This paper studies the problem of learning a joint distribution from marginal observations, which is inherently ill-posed due to the ambiguity of feasible couplings. We propose LUD-MSR, a latent-variable probabilistic framework that models the joint distribution via auxiliary representations and optimizes evidence lower bounds using only marginal data. Under mild assumptions, we establish an upper bound on the distribution approximation error. This analysis reveals a trade-off in representation learning between domain consistency and information preservation. To address this trade-off, we introduce a Multi-Scale image Representation (MSR) mapping that exploits structural similarity at coarse scales while suppressing domain-specific variations. We show that MSR achieves a more favorable balance of this trade-off compared to existing approaches. Experiments on real-world denoising benchmarks, including cryo-electron microscopy (cryo-EM), demonstrate the effectiveness of the proposed framework.
https://arxiv.org/abs/2607.08198
Existing NAS benchmarks (e.g., NAS-Bench, NATS-Bench) cover only narrow, task-specific regions of the architectural design space and lack cross-domain or deployment-aware evaluation. LEMUR 2 introduces a large-scale, extensible framework unifying generative, evaluative, and deployment pipelines to unlock neural-network diversity. It comprises over 14,000 distinct architectures and more than 750,000 structured training records documenting model performance, hyperparameters, and task outcomes. These models were produced through AST-based code mutation, genetic and reinforcement-learning evolution, generation of fractal architectures, and synthesis guided by a Large Language Model (LLM). This includes deep models generated with the retrieval-augmented system NN-RAG, which derived and used architectural motifs from over 900 PyTorch modules extracted from public repositories. LEMUR 2 further employs NN-VR and NN-Lite pipelines for automated deployment and latency benchmarking on heterogeneous mobile and Unity-based VR platforms, providing real-device performance metadata. It spans multimodal tasks, image captioning, text-to-image synthesis, and language modeling, supporting cross-domain analysis of architectural transferability. By linking diverse architectures, tasks, and deployment data, LEMUR 2 provides the data foundation for LLM fine-tuning and coupling diverse architectural origins with large-scale, cross-platform empirical validation. This dataset defines a new basis for reproducible and data-driven AI design, advancing the emerging paradigm of LLM-driven AutoML and architectural generalization across modalities and hardware.
https://arxiv.org/abs/2607.06839
Non-invasive prediction of Gleason Grade Group (GGG) in prostate cancer using multiparametric MRI (mpMRI) is clinically vital for reducing unnecessary biopsies. Existing GGG prediction methods face two major limitations. First, they often overlook non-image information critical for GGG prediction, including age, prostate-specific antigen (PSA), and expert priors embedded in radiology reports. Second, they tend to oversimplify GGG as flat categorical labels, failing to account for its intrinsic hierarchy of primary and secondary Gleason patterns. To this end, we propose a novel Knowledge-Driven Ordinal-Aware Learning (KOAL) framework with three synergistic modules. Specifically, the Clinical-Context Modulation (CCM) module uses clinical variables (e.g., age and PSA) to dynamically modulate discriminative image representations. The Knowledge-Guided Prototype Alignment (KGPA) module leverages an LLM to extract group-specific expert knowledge from training radiology reports and clinical guidelines, producing offline semantic anchors describing grade-specific radiological findings without requiring patient-specific reports at inference. Through prototype contrastive alignment, patient-specific mpMRI representations are matched with these anchors to promote pathology-aligned representation learning. The Hierarchical Ordinal-aware Constraints (HOC) module decouples primary and secondary Gleason pattern prediction and maps their probabilistic outputs to GGG via a Differentiable Bio-logic Mapping Layer (DBML), ensuring pathological grading consistency. Experiments on public PI-CAI and in-house datasets demonstrate that KOAL outperforms state-of-the-art methods. Code is available at: this https URL.
https://arxiv.org/abs/2607.06019
Gaussian-based image representations effectively model image content using compact parametric primitives while preserving high visual fidelity, yet storing a large number of floating-point parameters per primitive degrades rate-distortion efficiency at higher fidelity targets. To improve the rate-distortion performance in Gaussian representation, we present our Cluster-Guided Vector Quantization (CGVQ), a Gaussian primitive based image compression method. Our key idea is to partition Gaussian parameters further into homogeneous groups prior to quantization, enabling higher compression efficiency and accurate parameter reconstruction. In practice, our extensive experiments show that CGVQ decreases the bpp by 20% with respect to our baseline, while maintaining on-par visual quality
https://arxiv.org/abs/2607.05667
Zero-shot composed image retrieval (ZS-CIR) aims to retrieve a target image from a multimodal query consisting of a reference image and an edit text describing the desired modification. Recent ZS-CIR studies have relied on projection-based methods that map a reference image into pseudo-word tokens in the text embedding space. However, such methods require additional projection and re-encoding steps, increasing training complexity, reducing efficiency, and introducing a discrepancy between training and inference. In this paper, we propose DiCE-CIR, a direct composition learning method that predicts composed query representations by directly composing a reference image and an edit text. To enable scalable training without manually annotated triplets, we automatically construct compositional training samples from large-scale image-caption pairs using a large language model. Based on these samples, we train a lightweight composition module with objectives that promote alignment with the target, edit-consistent semantic transformation, and retrieval discriminability. We conduct extensive experiments on ZS-CIR benchmarks and show that DiCE-CIR achieves state-of-the-art performance on CIRCO and competitive performance on CIRR while maintaining high computational efficiency.
https://arxiv.org/abs/2607.04665
Unified Multimodal Models (UMMs) integrate image understanding and generation within a single architecture, yet how the two tasks interact remains understudied. We investigate $\boldsymbol{\mathsf{transferability}}$ in UMMs: whether training a capability on one task improves the same capability on the other without explicit supervision. Through controlled experiments, we empirically find that transferability depends on architecture-models with fully shared transformer backbone and a unified visual encoder exhibit consistent cross-task transfer, while loosely coupled designs show little or none. Leveraging this transferability, we propose a practical training strategy. The most straightforward way to improve a target generative capability (e.g., counting) is to fine-tune generation directly, but this can degrade visual quality due to distribution shift. Instead, we train the corresponding understanding task and let it transfer into generation, which improves capability-specific generative performance while minimizing distribution shift. We validate this across three capabilities-counting, spatial relation, and text recognition/generation-showing that cross-task transferability can be systematically exploited in UMMs.
https://arxiv.org/abs/2607.04423
While Large Vision-Language Models (VLMs) demonstrate remarkable generic capabilities, their clinical reasoning in specialized domains like ocular surface diseases (OSDs) is severely hindered by a paucity of high-fidelity, multimodal instruction-tuning data. To dismantle this data bottleneck, we introduce IRIS, an Intelligent Recognition and Interaction System tailored for fine-grained OSD understanding via external eye photography. First, we curate IRIS-120K, the largest and most comprehensive OSD visual question-answering (VQA) dataset to date. Crucially, to overcome the semantic shallowness of conventional image-caption pairs, we propose a synergistic data generation paradigm to explicitly inject clinical priors. Our data engine operates via a dual-branch framework: 1) a Topic Finding Tree (TFT) that hierarchically anchors visual features to precise anatomical and pathological concepts, enforcing rigorous medical deduction logic; and 2) a Scene-driven strategy that synthesizes role-adaptive clinical dialogues to ensure pragmatic generalization. By explicitly aligning a compact 4B-parameter VLM on this structurally enriched corpus, IRIS achieves state-of-the-art performance, comprehensively outperforming both generalist and specialized medical VLMs with up to 34B parameters. Our findings underscore that structured knowledge injection profoundly prevails over sheer parameter scaling, unlocking the potential for resource-efficient, expert-level AI deployment on mobile edge devices for scalable OSD screening. Code, datasets, and model weights will be publicly released by this repo.
https://arxiv.org/abs/2607.04344
Large generative models across text-to-text, text-to-image, and image-to-text modalities have been shown to pose significant privacy risks. One fundamental threat is membership inference attacks (MIA), which aim to determine whether a given data point was used in a model's training set. Although prior work has investigated MIAs against these three classes of generative models, existing approaches treat them in isolation and are not cross-applicable, thereby limiting their real-world utility. To address this limitation, we present the first comprehensive study of a unified membership inference framework that applies across text-to-text, text-to-image, and image-to-text modalities. Our approach is grounded in a key modality-agnostic observation: the output distribution of a generative model can approximate its training data distribution. Leveraging this property, we model the distributions of model-generated outputs and auxiliary non-member samples in a shared embedding space, and perform membership inference via likelihood ratio testing. We conduct extensive experiments in a strict black-box setting under both partial-knowledge and zero-knowledge threat models, and evaluate membership inference against both fine-tuning and pre-training data. Experimental results demonstrate our approach's superior performance in comparison to existing state-of-the-art methods, which are typically optimized for a single model class.
https://arxiv.org/abs/2607.04339
Large Vision-Language Models (LVLMs) have achieved remarkable progress in visual understanding tasks such as image captioning and visual question answering. However, they remain susceptible to hallucinations, generating content that is inconsistent with the actual visual input. Existing methods primarily intervene at the decoding stage, while overlooking a critical source of hallucinations: irrelevant or noisy visual tokens that mislead the decoding process. To address this issue, we propose SeeMe, a training-free framework that introduces the concept of feature engineering from traditional machine learning into LVLMs. SeeMe restructures visual tokens through a three-stage token engineering process to suppress hallucination sources while preserving informative visual evidence. Experiments on MME, POPE, and AMBER benchmarks across four LVLMs demonstrate that SeeMe consistently reduces hallucinations and improves output consistency, providing a novel perspective for mitigating hallucinations in LVLMs.
https://arxiv.org/abs/2607.04163
Chronic wound assessment remains a clinically challenging task that requires accurate interpretation of wound morphology, tissue composition, vascular characteristics, and infection risk. Recent advances in Vision-Language Models (VLMs) have introduced the possibility of automated multimodal wound analysis through image understanding combined with clinical reasoning. This study evaluates the performance of several general-purpose and medically specialized open-source and proprietary VLMs for clinical wound assessment using an expanded, curated dataset of 20 clinically diverse wounds spanning vascular, surgical, ischemic, venous, lymphedema, and amputation-related etiologies. Six VLMs were evaluated using a structured twelve-question clinical framework covering wound classification, infection risk, vascular intervention recommendations, debridement urgency, wound therapy selection, and advanced management planning. Across 20 wound cases and 240 clinician-graded wound-analysis decisions, ChatGPT achieved the highest overall performance with 174/240 correct responses (72.50%), followed by Claude with 149/240 (62.08%). Among the open-source and medically specialized models, HuluMed achieved the strongest performance with 96/240 correct responses (40.00%), followed by Gemma 3 (81/240, 33.75%), MedGemma 4B (62/240, 25.83%), and MedGemma 27B (42/240, 17.50%). The findings suggest that frontier general-purpose multimodal systems currently demonstrate substantially stronger wound-analysis performance than medically specialized alternatives, highlighting the continued importance of broad multimodal reasoning capabilities alongside domain-specific medical knowledge. Although current VLMs demonstrate promising potential for clinical decision support, substantial limitations remain in advanced wound-management reasoning, procedural planning, and autonomous clinical reliability.
https://arxiv.org/abs/2606.20723
Materials phase diagrams are a core knowledge representation in materials science, encoding temperature,composition, phase stability, and phase transformation pathways, with their full understanding requiring thermodynamic mechanism analysis and scientific reasoning. Although VLMs have shown promise in scientific image understanding, their systematic evaluation on such logically complex images demanding deep mechanistic interpretation remains limited, and phase diagrams provide a challenging testbed for this purpose. We introduce MatPhaseBench, a high-quality, high-reliability benchmark for complex scientific image understanding, focused on materials phase diagrams. MatPhaseBench is constructed from 3681 papers in classical materials science journals, from which 200 high-quality diagram-text pairs were selected, covering 189 material systems and 70 elements. The benchmark has three key features: (1)targeting complex scientific image understanding-it moves beyond simple objective tests to open-ended tasks requiring deep comprehension; (2)comprehensive image-text alignment-semantic information associated with images is fully preserved during literature mining and matching; (3) high-quality human-supervised text acquisition-all descriptions undergo strict manual validation. Experimental results show that current VLMs remain substantially behind expert-level understanding: they are largely limited to surface visual perception, lack deep reasoning grounded in thermodynamic mechanisms, have limited domain awareness and expert analytical experience, and perform poorly in distinguishing fine-grained differences in composite or multi-diagram settings. Overall, MatPhaseBench constitutes a challenging research-grade benchmark, providing a foundational platform for complex scientific image understanding, phase diagram analysis, and trustworthy multi-modal AI in science.
https://arxiv.org/abs/2607.02934
Glaucoma is a progressive eye disease that can lead to irreversible vision loss if not detected at an early stage. Conventional diagnostic procedures are often time-consuming and rely heavily on expert interpretation, limiting their scalability for large-scale screening. In this study, glaucoma detection is investigated under two evaluation settings: sample-wise, where individual samples are analyzed independently, and patient-wise, where data from each patient are aggregated for final prediction. An automated multimodal framework is proposed that integrates fundus images with clinical data. Under the sample-wise setting, detection is performed using fundus images and clinical features individually, as well as through their multimodal combination. Under the patient-wise setting, predictions are obtained by aggregating multiple fundus image representations with corresponding clinical information for each patient. Deep visual features are extracted using a Vision Transformer (ViT) architecture and classified using classical machine-learning models, with a stacking-based ensemble of the three best-performing classifiers employed to optimize performance. Experiments conducted on the publicly available PAPILA dataset demonstrate strong diagnostic performance, achieving 97.47% accuracy and a 97.50% F1-score for sample-wise multimodal classification, and 98.97% accuracy and F1-score for subject-wise detection. The proposed framework is further deployed as an end-to-end web-based platform to support automated glaucoma screening and clinical decision support.
https://arxiv.org/abs/2607.02692
Using molecular large language models (LLMs) as a unified framework for understanding molecular structures and functions is emerging as a new trend in tasks such as molecular design and drug discovery. However, these models struggle to fully capture the visual representation of molecular structures, limiting their potential. While existing molecular vision-language models (VLMs) show promise, they still face challenges in structural alignment and lack the necessary topological modeling for accurate molecular understanding. To address this, we propose MolSight, a graph-aware vision-language model framework designed to enhance the understanding of molecular images by VLMs. MolSight integrates a Molecular Topology Module to inject chemical-bond adjacency information into vision tokens, and a Molecular Grounding Module to align visual features with chemical symbolic semantics. Our experiments demonstrate that MolSight significantly outperforms existing VLMs, molecular LLMs, and specialized tools across multiple chemical visual understanding tasks, achieving a new level of molecular image reasoning.
https://arxiv.org/abs/2607.01982
High-resolution (HR) image perception remains a key challenge in multimodal large language models (MLLMs), as fine-grained details are often lost when the image is processed as a whole. Existing methods either require training to teach models where to look or heuristically divide the image into fixed regions, both of which struggle to generalize in complex HR scenes. In this work, we propose Hierarchical Entity Exploration (HEE), a training-free and model-agnostic framework that transforms static image understanding into dynamic, query-guided entity exploration. HEE first evaluates each region using a dual scoring mechanism to determine whether it already contains sufficient evidence to answer the question. If not, it applies object detection within the most promising region to extract fine-grained entities, clusters them into coherent subregions, and organizes them into a multi-level semantic hierarchy for deeper exploration. When deeper regions still fail to yield confident answers, a confidence-guided backtracking mechanism revisits alternative paths to ensure adaptive perception. Extensive results show that HEE outperforms training-free methods like ZoomEye and RAP in both accuracy and efficiency on two complex HR benchmarks (Visual Probe and HR-Bench), across different MLLMs such as Qwen2.5-VL and LLaVA-OneVision. Moreover, HEE demonstrates generalization on the MME-RealWorld benchmark.
https://arxiv.org/abs/2607.00816
Although Large Language Models (LLMs) excel in many tasks, their assessment in Portuguese has received less attention, particularly for open-ended, discursive tasks that demand deeper reasoning and generation capabilities. While the original BLUEX benchmark addressed the scarcity of Portuguese evaluation datasets through multiple-choice questions from Brazilian university entrance exams, it did not cover the more challenging second-phase examinations, which require free-form written responses. In this work, we introduce BLUEX v2, a benchmark derived from the second-phase entrance exams of Brazil's two leading universities: UNICAMP (Comvest) and USP (Fuvest), spanning exam years 2022--2025. Our dataset comprises 395 questions unfolding into 919 graded subquestions, with 55.7% of questions containing associated images (represented as context-aware captions during inference to enable evaluation across both vision-capable and text-only models). Each question is annotated with subject area, official reference answers, LLM-generated rubric criteria, and six cognitive capability tags. We evaluate 21 state-of-the-art LLMs using an LLM-as-a-judge protocol. Results reveal a 4.92-point performance spread across models (4.18-9.10 on a 0-10 scale), with Mathematical Reasoning and Image Understanding emerging as the hardest capability dimensions. The evaluation code, model outputs, and dataset are publicly available at this https URL and on Hugging Face at this https URL.
https://arxiv.org/abs/2606.22723
Artificial intelligence is transforming our capability to solve biological challenges. In dimensionality bottleneck regimes exacerbated by high-dimensional biological data, Neural networks force distinct concepts into the lower dimensions known as superposition. Although this superposition is widely known to hinder interpretability, its impact on corrupting the geometry of latent spaces remains critically overlooked. Here, we utilized sparse autoencoders (SAEs) trained on over 100,000 multiplexed images of patient-derived Parkinson's disease and healthy neurons to resolve superposition. This approach bypasses the mathematical non-uniqueness of feature attribution by shifting to interpretable latent representation analysis. We theoretically and empirically demonstrate that superposition contaminates representational metric spaces, and thereby SAEs successfully recover geometric fidelity. By treating these geometrically purified representations as single-cell state vectors, we adapted single-cell RNA sequencing (scRNA-seq) data analysis methodologies directly to the image domain. Finally, we introduce GW-map, utilizing Gromov-Wasserstein optimal transport to align these image representations with authentic scRNA-seq data \emph{de novo}. This coupling reconstructs hierarchical neuronal pathology pathways such as Calcium-AIS scaffold, without reference spatial transcriptomics, establishing a scalable foundation for spatial biology. Code is available at this https URL
https://arxiv.org/abs/2606.31394
Existing robot policies based on learned visual embeddings lack explicit structure and are sensitive to visual distractions. Thus, the representations that drive their behaviour are often opaque, making their decision-making process difficult to interpret. To address this, we introduce Structured Image Representations (SIR), a method that leverages Scene Graphs (SGs) as an intermediate representation for robot policy learning. Our approach first constructs a fully connected graph, using image-derived features as initial node representations. Then, a module learns to sparsify this graph end-to-end, creating a task-relevant sub-graph that is passed to the action generation model. This process makes our model intrinsically explainable. Evaluations on RoboCasa show that our sparse graph policies outperform image-based baselines on average with 19.5% vs 14.81% success rate. Most importantly, we show that the learned sparse graphs are a powerful tool for model analysis. By analysing when the model's sub-graph deviates from human expectation, such as by including distractor nodes or omitting key objects, we successfully uncover dataset biases, including spurious correlations and positional biases. this https URL
https://arxiv.org/abs/2606.30101
Building performant Vision-Language Models (VLMs) requires carefully curating large-scale training datasets, yet the community lacks systematic benchmarks for evaluating such curation strategies. We introduce DataComp for VLMs (DCVLM), a benchmark for controlled data-centric experiments to improve VLM training. As part of DCVLM, we collect 160 datasets spanning four data types -- image-caption pairs, multimodal interleaved documents, text-only, and instruction-tuning data -- into a corpus of 6T multimodal tokens. DCVLM allows participants to test curation strategies (filtering, mixing, formatting, sampling) across 1B-8B models and 6.25B-200B token budgets. Models are then evaluated on a carefully selected suite of up to 52 downstream benchmarks across 9 domains. We conduct extensive experiments on DCVLM and find that data mixing, not filtering, is key to a high-quality training dataset: instruction-heavy mixtures scale better than caption-heavy ones, with gains widening at larger scales. The resulting dataset, DCVLM-Baseline, enables training an 8B VLM to 63.6% accuracy on our 33-task core suite with 200B training tokens. Compared to FineVision, the state-of-the-art open VLM training dataset, this represents an improvement of +5.4pp. DCVLM and all accompanying artifacts will be made publicly available at this https URL.
https://arxiv.org/abs/2606.28551
Large vision-language models (LVLMs) are increasingly used for clinical image understanding, yet they remain vulnerable to \emph{hallucinations}--producing textual findings or attributes not supported by the image. We present a vision-traceable hallucination detection framework that audits arbitrary LVLM responses via visual evidence grounding, requiring neither modification nor internal access to the hidden states of LVLMs. Given an LVLM response, we extract visually verifiable entities and use a medical-domain-adapted Qwen-VL grounding verifier to localize each entity on the input image. To enhance the robustness of our detection method, we introduce a counterfactual entity perturbation method and estimate visual evidence uncertainty by contrasting factual and counterfactual grounding results. Specifically, we compute an entity-level uncertainty score from the positive confidence, counterfactual confidence, and their grounding overlap for binary hallucination decision-making. Experiments on multiple medical imaging modalities and LVLM backbones demonstrate that our method consistently improves hallucination detection performance over recent baselines, while providing interpretable localization evidence and strong cross-model transferability. Code and dataset are available at this https URL.
https://arxiv.org/abs/2606.28520
Knowledge-based Visual Question Answering (KB-VQA) requires models to combine image understanding with external knowledge. Most prior methods use a fixed retrieve-then-generate pipeline with a pre-selected retriever and a static top-k setting, which is not adaptive during reasoning. We propose ProMSA, a progressive multimodal search agent for KB-VQA. Given an image-question pair, the agent iteratively chooses image search, text search, or stop, under explicit tool-call budgets and with deduplication to avoid redundant retrieval. For training, we first use rejection-sampling SFT to learn valid tool-use formats, then optimize the agent with TN-GSPO, a sequence-level RL objective that normalizes updates by both generation length and tool-interaction depth. Experiments on E-VQA and InfoSeek show consistent gains over strong RAG and agent baselines, and improved retrieval and end-to-end accuracy. The code is available at this https URL.
https://arxiv.org/abs/2606.27974