO-LMLM outperforms prior LMLMs and vanilla LLMs in both perplexity and factual precision. At 360M scale, this includes lower perplexity than models pretrained on 40x more data, and SimpleQA-verified performance that is in line with gpt-4o-mini and higher than Claude Sonnet 4.5.
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URL
https://arxiv.org/abs/2607.07707
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