EHR foundation models promise scalable clinical prediction across health systems, yet their deployment is constrained by a tokenization bottleneck. The same clinical concept can appear as different ontology codes, local identifiers, synonyms, or free-text descriptions, which standard EHR tokenizers treat as unrelated symbols. A model trained on MIMIC-III with a closed-vocabulary tokenizer can use only 13% of eICU events. We introduce MEDIATOR, a discrete ontology-agnostic tokenizer that maps any clinical concept expressed as text into a shared vector-quantized codebook, turning EHR harmonization into open-vocabulary tokenization without manual mappings or a fixed vocabulary. Trained with synonym supervision and guided by enriched concept descriptions, code co-occurrence, and relation graphs, MEDIATOR collapses equivalent expressions while organizing distinct concepts in a medically meaningful discrete space. Used as the token interface of an EHR Transformer, MEDIATOR improves mean AUPRC over the strongest prior tokenizer by 4.0 points (8% relative) on 20 MIMIC-III tasks and by 8.6 points (29% relative) in zero-shot transfer to 14 eICU tasks, where it uses all events. The transfer gain combines coverage and representation, as MEDIATOR remains the best tokenizer under identical inputs (+1.0 and +1.9 points on operational and subcohort-mortality tasks). Same-encoder controls show that the text encoder drives in-domain accuracy, while the learned objectives of MEDIATOR drive transfer robustness and entity-linking quality. MEDIATOR also enables transferable attribution across hospitals.
https://arxiv.org/abs/2610.27047
Large language model (LLM)-based agents have recently demonstrated outstanding performance in single-turn tasks, yet they continue to struggle with long-horizon tasks, particularly in environments without prior training. A key limitation of single LLMs is their difficulty in processing long contexts, which stems from weaknesses in continuous decision-making and reasoning capabilities. Although existing multi-agent systems (MAS) equipped with long-term memory bases can partially address this gap, they mostly rely on knowledge reuse or summarization, an approach that is often constrained by directly retrieval without any adaptation for the current task, while the retrieved memory may contain much history noises waiting to be preprocessed. In contrast, MAS characterized by task-specific guidance often lack long-term memory specifically designed for the guidance. To address these challenges, we propose M-Plan, a closed-loop MAS framework that integrates long-term and short-term memory. By combining global-local and past-current guidance, M-Plan enhances agents' performance on multi-turn tasks while maintaining a plug-and-play design. During task execution, agents receive task-specific milestones and insights, and are provided with local hints only when confusion arises, which form global-local guidance together. These guidance generation and utilization construct the short-term memory as well. After task completion, relevant information about the current task is optimized or reorganized before being sent to the long-term memory storage for future retrieval. The designments mentioned above build a comprehensive framework different from other individual long-term or short-term memory works. Extensive experiments on multi-turn tasks including ALFWorld, Webshop, and PDDL across diverse models demonstrate that M-Plan outperforms multiple baseline methods in both accuracy and efficiency.
https://arxiv.org/abs/2610.27032
Existing benchmarks for text-vision embedding models report aggregate scores that obscure whether performance comes from general capabilities, task-specific adaptation, or robustness to challenging tasks. We introduce TRACE, a Training-aware Robustness and Challenge Evaluation framework that reorganizes 168 tasks from various sources of datasets into three categories: General, Adaptability, and Challenge. Through controlled experiments on two text-vision embedding models, we show that combining general and adaptation data improves Adaptability performance by 7.67 and 7.09 points, respectively, while largely preserving General performance. However, Challenge performance remains below 5.0, with limited improvements from additional training data. Further analysis identifies multilingual and visual-document tasks as major weaknesses. Our findings demonstrate that data adaptation alone is insufficient to address these challenges, highlighting the need for methodological advances beyond data-centric improvements.
https://arxiv.org/abs/2610.26993
Mixture-of-Experts (MoE) have become a mainstream way to scale Large Language Models (LLMs), because each token activates only a small subset of experts, reducing inference cost. However, MoE decode remains highly memory-bound and exhibits strongly skewed, time-varying expert loads. 3D-stacked DRAM near-memory processing (NMP) provides the bandwidth that decode demands, yet its tiled organization makes load balancing expensive: expert parallelism (EP) preserves locality but suffers from hotspot-induced imbalance, while more distributed strategies weaken locality and increase NoC traffic. To address this locality-balance conflict, we observe that domain-specialized token routing creates offsetting expert-load fluctuations across decode steps, a property we call expert complementarity. Using this insight, we propose 3D-MoE, a hardware--software co-designed system for MoE decode on 3D-stacked NMP. 3D-MoE uses offline, one-time complementarity-guided grouping and locality-aware mapping to establish coarse-grained inter-group balance, handles residual intra-group hotspots through a lightweight Collaborative Memory-Network (CMN) that streams each hot expert's weight tiles once from its host DRAM channel to helper cores over a reconfigured local broadcast path, and uses cost-aware online remapping to remain robust to workload drift. Across MoE models, 3D-MoE achieves an average 4.63$\times$ MoE-layer speedup over EP and improves end-to-end throughput by 1.58$\times$--1.86$\times$ over the strongest NMP baselines, with 2.11\% additional logic-die area.
https://arxiv.org/abs/2610.26991
Histopathology is central to cancer diagnosis, but morphology in Hematoxylin and Eosin (HE)-stained images does not directly reveal the molecular states that characterize disease heterogeneity and inform tumor characterization, prognostic assessment, and biomarker discovery. Spatial Transcriptomics (ST) measures spatially resolved gene expression, providing molecular information within tissue architecture, yet differences in assay coverage and spot informativeness make paired HE--ST observations unequally reliable for representation learning. We propose Reliability-Guided Spatial Transcriptomics (REST) supervision with Biological Program Bank (BPB), a program-structured and reliability-guided ST-supervised training framework for predicting molecular information from H\&E images. REST constructs BPB from curated signature, pathway, and cell-type gene sets to provide a shared structure for ST encoding, reliability estimation, and molecular reconstruction. Guided by BPB, Spot-Reliability Contrastive Alignment (SRCA) measures the reliability of each spot from assay-level program coverage and spot-level activity dispersion, and reweights HE--ST alignment accordingly. Biology-Informed Program Reconstruction (BIPR) further uses learnable program queries to reconstruct member-gene expression from histological morphology. REST's training corpus comprised 209 samples (407,475 spots across 16 organs); evaluation used 70 disjoint samples (230,056 spots across eight organs) for gene-expression, pathway-activity, and cell-signature prediction. REST achieved the highest Macro correlation among state-of-the-art ST-supervised training methods and outperformed existing pathology foundation models. Code is available at this https URL.
https://arxiv.org/abs/2610.26988
Large language model (LLM) agents tackle complex tasks through reasoning and interaction with external environments. Agent skills provide persistent, transferable capabilities that guide task planning, inform contextual decisions, support tool use, and enable executable procedures. Yet existing skill-evolution methods largely organize knowledge around skill artifacts, overlooking the functional heterogeneity within individual skills and its implications for knowledge maintenance and use. Inspired by cognitive science, we propose Cognitive Differentiation in Skill Evolution (CDSE), which evolves a unified skill through four functionally distinct yet coordinated components: Meta, Experience, Tool, and Script. CDSE extracts evidence-grounded semantic gradients from successful and failed trajectories, consolidates them by functional role, and applies component-specific updates and validation with cross-component coordination and adaptive invocation. An analysis of 500 top-ranked skill packages shows that 96.8% contain knowledge spanning at least two functional roles. Across six benchmarks, three agent models, and two execution harnesses, CDSE achieves the highest scores in all 36 settings, improving over the Base agent by 7.6 percentage points and the strongest competing method in each setting by 2.6 points on average. Ablation studies further support the importance of functional differentiation and adaptive invocation.
https://arxiv.org/abs/2610.23599
Time-aware retrieval is crucial for long-horizon LLM agents to effectively leverage ever-growing long-term memory. Existing methods focus on lexical or semantic similarity, leading to target memories being crowded out by temporally mismatched yet semantically similar candidates. Even time-aware approaches inject temporal cues only during memory organization or answer generation, overlooking temporal constraints at the retrieval stage, where candidate selection occurs - the root cause of the displacement. Inspired by the temporal contiguity effect in human episodic memory, we propose TIDER (Temporal Interval-driven Dual-channel Evidence Retrieval), a time-aware agentic retrieval framework. Central to TIDER is a reinforcement learning (RL)-trained temporal interval locator that infers the temporal windows in which the evidence lies. RL optimizes window localization as a discrete, non-differentiable retrieval decision, using composite rewards to convert sparse answer supervision into fine-grained retrieval feedback. These temporal windows first define the temporal retrieval channel; the retrieved candidates are then merged with results from the semantic channel and reranked by proximity to the windows. This temporal grounding enables TIDER to retrieve temporally aligned evidence that would otherwise be drowned out by the volume of semantically similar yet temporally mismatched memories. With a lightweight 1.7B locator, TIDER achieves state-of-the-art accuracy on both long-horizon memory benchmarks - 61.52% on LifeBench (+8.82%) and 78.96% on LoCoMo (+3.66%) - which indicates that temporal cues are crucial for pinpointing target evidence amid a vast pool of semantically similar historical events in long-term daily-life memory.
https://arxiv.org/abs/2610.23598
Audio-driven lip synchronization aims to match target speech through localized mouth and jaw articulation while preserving subject identity, head pose, and surrounding facial context. Naturally recorded videos provide synchronized reconstruction targets but rarely offer pairs that are matched in identity and pose yet differ primarily in speech-related articulation. Mask-based training enables reconstruction from these videos, but random-reference inputs differ from the aligned self-reference used at inference. We present LiveSync, an iterative self-training framework in which a single mask-based model generates pseudo pairs and is refined for deployment. The model is first trained on a curated real-video corpus augmented with externally generated clips covering under-represented visual conditions. A frozen checkpoint then uses independently sampled audio to generate mouth-edited references from real-video frames, copying pixels outside the edit mask from each source frame. After confidence filtering, these references are paired with aligned masked inputs and original real-frame targets. The retained pseudo pairs are mixed with real training data to refine the same model from its current weights, updating training supervision without adding inference stages. Although we instantiate the framework with a single-pass GAN-based model, the self-training strategy could in principle also be adapted to diffusion-based models. Experimental results show that LiveSync achieves leading synchronization performance on HDTF and competitive performance compared with the baselines on the AIGC-LipSync subset, while maintaining low inference latency.
https://arxiv.org/abs/2610.23558
Recent image generators exhibit rich visual priors that can support dense visual perception. However, existing approaches typically encode multiple perception tasks into a shared parameterization, making joint training sensitive to the mixture and weighting of heterogeneous data and prone to cross-task interference. To address this issue, we introduce ReVision, an instruction-conditioned parameter generation framework built on a frozen multimodal understanding model and a frozen image generator. Given an image and a free-form instruction, the understanding model jointly encodes them into a multimodal image--instruction representation, which a trainable parameter generator maps to transient low-rank updates for the generator. Each image--instruction pair induces a distinct set of transient prediction parameters, enabling instance-specific adaptation while both pretrained backbones remain unchanged. ReVision requires no task-specific heads, explicit task identifiers, or stored adapters. A shared RGB output interface unifies segmentation, depth estimation, and surface-normal prediction. Across diverse dense prediction benchmarks, ReVision achieves competitive performance with state-of-the-art methods while supporting flexible task specification through natural-language instructions. Our analysis further reveals substantial gradient disagreement across tasks, highlighting the conflict introduced when heterogeneous objectives share a single parameterization. Meanwhile, the generated updates exhibit structured task- and input-dependent organization in weight space, further validating instance-level parameter generation for multi-task perception.
https://arxiv.org/abs/2610.23533
AI agents have increasingly interacted with external environments by invoking tools, with Model Context Protocol (MCP) emerging as a standard interface for connecting agents to heterogeneous tools and services. As organizations deploy agents at scale, MCP gateways have become a critical middleware layer for aggregating, governing, and shaping the tool surface exposed to agents. Despite the growing importance of MCP gateways in agentic systems, no prior work has systematically studied how gateway design affects agent capability, efficiency, and security. To address this gap, we introduce GatewayBench, the first unified evaluation framework and benchmark for MCP gateways. We characterize gateway architectures into two major paradigms: flattened gateways and hierarchical gateways. GatewayBench comprises 524 tasks across six domains, together with a pool of 11,118 real-world tools from 251 authentic MCP servers. To emulate large-scale deployments, we systematically inject task-irrelevant tools sampled from this pool into each agent environment, enabling controlled evaluation as the accessible tool surface scales. Based on GatewayBench, we conduct extensive experiments across seven widely deployed MCP gateways and diverse agent configurations, covering both benign and adversarial tasks. Our results reveal substantial differences across gateway designs in task completion, tool-use efficiency, and resilience to attacks, and further demonstrate that these effects interact strongly with the underlying model and agent harness. These findings highlight the MCP gateway as a consequential yet underexplored component of the agentic AI stack. By enabling controlled evaluation of gateway architectures under realistic tool ecosystems, GatewayBench provides both practical guidance for MCP gateway design and a rigorous testbed for developing more capable, efficient, and secure agentic systems.
https://arxiv.org/abs/2610.23449
Lithography process drift can move a fabricated pattern outside its process window, producing unqualified scanning electron microscopy (SEM) morphology. We present LithoWorld, an endpoint world model for SEM-guided parameter recovery. Interior representative targets jointly determine qualified reference appearance and correction supervision. A causal predictive branch aligns currentimage features with endpoint representations, while a conditional flow policy generates a two-dimensional correction as an action chunk. The model learns from 173 groups of measured SEMs organized as focus-exposure maps, preserving unmeasured cells as unknown. On 200 test pairs from the 73-group subset, LithoWorld achieves 88.5% qualified-region success and 46.0% interior success, exceeding the strongest comparison method by 2.5 and 6.0 percentage points, respectively. Ablations separate the effects of target selection, endpoint alignment, and output parameterization. Qualitative SEM retrieval illustrates recovery to qualified interiors without requiring exact reference-coordinate matching.
https://arxiv.org/abs/2610.23408
This study investigates CT-to-PET image synthesis using TransNSNet, a Transformer-enhanced multi-scale adversarial framework. A paired CT-PET dataset was curated from the public non-small cell lung cancer (NSCLC) Radiogenomics collection through patient screening, slice-level matching, preprocessing, and patient-level train-test separation. The proposed framework generates PET-like predictions at multiple spatial scales and applies coarse-to-fine reconstruction supervision, while TransPatchGAN introduces contextual feature interaction into adversarial evaluation. A progressive ablation study compares Pix2Pix, NSNet-Base, NSNet-D, and TransNSNet. Image-level performance was summarized over a fixed convergence window (epochs 80-101) from one training run per model. TransNSNet achieved the best mean value in nine of ten metrics, whereas NSNet-Base achieved the highest visual saliency-induced index. For fixed-fraction high-intensity regions, NSNet-D was marginally higher in slice-level recall and balanced accuracy, but the equal-weight patient-level values were nearly identical and the highest Dice values shifted to TransNSNet. These differences were small relative to between-patient variability. In the separate adaptive patient-level analysis (n=10), no pairwise model difference remained statistically significant after Holm correction. TransNSNet also had a substantially smaller parameter footprint than the original next-scale models. These findings indicate promising image-quality trends, but they do not establish statistical superiority or clinical validity; synthesized PET-like images should not be interpreted as substitutes for clinically acquired PET.
https://arxiv.org/abs/2610.23325
Enterprise data analysis requires agents to connect analytical requests with knowledge distributed across databases, business documents, and existing example tasks. Without an explicit representation of this knowledge, an agent may produce incorrect analytical results and cannot reliably incorporate feedback. We present AgentOnto, an ontology-guided LLM agent for enterprise data analytics. AgentOnto organizes heterogeneous enterprise knowledge into an ontology that directly guides analysis and incorporates confirmed feedback. Iterative Ontology Preparation further improves the ontology through self-generated analysis tasks. We evaluate AgentOnto on two public data sources. AgentOnto substantially outperforms representative methods, while module-level evaluations confirm the effectiveness of ontology construction, analysis, and updating. A real-world deployment further demonstrates its practical value in enterprise analytics. These results demonstrate that explicitly constructing, using, and updating enterprise knowledge supports reliable and adaptable data analysis.
https://arxiv.org/abs/2610.23317
Large language models (LLMs) can generate fluent outputs that lack source support or conflict with local operational constraints. We introduce Self-Reflective Chain-of-Thought (SRCoT), a modular architecture that organizes generation as a closed Retrieve--Reflect--Revise loop. SRCoT separates environment state, persistent knowledge, accumulated experience, and short-term memory into provenance-labeled stores. BM25 retrieval supplies local context; subsequent passes expose intermediate drafts, missing-information markers, follow-up queries, and optional claim--evidence mappings. These artifacts inform retrieval, revision, clarification, or abstention decisions. We examine the architecture through qualitative, trace-based case studies in two fully synthetic settings: emergency medical services and Munich-Sim, an emergency-operations simulation. Local prototype runs on an Apple M4-family laptop with 128 GB memory illustrate source-labeled documentation, explicit gap marking, and structured dispatch-style outputs. The traces also reveal provenance-assignment errors, incomplete evidence coverage, and unsafe assumptions that remain possible despite prompting constraints. These cases demonstrate report-level inspectability and local execution, not comparative superiority, hallucination reduction, clinical validity, or operational safety. The architecture separates retrieval and control from the model interface, but behavior across different models remains to be evaluated. SRCoT is a research proof of concept requiring human review, with its principal contribution lying in an inspectable control procedure rather than a new model.
https://arxiv.org/abs/2610.23311
Enterprise data assistants using large language models (LLMs) promise democratized data access in organizations. Yet in our real-world deployment within the CFO unit's data lake at an industry partner, we observed that business users frequently pose imperfect prompts that include domain-specific vocabulary and lack schema references or structural information. This Design Science Research study examines automatic resolution using a semantic mediation layer. We design and evaluate two design variants: schema-based mediation via semantic similarity, and knowledge graph-based mediation leveraging an automatically constructed knowledge graph from the data lake. Our simulation-based evaluation using real-world data, supported by LLM-as-a-Judge assessments and human validation, shows that knowledge graph-based mediation outperforms the schema-based approach in Precision, Recall, F1, and preserving user intent. We propose a design principle for knowledge graph-based mediation, demonstrating that structured knowledge representation bridges user intent and database structure and guides the design of enterprise data assistants across skill levels.
https://arxiv.org/abs/2610.23304
AI agents increasingly use files and software tools to produce professional deliverables. Such work draws on materials, decisions, and feedback accumulated across assignments. We introduce OfficeTown, a generative simulation framework for professional organizations in which tasks and their context arise from continuing organizational work. From a natural-language description of an organization's purpose and activities, OfficeTown initializes an organization whose members coordinate work, delegate bounded assignments to assistant agents, and review their deliverables. Artifacts, decisions, and unresolved matters persist and shape subsequent work, while responsibilities and permissions determine what each member can see and do. We curate work requests, their context, and review feedback into executable resources for evaluation and learning. We construct OfficeTown Bench with 406 tasks and 4,836 evaluation criteria from 23 simulated organizations across eight professional domains, incorporating domain-expert feedback. Frontier-model evaluations reveal substantial remaining headroom. Supervised fine-tuning and on-policy distillation on OfficeTown data substantially improve Qwen3.5-9B on external professional-work benchmarks, including GDPval. Supplementary evaluations show that the principal--assistant harness achieves higher scores than the single- and multi-agent baselines tested. These results highlight the value of organizational simulation in generating work-grounded data and environments for the continued development of generalist agents.
https://arxiv.org/abs/2610.23194
Generative models for deepfakes have rapidly evolved from GAN-based architectures to diffusion models and multimodal large language models (MLLMs). However, empirical research on human performance in detecting deepfake face images has not kept pace. It remains unclear if (and how) detection performance varies across generative models and whether model-specific training improves detection more effectively than general-purpose training. In this paper, we propose the \emph{Deepfake Face Artifact Taxonomy} (DFAT), a cross-model taxonomy of human-recognizable visual artifacts in deepfake face images, based on which we build both general-purpose and model-specific training materials. Through an online experiment ($n = 524$), we examined human performance in detecting deepfake face images and evaluated training efficacy across five representative generative models: three GAN-based, one diffusion-based, and one MLLM (GPT-5). Our results show that participants' detection accuracy was strongly model-dependent and that images generated by more recent and advanced models were not necessarily harder to detect. After training, participants achieved significant performance gains across most conditions, and their improvement varied by model. Notably, model-specific training generally yielded greater numerical gains than general-purpose training. In a five-month follow-up test ($n = 342$), we observed no significant decline in detection accuracy and no significant increase in perceived stress. Overall, our findings provide actionable insights for designing effective, sustainable, and targeted training programs to counter the growing threat posed by deepfakes.
https://arxiv.org/abs/2610.23144
Humanoid control requires coordinating whole-body posture with position and heading in the world frame. Mainstream controllers imitate trajectories in the root frame, but struggle to regain the target world pose after displacement. We introduce BeJEPA, a goal-conditioned Behavior World Model learned through unsupervised reinforcement learning from human motion priors and robot interaction. BeJEPA learns a shared representation of body configuration and world placement through a joint-embedding predictive architecture (JEPA). A Dynamic Predictor predicts the next state embedding under an action, while a Successor Predictor summarizes a goal-conditioned policy's expected discounted future state embeddings in a single vector. During joint training, Dynamic grounds the initial representation in observed physical transitions, while Successor increasingly organizes it around long-term behavior. Their composition guides policy improvement through one physical prediction and one behavioral summary, without long imagined rollouts. In 20-second motion-tracking experiments, BeJEPA with online action refinement using Dynamic outperforms all evaluated baselines in global body-position error, reducing it on AMASS by 61.7% relative to BFM-Zero with world-pose inputs and 58.7% relative to SONIC. Physical deployment on a Unitree G1 demonstrates joint attainment of posture, world position, and heading goals, recovery from the ground, and closed-loop return after disturbances and goal changes. Project page: this https URL.
https://arxiv.org/abs/2610.23127
Recent RGB-infrared multi-object tracking (MOT) methods have substantially improved cross-modal representation learning and multimodal information integration. However, most existing methods compress RGB and infrared evidence into a unified descriptor. When one modality is temporarily degraded, the tracker can no longer regulate its contribution separately; unreliable evidence may distort association and contaminate appearance memory. We therefore propose RCA-MOT, a reliability-consistent appearance modeling framework that preserves cross-modal complementarity while retaining post-representation evidence controllability. RGB-specific, infrared-specific, and fused identity representations are maintained as jointly accessible appearance states. For each detection, a simple training-free target-scene estimator produces branch-wise appearance reliability used across the two temporal roles of appearance: relative reliability regulates different identity branches, absolute reliability calibrates borderline candidates near the ReID acceptance boundary, and the same branch-wise reliability controls how strongly matched descriptors update historical appearance memory. The individual components are intentionally simple, focusing evaluation on reliability-controllable appearance organization rather than elaborate fusion or learned reliability-estimation modules. RCA-MOT sets new SOTA results on VT-MOT and UniRTL, improving the previous best HOTA by 5.402/6.075 points and IDF1 by 11.549/12.789 points, respectively, while post-hoc analyses further validate reliability as an informative control signal. Code will be released upon acceptance.
https://arxiv.org/abs/2610.23125
Heterogeneous robot teams enable complex, long-horizon tasks by combining complementary sensing, mobility, and manipulation capabilities across multiple embodiments. Yet existing systems struggle to retain execution-time corrections as reusable experience, maintain task-relevant context memory across space and time for reliable handoffs, and explicitly represent the inter-robot dependencies required for structured collaboration. In order to address these challenges, we present InstAgent, a recursively self-improving (RSI) Agent Operating System for heterogeneous robot collaboration. InstAgent organizes team behaviors as agentic behavior trees (BTs) that explicitly model capability assignment, inter-robot dependencies and handoff checks. The RSI mechanism updates these collaboration programs from execution feedback and preserves successful revisions for reuse in future tasks, while shared multimodal spatio-temporal memory provides context for planning and handoff validation. Experiments on 20 real-world multi-robot tasks with three high-level models show consistent gains in task success, first-attempt completion, and execution efficiency.
https://arxiv.org/abs/2610.23098