Sparse
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Task-Space Imitation Guidance for Efficient Reinforcement Learning
2026-10-05 23:49:17Salar Asayesh, Hossein Darani, Todd Cao, Evgeny Andriash, Mani RanjbarAbstract
We introduce Task-Space Imitation Guidance for Efficient Reinforcement Learning (TIGER), a reward-construction and pretraining framework for sparse-reward tabletop robotic manipulation. TIGER treats an action-chunked imitation policy not as an executable controller or action prior, but as a local task-space progress estimator: predicted action chunks are converted, using controller-aware action-to-motion mapping, into short-horizon end-effector references, and the RL agent receives dense progress rewards toward these references while the sparse environment reward remains the dominant objective. During pretraining, TIGER uses imitation-guided look-ahead signals to relax conservative value penalties for actions predicted to make task-space progress, reducing off-manifold exploration during early online RL. Across simulation and real-robot experiments, TIGER improves early sample efficiency and reduces measured safety violations while matching or improving final success rates relative to prior RL and IL-RL baselines on the evaluated tasks.
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https://arxiv.org/abs/2610.07527
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MARS: Multi-resolution Adaptive Routing for Sequential Recommendation
2026-10-05 23:14:39Ming Yin, Sixun Dong, Yudong Liu, Wen-Yun Yang, Yunjiang Jiang, Yiran ChenAbstract
Long-history recommenders often compress each user's history into a compact, candidate-independent memory that is cached and reused to score large candidate pools. We show that real user histories exhibit multi-scale semantic structure, with short-lived intent, medium-term interests, and long-term preferences coexisting in one sequence, and that monolithic cached memories preserve these scales unevenly: linear probes recover recent and mid-range content far worse than long-range content. We call this failure mode \textit{temporal aliasing}. We propose \textbf{MARS}, a multi-resolution user memory that writes the full history into recurrent state tracks anchored to different half-lives, and a sparse routing reader that materializes compact seed memories by selecting the relevant temporal resolutions for each seed, preserving fixed-size candidate scoring. MARS outperforms strong baselines on three public datasets, with gains that grow with history length. Component-matched ablations with paired tests show that temporal diversity and selective routing each contribute beyond what hard-window memories or added capacity provide. The advantage of MARS over its interface-matched baseline also widens after within-user behavioral shifts, at about $1.02\times$ that baseline's warm-cache serving latency for $1{,}000$ candidates per user.
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URL
https://arxiv.org/abs/2610.07505
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Inference and learning in sparse autoencoders as natural gradient flow
2026-10-05 21:03:21Hadi Vafaii, Tejas Rao, David Chanin, Thomas Fel, Jacob L. Yates, Bruno Olshausen, David Klindt, Dileep George, Miguel L\'azaro-GredillaAbstract
Sparse autoencoders are widely used to uncover interpretable features in neural networks, yet reliable recovery remains difficult when features overlap or activate infrequently. These challenges involve both inferring which features explain an input and learning the dictionary that represents them. Here, we unify inference and dictionary learning as natural-gradient flows on a shared variational free energy. We instantiate this framework as BeFOND, an encoder-free sparse coding model with closed-form inference and learning dynamics. We show how recurrent explaining away reduces interference between overlapping features, while Fisher preconditioning can compensate for the slow learning of rare features. On synthetic data, BeFOND improves dictionary recovery and rare-feature detection, with a growing advantage over amortized baselines as superposition increases. On language-model activations, it improves single-feature concept detection and selective intervention, outperforming pretrained reference SAEs with substantially less training data. Its feature quality continues to improve with dictionary width, whereas the evaluated baselines largely plateau. Together, these results show how improving inference and learning within a unified probabilistic framework can make better use of data and dictionary capacity to interpret and intervene on neural representations.
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URL
https://arxiv.org/abs/2610.07389
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Stepped MoE: Segment-Level Routing with Configurable Inference Complexity
2026-10-05 20:18:26Arnav Kundu, Zhaoyang Xu, Bairu Hou, Chang Gao, Reed Li, Tao LeiAbstract
Training large language models (LLMs) is resource-intensive, and adapting them for diverse deployment scenarios with varying computational constraints remains challenging. While elastic architectures enable flexible model deployment and sparsely activated models allow input-adaptive computation, existing approaches treat these dimensions independently. Moreover, models catered towards on-device edge inference need to conform to the memory and compute limitations of the serving devices. In this paper, we introduce a unified framework that combines elastic structures with sparsely gated architectures to create models that adapt simultaneously to both deployment constraints and task requirements. Our approach employs a model backbone that conditions on both the context and target efficiency specifications, enabling fine-grained control over the accuracy-efficiency trade-off at inference time. The model learns to activate task-relevant parameters within elastically-nested sub-networks, allowing a single model to span multiple capacity points while maintaining input-adaptive routing. Through experiments we demonstrate that we can create a model that allows the flexibility to use 1,2,3,4 billion parameters while being more accurate than their dense counter-parts (2-5\% on knowledge-intensive benchmarks) and at par with their static versions while delivering similar latency metrics as dense models. Overall, we save on device disk space by sharing the model parameters, allow flexibility of serving based on DRAM and compute available while delivering more accurate results.
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https://arxiv.org/abs/2610.07348
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CausalBind: Causal Modeling and Learning for Protein-Molecule Virtual Screening
2026-10-05 20:14:51Loka Li, Jin Tian, Kun ZhangAbstract
Protein-molecule virtual screening is increasingly cast as a problem of representation learning in a shared embedding space. Existing methods rely on dense holistic alignment, entangling invariant binding determinants with nuisance correlations and limiting transfer to new targets. It has been noted that binding in protein-molecule systems involves sparse cross-modality interactions: binding is governed by a small contact interface and a few decisive local interactions (e.g., hydrogen bonds, hydrophobic contacts, and salt bridges) rather than the global structures of the protein and molecule. We hypothesize that uncovering and leveraging sparse interaction patterns is critical for generalization beyond the training data, as these patterns are reusable and expected to improve performance across different scenarios. In this paper, we aim to identify and leverage sparse interaction patterns, and verify our hypothesis. Since the training data contain only observed binding pairs, we formalize this prior via a V-structure causal model under Heckman-style selection, and establish three theoretical results: (i) the latent concepts of interacting proteins and molecules are not identifiable without appropriate sparsity constraints; (ii) these concepts and their sparse interactions are component-wise identifiable under structural sparsity conditions; and (iii) a low-rank relaxation of these conditions yields subspace identifiability of the concepts and interactions. Inspired by these principles, we propose CausalBind with three implementation variants. Extensive experiments on DUD-E and LIT-PCBA benchmarks show that all variants consistently outperform strong retrieval baselines, with the largest gains on LIT-PCBA early enrichment, and further generalize to target- and scaffold-level out-of-distribution splits. Code is available at this https URL.
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URL
https://arxiv.org/abs/2610.07340
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Structuring MoE Expert Selection for Agentic Reinforcement Learning
2026-10-05 20:06:47Bolian Li, Ting-Yao Hu, Cheng-Yu Hsieh, Sanjoy Chowdhury, Oncel Tuzel, Raviteja VemulapalliAbstract
Long-horizon LLM agents are frequently implemented using sparse mixture-of-experts (MoE) models, yet the co-design of agentic behavior and MoE structures remains underexplored. In this work, we comprehensively study the connections between agentic post-training and MoE expert selection. In off-the-shelf MoE models, we observe expert selection exhibits a specialized structure that naturally aligns with agentic trajectories. Specifically, expert routing overlaps more between turns where the agent performs semantically similar operations (e.g., READ, UPDATE) than between turns with differing operations. However, standard RL algorithms ignore this specialization, allowing the MoE routing to go uncontrolled during training, which empirically limit task performance and inference efficiency. To address this, we introduce a hierarchical routing control framework for agentic tasks. We explicitly encourage turn-level expert selections to align with agentic operations while regularizing token-level expert selections to maintain local consistency. To resolve stability issues that arise during post-training with the proposed methods, we further introduce an entropy-gated control mechanism. Overall, our routing control framework achieves over 10-point improvements in success rate on all evaluated benchmarks. These results demonstrate that agentic trajectory structure provides an effective signal for optimizing MoE capacity during RL post-training.
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URL
https://arxiv.org/abs/2610.07332
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Cascadia: Resident 975B MoE Inference on Eleven AI PCs
2026-10-05 18:29:24Tate Berenbaum (Not Community Labs Inc.), Matias Parij (Not Community Labs Inc.), Muthaiah Venkatachalam (Intel Corporation)Abstract
Mixture-of-experts models make nearly trillion-parameter capacity accessible with sparse per-token computation, provided that the serving system can distribute the weights and coordinate their execution. We present Cascadia's resident execution of Inkling, a 975B-total/41B-active-parameter model, on eleven Intel Core Ultra X7 358H AI PCs, each with 64 GB of memory, Arc B390 integrated graphics and gigabit Ethernet. We contribute a custom resident MoE engine that preserves Inkling's routing rules, constructs compressed graphs for OpenVINO's fused iGPU primitives, and coordinates FP16 expert computation with FP32 output restoration. The engine fits six consecutive decoder layers per machine and represents dense feed-forward blocks as all-active expert slices, reducing measured dense-layer call time from approximately 8.1 to 4.5 ms. A streaming pipeline coordinates concurrent generation, while captured-state draft evaluation measures agreement with the deployed numerical path. Paired measurements at fifteen concurrency levels from 1 to 176 streams reach 60.29 aggregate decode tokens/s at 88 streams, with 46.87 tokens/s over the complete serving phases. At fifteen streams, median first-token latency is 6.05 s. Raising the context budget from the 1,024-position default, real prompts of 1k to 64k tokens recover the embedded code in all 19 measured answers, with first-token time growing as $aN+bN^2$ and decode latency growing approximately linearly, both bounded by a single-threaded CPU attention loop rather than by memory, which holds 512k positions per stream. Evaluation on captured fleet states separates the effects of vocabulary selection and weight quantization on draft agreement. Together, these contributions establish an execution and evaluation approach for large sparse models on distributed client systems with shared CPU-GPU memory.
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URL
https://arxiv.org/abs/2610.07219
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Distributionally Robust Mixture-of-Experts Training
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Mixture-of-Experts (MoE) transformers scale capacity by activating only a few experts per token, but this sparsity creates a hidden reliability problem: when routing is imperfect, load-balanced models may send tokens to experts that are insufficiently trained for the assigned inputs. We propose Distributionally Robust MoE Training (DRMoET), a drop-in objective that treats layer-wise experts as endogenous robustness groups and optimizes high-loss routing outcomes rather than merely equalizing traffic. DRMoET updates a per-layer expert distribution by an entropy-regularized softmax rule on EMA-smoothed, activation-weighted expert losses, strengthening plausible non-top routing paths while preserving standard MoE computation. Under the FLAME-MoE recipe at 746M-total and 10.3B-total scales, DRMoET improves downstream averages over both standard FLAME-MoE and auxiliary-loss-free balancing. At 10.3B total parameters and 67B training tokens, DRMoET improves the seven-task average from 0.6625 to 0.6767, while the auxiliary-loss-free baseline achieves 0.6431. Mechanistic analyses show lower expert-loss variance with nearly unchanged mean loss, 4.3% lower excess loss under forced mid-$k$ misrouting, and improved domain-expert specialization. These results position routing robustness-not only utilization balance-as a practical objective for reliable sparse MoE scaling. Project page and code are available at: this https URL.
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URL
https://arxiv.org/abs/2610.07207
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Agentic Design Space Exploration for Joint Hardware Configuration Selection and Mapping of AI Inference Workloads on Heterogeneous Edge SoCs
2026-10-05 18:08:58Geetha Prasuna Yarramneni, Surya Selvam, Wilfried Haensch, Anand RaghunathanAbstract
Modern edge Systems-on-Chip (SoCs) integrate heterogeneous processing units (PUs) such as CPUs, GPUs, and NPUs, each with distinct performance and energy characteristics. Deploying AI inference workloads on them under real-time latency and energy constraints requires jointly mapping workloads to PUs and configuring each PU (e.g., selecting the number of active cores and the operating frequency). This joint space grows combinatorially, making exhaustive search infeasible. Most prior work on design space exploration (DSE) applies black-box optimization (BBO) such as evolutionary search, where each evaluation returns only aggregate metrics such as latency and energy. Recent LLM-guided DSE relies on the same sparse feedback. We observe that this limits its efficiency: it offers no insight into the design space or the reasons a design choice performs the way it does, and it leaves the reasoning abilities of LLMs largely unused. We present TraceDSE, an agentic DSE flow that performs joint workload mapping and PU configuration selection for AI inference on heterogeneous SoCs. TraceDSE is an iterative proposer-critic loop driven by richer feedback in the form of system execution traces. The LLM proposer agent generates candidate mappings and PU configurations for hardware evaluation. The LLM critic agent, equipped with programmatic trace-analysis tools, analyzes the traces to identify bottlenecks and suggest targeted refinements. This loop yields deeper insight into each design point, higher-quality decisions, and a more effective search. Across four AI inference workloads (models of varying complexity and a multi-model pipeline) on an Intel Meteor Lake SoC, TraceDSE consistently outperforms two state-of-the-art BBO tools, improving Pareto frontier hypervolume by up to 35% over NSGA-II and up to 68% over Bayesian optimization, while requiring ~6-9x fewer hardware evaluations.
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URL
https://arxiv.org/abs/2610.07191
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AMBER: Training Long-Horizon Web Agents through Append-Only Memory
2026-10-05 17:11:07Chinmay Savadikar, Zhaoyu Zhang, Mingyu Zhao, Shuang Xie, Han Li, Tianfu Wu, Lingyun WangAbstract
Modern language-model agents increasingly interact with external environments over long-horizon, multi-step trajectories, where the accumulated interaction history can quickly exceed practical context budgets. To ensure reliability, agents must maintain factual information over long horizons, remember execution errors and corrective feedback, and track progress across actions. Several approaches have been proposed to achieve this without the need for maintaining the entire execution history in context, such as using the reasoning and action history, learning to maintain a fixed-size memory through an overwrite mechanism, and periodic summarization. Although overwrite memory can in principle retain anything an append-only memory can, it must learn to carry each fact through every subsequent rewrite, which is difficult to learn from sparse outcome rewards; for interactive applications like web agents, we find that trained overwrite memories delete key information required by the trajectory, as well as corrective feedback received from the environment. We introduce AMBER (Append-only Memory Bank for Evidence Retention) - a simple and scalable framework where an agent jointly learns to reason, act, and write free-form memory, while an append-only rule guarantees retention by construction. This allows AMBER to be trained end-to-end with reinforcement learning from outcome rewards without the need for extensive curated SFT data. On WebArena Lite, AMBER improves average success over overwrite-based memory by 4.09 percentage points, increases the fraction of tasks solved in five repeated runs by 4.8 percentage points, and matches an overwrite baseline trained on substantially more expensive curated supervision. AMBER achieves these improvements while maintaining a practical token budget, providing a strong balance between context efficiency, task performance, and reliable long-horizon execution.
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URL
https://arxiv.org/abs/2610.07118
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MoonGS: High-quality Representation of the Lunar Surface via Gaussian Splatting Using Robust Depth Features from Image Pairs
2026-10-05 15:46:50Yun Jiang, Bo Zheng, Yingying Zhang, Xueming Xiao, Tao Hu, Hutao Cui, Zhiguo Meng, Ke Gao, Yang Gao, Meibao YaoAbstract
High-quality 3D reconstruction of lunar terrain from sparse rover images is indispensable for autonomous lunar exploration, but remains challenging because viewpoint overlap is insufficient, surface textures are weak, and data volume is limited. We propose MoonGS, the first feed-forward 3D Gaussian Splatting framework tailored to lunar scenes. Given only two input images, MoonGS predicts pixel-aligned Gaussian primitives in a single forward pass and renders photorealistic novel views without any per-scene optimization. MoonGS (i) adopts an adaptable backbone design that seamlessly integrates advanced vision foundation models to extract robust depth features; (ii) integrates semantic priors in two manners: merging semantic cues with visual features to refine Gaussian parameter estimation, and adopting a semantic ranking loss that regularizes background depth; and (iii) employs an entropy-guided heuristic resampling strategy to augment sparse observations by selecting the most informative distant viewpoints with negligible overhead. Experiments on the LuSNAR benchmark and our synthetic weak-texture MoonBlender dataset show that MoonGS surpasses state-of-the-art feed-forward NeRF/3DGS baselines by +4.9 dB PSNR, +0.29 SSIM, and 40\% lower LPIPS while maintaining sub-second inference. Furthermore, we validate the broad applicability of our framework by demonstrating that it effectively leverages state-of-the-art backbones, including VGGT, to significantly boost performance. Qualitative evaluations on Chang'e mission imagery also show the best visual quality among compared methods, indicating robustness on real lunar data. The source code and dataset are publicly available at this https URL.
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URL
https://arxiv.org/abs/2610.07110
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SEAL: Mixture-Closed Additive Reconstruction and Refinement-Aware Expert Routing for Efficient Speech Separation
2026-10-05 02:22:41Shao-Chun Hu, Zi-Xiang Lin, Jeih-Weih Hung, Hung-Shin LeeAbstract
Compact time-frequency separators that mask the mixture and refine through a shared cell face two limits. First, a bounded multiplicative mask only scales a mixture bin, so where overlapping components cancel, the estimate stays small. Second, a shared cell applies the same weights to every time-frequency token at every step, so enlarging it adds compute everywhere. We present SEAL (Sparse Expert routing with Additive Latent reconstruction) to address both. For reconstruction, a zero-sum additive residual bounded by the local mixture amplitude lets estimates be nonzero where components cancel yet still sum to the mixture. For routing, a query built from acoustic and inter-step evidence sends each token to one of six residual experts, and a norm cap keeps the step cue from overriding clear acoustic evidence. On EchoSet, SEAL (small) surpasses TIGER (small) by 0.31 dB SI-SDRi with 28% fewer parameters and 2.9 times fewer MACs, and SEAL (large) is within 0.07 dB SI-SDRi of TIGER (large) at 3.1 times fewer MACs.
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URL
https://arxiv.org/abs/2610.07047
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Inference-Time Projection for Physically Valid Biomolecular Diffusion Models
2026-10-04 23:15:03Qurat-ul-ain, Yee Whye Teh, Charlotte M. Deane, Matteo CagiadaAbstract
AlphaFold 3-style cofolding models predict biomolecular complexes with high structural accuracy, yet a large fraction of their outputs are physically invalid: chains overlap at interfaces, ligand bond lengths and angles are distorted, rings are non-planar, and stereocentres are inverted. Current approaches either steer the sampler with physics-informed potentials, which multiplies sampling cost and memory overhead making inference impossible on large complexes, or finetune the model, costing time and tying the fix to one architecture. We observe that, unlike structural accuracy, physical validity is fully verifiable at inference time from quantities the sampler already holds. We therefore treat physical validity as a constrained inference problem and introduce two closed-form projection operators applied to the diffusion model's denoised clean-coordinate estimate, $\hat{x}_0$: an inter-chain van der Waals projection that pushes apart the most severely clashing atom pairs, and a ligand distance-geometry projection that restores bond lengths, angles, internal contacts, planarity and chirality. Both operators are local, sparse and displacement-capped, require no network evaluations, gradients or importance sampling, and leave the denoiser and its weights untouched, so they can be dropped into any AF3-style sampler without retraining. Applied to two independently developed models, Boltz-2 and OpenFold-3, across five benchmarks (CASP15, CASP16, the PoseBusters monomer and complex sets, and the Boltz physical-validity test set), our method recovers perfect physical validity while preserving structural-accuracy and ligand-placement metrics. These gains are achieved with negligible runtime and memory overhead, providing a practical, model-agnostic route to physically valid all-atom structure prediction.
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URL
https://arxiv.org/abs/2610.07037
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Hierarchy-GBP: Accelerating Factor Graph Inference via Abstraction and Recovery
2026-10-04 00:50:25Yuzhou Cheng, Tom Yates, Ignacio Alzugaray, Danyal Akarca, Pedro A. M. Mediano, Andrew J. DavisonAbstract
Gaussian Belief Propagation (GBP) is a distributed inference algorithm that passes messages in graphical models, making it attractive for scalable spatial intelligence. However, we find GBP most effective locally: it rapidly smooths message errors that vary sharply between neighbor variables, but corrects global errors across distant graph regions incrementally through long-range message propagations. We propose Hierarchy-GBP (H-GBP), an iterative, two-stage framework that accelerates GBP by first solving these global errors with a coarse graph approximation (abstraction) and projecting the results back to the original graph (recovery), then refining the remaining local errors with GBP. We prove H-GBP convergence to the optimum by deriving the combined matrix operator of our abstraction and recovery steps and analyzing its spectral radius. Experiments on linear sparse graphs show that H-GBP converges fundamentally faster than standard GBP. Moreover, we validate H-GBP on two important spatial problems: Pose Graph Optimization (PGO) and Bundle Adjustment (BA). H-GBP markedly accelerates large-scale PGO and achieves state-of-the-art runtime across all tested BA scales.
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URL
https://arxiv.org/abs/2610.06978
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Learning Modular Policy for Multi-Floor Object Navigation:A Factorized Framework for Diagnostic Study
2026-10-03 15:45:41Shichao Zhai, Shuhao Ye, Rong Xiong, Yue WangAbstract
Object-goal navigation (ObjectNav) in multi-floor scenarios presents a challenge due to sparse rewards caused by long-horizon decision-making. In this paper, we propose a diagnostic study based on a modular framework with an effective learnable policy to analyze failure factors in multi-floor scenarios. To achieve an effective policy for diagnosis, we design the hierarchical factorization policy that deconstructs a single global policy into an intra-floor exploration policy and an inter-floor switching policy. To providing an effective initialization for Reinforcement Learning (RL), the lightweight intra-floor policy is learned by distilling the exploration logic of Visual Language Models (VLMs). Under idealized assumptions, we show that the factorized policy is theoretically equivalent to a single global policy at the policy-representation level. Experiment results indicate that perception performance and stair climbing stability are the primary bottlenecks in multi-floor navigation.
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URL
https://arxiv.org/abs/2610.06958
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UniPro: Unified Multi-Mode Medical Image Segmentation from 2D Images to 3D Volumes via Propagation
2026-10-03 06:41:17Bangwei Guo, Yunhe Gao, Meng Ye, Yang Zhou, Difei Gu, Guoning Zhang, Leon Axel, Dimitris MetaxasAbstract
Medical image segmentation remains fragmented along two axes: segmentation paradigms and data dimensionality. Existing methods are typically developed separately for semantic, in-context, and interactive segmentation, and are further specialized to either native 2D images or 3D volumetric data. In clinical practice, however, segmentation workflows take many forms: a case may be initialized by semantic prediction, reference-guided segmentation, or user interaction. Regardless of how it begins, fine-grained refinement is naturally performed on 2D views; for volumetric scans, such 2D edits must propagate coherently to the rest of the volume. We present UniPro, a unified model that bridges segmentation paradigms and data dimensionality, using propagation to extend 2D segmentation to 3D volumes. Our key insight is that volumetric propagation and in-context segmentation share the same reference-conditioned prediction mechanism, differing only in whether the reference image-mask pairs come from other cases or from previously segmented neighboring slices. Building on this view, UniPro supports semantic, in-context, interactive, and propagation-based segmentation within a single slice-based framework, using class priors, reference exemplars, user clicks, and neighboring-slice predictions as mode-specific conditioning inputs. To improve propagation reliability, UniPro further incorporates bidirectional and 3D supervision to regularize slice-wise propagation beyond per-slice losses. Extensive experiments across diverse modalities and anatomies show that UniPro achieves strong performance across all segmentation settings, enabling annotation-efficient 3D segmentation from sparse 2D initialization and reducing slice-by-slice correction effort.
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URL
https://arxiv.org/abs/2610.06938
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Decoding the Functional Roles of Register and High-Norm Patch Tokens in Vision Transformers
2026-10-02 17:55:06Neel Varma, Andrew Rufail, Dipika Khullar, Vasu SharmaAbstract
Self-supervised Vision Transformers (ViTs), such as DINOv2, learn rich visual representations, but the functions of their internal tokens remain poorly understood. Recent architectures introduce dedicated register tokens to reduce high-norm out- lier patch tokens that emerge in background re- gions, yet the semantic and functional roles of both token types have not been fully established. In this paper, we analyze these roles by training sparse autoencoders (SAEs) on register-token and outlier-token activations in DINOv2. Using an automated interpretability pipeline, UMAP clus- tering, and CLIP-space cross-checks, we find that register-token features are more strongly associ- ated with high-level semantic concepts. Outlier- token features, by contrast, are more often associ- ated with lower-level structural, background, and texture-dominant patterns. Causal ablations fur- ther reveal a substantial functional asymmetry: disrupting top-activating register-derived features produces a 48.17% drop in representation cosine similarity, whereas disrupting outlier-derived fea- tures produces only a 0.31% drop. Together, our results provide evidence for token specialization in self-supervised ViTs.
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URL
https://arxiv.org/abs/2610.03698
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Transcriptome-informed multi-modal AI for predicting neoadjuvant therapy response from breast cancer biopsies
2026-10-02 17:52:57Jungkyu Park, Dhruva Biswas, Joseph Cappadona, Cerise Tang, Ken G. Zeng, Bartosz Machura, Chuwen Liu, Paolo Tarantino, Coral Omene, Francisco J. Esteva, Rohit Bhargava, Marcin Braun, Kamila Pa\'zdzierz, Jakub Czerwi\'nski, Hanna Roma\'nska-Knight, Albert Grinshpun, Bareket Daniel, Michele Buchinger, Frederick Howard, Piotr Wysocki, Brie Chun, Freya Schnabel, Rich Caruana, Jan Witowski, Krzysztof J. GerasAbstract
Scarcity of labeled data limits development of deep learning biomarkers in oncology. We develop a two-stage AI model predicting pathological complete response (pCR) to neoadjuvant therapy in breast cancer. The first stage learns the transcriptome from histopathology using 8,742 patients across 32 cancer types, corroborated by pathologist review and spatial agreement with measured expression. This simplifies the second stage to predicting pCR from inferred expression and clinical variables. Developed using 1,080 patients (five cohorts) and evaluated in 1,412 patients (nine cohorts), the model achieves a pooled AUROC of 0.79 (95% CI, 0.73-0.85), discriminating responders within molecular subtypes. It outperforms histopathological biomarkers, remaining stable across intratumoral sampling and with minimal biopsy tissue. Ablations show transcriptome-wide inference improves discrimination over clinical variables alone or one-stage pathology models, and robustness by avoiding genomic assays' gene selection constraints. These results indicate that biologically informed compression may generalize to data-sparse applications in precision oncology.
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URL
https://arxiv.org/abs/2610.03693
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ProAR: Learning Prospective Reasoning with Autoregressive Video Models
2026-10-02 17:37:47Linghui Shen, Tinghui Zhu, Sheng Zhang, Muhao ChenAbstract
Autoregressive (AR) video models excel at causal generation, but their reliance on next-chunk prediction confines them to a short-sighted, reactive paradigm. This limitation is particularly consequential for reasoning-oriented generation, where achieving a target outcome through valid intermediate states matters more than local visual plausibility. To address this challenge, we propose Learning Prospective Reasoning with Autoregressive Video Models (ProAR), a novel framework that transforms autoregressive video generation into a goal-oriented reasoning process. ProAR introduces two key components: (1) To anchor generation to the long-range outcome, we integrate goal-frame prediction into the autoregressive loop via an asymmetric attention mask, enabling the predicted goal frame to guide the generation of intermediate states without being disrupted by them. (2) To guide short-range transitions, we introduce future representation self-alignment to encourage current hidden states to anticipate upcoming temporal dynamics. By leveraging teacher-forcing in AR training, we extract clean future representations in a single forward pass and align current representations with them using a lightweight, training-only predictor. Together, these two mechanisms seamlessly combine explicit, sparse target supervision with implicit, dense step-wise guidance, promoting coherent, goal-directed reasoning progress with modest computational cost. Experiments show that ProAR's complementary components consistently improve performance across diverse visual reasoning benchmarks. The framework proves highly training-efficient, surpassing fully trained standard AR baselines using only 25% of the training steps. This paradigm also demonstrates promising applicability to embodied reasoning tasks.
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URL
https://arxiv.org/abs/2610.03664
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GAMEGO: Training Game-Dev Agents with Synthetic Trajectories Anchored in Real-World Assets
2026-10-02 17:05:07Haoyue Yang, Jingyao Li, Zhengfan Wu, Jing Liu, Xuanle Zhao, Kang LiuAbstract
Recent advances in Large Language Models (LLMs) have demonstrated remarkable capabilities in web front-end execution, with browser-based game generation emerging as a particularly prominent frontier. While previous efforts frequently rely on complex multi-turn workflows or focus on static game evaluation benchmarks, this work targets direct end-to-end real-world game synthesis driven by coding agents. However, generating complex games directly from sparse user queries often forces coding agents to make underspecified assumptions, yielding incomplete mechanics, disconnected gameplay flows, and limited visual aesthetics. To resolve this issue, this paper presents GameGo, a scalable framework that systematically transforms brief game seeds into comprehensive Product Requirements Documents grounded in industry game-development practices. To retain core gameplay constraints without restricting design exploration, GameGo uses task-specific dynamic compression to maximize information density while preserving instruction following. Based on this pipeline, GameGoData is constructed with 55,060 development trajectories across 2D, 2.5D, and 3D games, alongside GameGoBench, a benchmark comprising 124 diverse game queries. Training GameGoCoder on GameGoData yields a model that outperforms matched baselines and is comparable to frontier models across gamedev benchmarks. All code, datasets, and models will be made publicly available.
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URL
https://arxiv.org/abs/2610.06910
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