Longitudinal medical imaging analysis is a cornerstone of modern medical practice and patient care. Deep learning applied to longitudinal imaging offers wide potential to enhance diagnosis and track disease progression by capturing spatial changes over time. With major advances in single-timepoint deep learning for imaging, there has been growing interest in longitudinal image analysis, given its increased clinical relevance, though technical challenges remain. Several recent innovations may lead to a new era of multi-timepoint image evaluation, yet the scientific landscape, recent progress, and areas of need remain under-characterized. To address this gap, we conducted a scoping review of deep learning methodologies applied to longitudinal medical imaging, yielding 102 studies published between 2018 and 2025. Neurological disorders (48%) and ophthalmic conditions (12%) were the most common clinical applications, with MRI serving as the predominant imaging modality (67%). Sequential feature modeling approaches combining convolutional neural networks (CNNs) with temporal models (LSTM/RNN) were the most frequent methodology (40%), followed by direct feature aggregation across timepoints (23%). Most studies targeted classification tasks (56%), while external validation was performed in only 24% of studies. Our findings highlight that deep learning-based longitudinal imaging analysis remains a promising field, though newer temporal architectures and larger datasets may improve success and clinical adoption of these tools.
https://arxiv.org/abs/2610.08838
Colorectal cancer (CRC) is the second most deadly and third most common cancer, and the leading cause of death among gastrointestinal cancers. Early diagnosis is crucial for the treatment of this cancer and increasing the survival rates. Although CRC is more common in developed regions, its occurrence is also increasing in developing regions as well. CRC diagnosis relies on histopathology assessment post-biopsy. Automated deep learning algorithms can significantly reduce diagnosis time, enhancing efficiency and supporting timely clinical decisions. We present an automated segmentation pipeline for whole-slide histopathology images that labels tumor grades 1-3 and normal mucosa. It utilizes dense prediction transformers with various encoder backbones, overlapping patches, and test-time augmentation. An adaptive augmentation policy, guided by large language models, further improves training. Top models were ensembled via soft voting, and mask refining post-processing steps, Gaussian blurring, morphological closing, and connected components analysis. On a colorectal cancer grade dataset, our method improved the F1 score from 62.92 to 69.84. Code is available here: this http URL
https://arxiv.org/abs/2609.38419
Physics-Informed Neural Networks (PINNs) embed governing equations into deep learning, but enforce them only through loss residuals, leaving highly oscillatory wave behavior to be discovered by optimization. As a result, methods that achieve relative $L_2$ errors below $10^{-3}$ on standard manufactured Helmholtz benchmarks can fail on practical radiation problems involving singular excitations, absorbing boundaries, and wave fields spanning tens of wavelengths. Architectural physics embedding addresses this limitation by factorizing the field into analytically derived oscillatory kernels and learnable envelopes. However, the kernel dictionary must be manually constructed and scales with the number of elementary units, growing exponentially with the depth of hierarchically structured systems such as antenna arrays and metasurfaces. We propose PE-EK-PINN (Physics Embedded with Evolving Kernels), which treats physics kernels as reusable learned representations rather than fixed analytical inputs. A converged subsystem field is frozen and promoted to an evolved kernel, whose transformed copies are reused to represent higher-level configurations without deriving new governing equations. The resulting hierarchy makes the peak number of active kernels independent of system size and reduces cumulative training cost from $O(N)$ to $O(\log N)$. Experiments on dipole arrays, composite line-source geometries, and cross arrays demonstrate the dramatic training cost reduction, while achieving a reduced or comparable relative $L_2$ error. One notable example is PE-EK-PINN solves a $256$-dipole array more than 30 times faster than direct PE-PINN.
https://arxiv.org/abs/2609.38023
Brain networks characterize structural and functional relationships among brain regions and support research on cognition, brain disorders, and brain-computer interfaces. Their time-varying topology and higher-order spatiotemporal dependencies are not adequately represented by conventional static networks. Existing tools primarily focus on static connectomes and provide limited integration of dynamic network modeling with modern graph and sequence learning methods. We present BrainNet Studio, an integrated toolkit for static and dynamic brain network analysis. It provides a unified workflow encompassing network construction, feature extraction, predictive modeling, candidate biomarker identification, visualization, and assisted interpretation. The toolkit integrates 27 algorithms, including deep learning, graph neural networks, and spatiotemporal sequence models, to support classification and the identification of discriminative brain regions and connections. A large language model generates researcher-verifiable summaries of functional connectivity, structural connectivity, and structure-function coupling at individual and group levels. Within a consistent computational framework, users can configure analytical tasks, compare methods, inspect outputs, and extend functionality without repeatedly assembling application-specific pipelines. BrainNet Studio provides a practical and extensible platform for connectome analysis in cognitive neuroscience, exploratory studies of brain disorders, and brain-computer interfaces. The toolkit is publicly available at this https URL.
https://arxiv.org/abs/2609.37956
Raindrops adhered to camera lens or windshield are inevitable in rainy scenes and can become an issue for many computer vision systems such as autonomous driving. Because raindrop appearance is affected by too many parameters, therefore it is unlikely to find an effective model based solution. Learning based methods are also problematic, because traditional learning method cannot properly model the complex appearance. Whereas deep learning method lacks sufficiently large and realistic training data. To solve it, in our work, we propose the first photo-realistic dataset of synthetic adherent raindrops for training. The rendering is physics based with consideration of the water dynamic, geometric and photometry. The dataset contains various types of rainy scenes and particularly the rainy driving scenes. Based on the modeling of raindrop imagery, we introduce a detection network which has the awareness of the raindrop refraction as well as its blurring. Based on that, we propose the removal network that can well recover the image structure. Rigorous experiments demonstrate the state-of-the-art performance of our proposed framework.
https://arxiv.org/abs/2609.37870
Time series imputation has progressed from statistical and deep learning approaches to diffusion-based models, which have shown strong recent performance. Existing diffusion-based methods typically condition the reverse process using local contextual information from the current or neighbouring windows. Meanwhile, global dataset-level structure often remains implicit, limiting performance when local observations are sparse, noisy, or unrepresentative. To address this issue, we propose ProCTI, a diffusion-imputation framework that augments local conditioning with retrieved global dataset-level priors through learned prototypes. A hybrid conditioning mechanism integrates this global context with local signals during reverse diffusion, enabling more accurate reconstruction under varying missingness scenarios. Experiments across multiple benchmark datasets show that ProCTI outperforms strong baselines overall under random missingness, while remaining competitive under attribute-wise missingness. Furthermore, we use a latent-regime data model to characterise the precise conditions under which prototype-derived global conditioning provably improves imputation. We support this with a general theoretical analysis of local-global conditioning.
https://arxiv.org/abs/2609.37632
Supervised deep learning has advanced sparse-view tomographic reconstruction. However, conventional models, which typically map filtered back-projection (FBP) images or sinograms to clean reconstructions, are brittle under distribution shifts. Because they require retraining whenever projection counts and angles, detector resolutions, or data distributions change, their deployment in real-world applications remains limited. To address this, we introduce TomoTransformer, a transformer-based architecture that treats each \textit{local} filtered projection as an individual token and predicts missing views via self-attention. Crucially, TomoTransformer operates in a \emph{back-projection space} that separates projections across spatial locations, making view interpolation geometrically well-posed and invariant to detector size. This design yields a single foundation model that can process any number of input projections, at arbitrary angular locations and detector dimensions, and query any number of target angles without retraining. Trained on a large-scale dataset spanning diverse medical CT anatomies and natural images, TomoTransformer generalizes effectively across anatomies, materials, and resolutions. Extensive evaluations on several benchmark sparse-view datasets show that TomoTransformer significantly outperforms concurrent multi-purpose models like ViewTrans and matches or exceeds strong protocol-specific baselines, while remaining fully agnostic to the number of input and target projections. Furthermore, the model demonstrates robust zero-shot generalization on real experimental nanoscale brain data collected from an X-ray synchrotron, showcasing its practical utility for real-world applications.
https://arxiv.org/abs/2609.37605
As a fundamental image processing task, object Re-Identification (ReID) aims to retrieve objects across non-overlapping cameras. Recently, with the development of deep learning, significant advancements have been made in object ReID. However, most existing methods suffer from generalization due to the limited size and diversity of ReID datasets. Meanwhile, current models tend to focus on extracting semantic patterns rather than learning identity-aware feature distributions. To address these issues, we propose a novel feature learning framework named \textbf{DiffReID} for object ReID. It leverages a discriminative diffusion model to gradually learn identity-aware distributions and generate identity-invariant features. More specifically, with the Contrastive Language-Image Pre-training (CLIP) model, we first obtain identity-aware text features by prompt tuning. Then, we propose a Vision-guided Noise Generator (VNG) to initialize probabilistic noises and gradually corrupt identity-aware text features. Afterwards, we take visual features as conditions and propose a Light Weight Denoiser (LWD) to denoise the corrupted text features step-by-step for identity-aware distribution learning. To obtain discriminative features, we further generate identity-invariant guided features from randomly sampling visual-guided noises. Finally, we propose a Mutual Enhancement Constraint (MEC) to facilitate mutual learning between visual features and guided features to enhance the representation robustness and discrimination. Extensive experiments on five object ReID benchmarks demonstrate that our method shows better results than most state-of-the-art methods. The source code is available at this https URL.
https://arxiv.org/abs/2609.36894
Percutaneous iliosacral screw fixation is an important minimally invasive treatment for unstable pelvic fractures. Because the sacroiliac region has complex anatomy and narrow screw corridors, the accuracy and safety of screw placement directly affect surgical outcomes. Accurate and reliable preoperative screw planning is therefore essential to improve surgical success and reduce intraoperative risks. Conventional preoperative planning typically requires surgeons to determine screw trajectories through manual measurements, a labor-intensive process that depends on subjective clinical experience. To address these challenges, we propose a fully automated pipeline for preoperative iliosacral screw planning in patients with pelvic fractures. Using patient-specific three-dimensional anatomy, the pipeline automatically identifies safe screw corridors and generates individualized insertion trajectories to support clinical preoperative planning. We evaluated the proposed pipeline on 200 clinical cases of pelvic fractures. Compared with conventional manual measurements, the safety margin of the safe insertion corridors increased by 2% across the four screw types, the mean planning time decreased by more than 90%, and the clinical acceptance rate reached 95%.
https://arxiv.org/abs/2609.36847
The use and applicability of artificial intelligence (AI) in medical research and clinical practice has received increasing attention in the literature over recent years. The emergence of large language models (LLMs) has expanded discussions in regards to applications of AI within healthcare. While traditional deep learning based AI applications in medicine have often focused on specific and defined tasks, LLMs offer broader capabilities and flexibility in working with available data,. At the same time of writing, the integration of LLMs into medical settings raises important questions regarding their reliability, accuracy, transparency, safety, and appropriate role in a medical setting. This text presents and discusses recent talks and articles concerning the application of LLMs in medicine, with particular emphasis on their potential utility in research and clinical practice. It considers both the opportunities offered by these technologies and the challenges associated with their implementation, aiming to provide a perspective on the current and emerging role of LLMs within the medical field.
https://arxiv.org/abs/2609.34780
The vocal tract is the region of the human body responsible for filtering one's voice to create speech. In this paper, we present a differentiable and GPU accelerated acoustic simulator for the vocal tract. The differentiable simulator synthesizes speech by propagating sound along an acoustic tube model of the vocal tract, and via its gradients, can solve the inverse problem: reconstructing the shape of the vocal tract solely from the sound it produces. Although the inverse mapping between geometry and sound is notoriously non-convex, we discover that gradient descent succeeds with three technical contributions: (1) we design a frequency domain formulation of the vocal tract's fluid dynamics that is 70x more GPU parallelizable than finite differences in time, (2) we integrate a differentiable model for turbulence to synthesize consonants, and (3) similar to prior work in implicit neural representations (INRs) and neural fields, we find that parameterizing the geometry with a neural network accelerates convergence and escapes local minima that trap discrete representations. Because the simulator is differentiable, it is readily integrated with other deep learning pipelines to enable novel linguistics and medical imaging applications. (1) We demonstrate self-supervised autoencoding of vocal tract shapes across 11 languages, and (2) we couple our simulator with a generative model of MRI (magnetic resonance imaging) images to reconstruct one's moving vocal tract from only their speech without paired data.
https://arxiv.org/abs/2609.36737
Multivariate time series forecasting (MTSF) is critical across many real-world domains. Existing deep learning approaches fall into two paradigms with distinct limitations: channel-independent (CI) methods unconditionally ignore cross-variable dependencies and model only temporal dynamics, while channel-dependent (CD) methods consider both but typically rely on architectural compromises to mitigate overfitting and computational overhead. We therefore propose Chameleon, a specialized CD state space model (SSM) that enables data-dependent, fine-grained interactions across variables while scaling linearly with their number. By connecting selective SSMs with the Kalman filter, we leverage the missing measurement update in the former for cross-variable modeling while preserving the SSM backbone for robust temporal modeling. We further identify favorable inductive biases of GatedDeltaNet for time series, adapt it as our backbone, and improve generalization through additional techniques, including a previously unexplored stochastic perturbation of reversible instance normalization. On strongly dependent ODE and PEMS datasets, Chameleon achieves the best MSE and MAE across all settings, while its CI ablation and prior CD methods incur 61-178% higher MSE on average. Across 28 standard benchmark settings, Chameleon also achieves better MSE and MAE than each baseline in at least 27 and 22 cases, respectively. Training-time and peak-memory analyses on Traffic and ETT further demonstrate competitive efficiency and favorable memory scalability across different variable counts.
https://arxiv.org/abs/2609.36453
Deep learning classifiers for dermoscopic skin lesions often reach high in-distribution accuracy while quietly relying on spurious background cues such as skin tone, device vignetting, and embedded rulers, rather than on lesion morphology. This undermines robustness and fairness across skin tones. This work asks whether Explainable AI (XAI), typically used only to audit a finished model, can instead be repurposed as an active training signal that corrects this shortcut without sacrificing diagnostic accuracy. We introduce CAMEO (Class Activation Mapped Equitable Overlay), a framework that improves skin-lesion classification by selecting stable model explanations and using them to separate lesions from their backgrounds. It then replaces the background with realistic synthetic skin while keeping the lesion unchanged. On HAM10000 and dark-skin ISIC images, CAMEO maintained accuracy while reducing background-driven errors by nearly four times. It also made the model's attention more consistent when backgrounds changed. Results across multiple tests show that reducing reliance on background information improves robustness, with Fitzpatrick-based backgrounds providing a realistic and interpretable approach. Results show that XAI-guided augmentation can make dermoscopic classifiers measurably more robust and fair at no cost to accuracy. They also clarify that it is the mechanism and not the specific tone palette that matters, and that the lasting contribution of XAI here lies in stability-screened, annotation-free lesion localisation rather than in the robustness number itself.
https://arxiv.org/abs/2609.36400
Deep learning models have achieved strong performance in artificial intelligence for science, yet their black-box nature limits our understanding of how they learn scientific tasks. Existing methods for interpretability provide limited insight into how models organize evidence and evolve during learning. We introduce explainability from training (EFT), a model-agnostic paradigm that traces model interpretation during training to explain why models rely on specific features and how they organize these features as predictive evidence. We apply EFT to four state-of-the-art T cell receptor (TCR)-epitope prediction models, TCR-SRIM, TULIP, MixTCRpred, and NetTCR-2.2, spanning post-hoc and interpret-by-design approaches as well as transformers and CNNs. To investigate how structural information affects model explanations, we introduce a benchmark, TCR-XAI2, containing 388 unique experimentally resolved TCR-epitope structures, complemented by structures predicted using AlphaFold3, Boltz-2, TCRModel2, tFold-TCR, and OpenFold3. Using EFT with TCR-XAI2, we demonstrate that (1) CNN and transformer models exhibit distinct learning trajectories; (2) TCR $\alpha$ and $\beta$ evidence can conflict during learning, limiting the benefits of jointly modeling both chains, while MHC information mitigates this; and (3) real versus predicted structural data for TCR-epitope prediction exhibits distinct TCR and peptide feature preferences as well as differing trajectories of model certainty.
https://arxiv.org/abs/2609.36354
Figuring out how objects relate to each other, like whether they touch, overlap, stay completely separate or one sits inside another, matters a lot in fields like GIS, biomedical imaging, and robotics. Even though machine learning has come a long way, people haven't really focused on spotting these topological relationships in images. The main roadblocks? Not enough good datasets and no clear way to measure results. So, we rolled up our sleeves and built a new dataset. It's pretty sizable: over 11,000 labelled images showing all those essential relationships. We ran tests with some classic machine learning models, Naive Bayes, KNN, Random Forest, SVM, and Artificial Neural Networks, and threw in some deep learning stars like VGG16 and InceptionResNetV2. For the dataset itself, we used segmentation, contour detection, and grayscale normalization to tease out solid feature vectors. The results? Deep learning methods, especially VGG16, pulled ahead, with validation accuracy hitting 89.55%. That's a big jump compared to the traditional models. This shows how powerful transfer learning is for analyzing topological relationships in images, and it gives researchers a new standard to aim for in future work on spatial reasoning and topological classification.
https://arxiv.org/abs/2609.36172
Infant movement analysis provides valuable biomarkers for the early identification of neurodevelopmental disorders. Recent advances in deep learning have enabled automated analysis of infant movements from video-derived skeletal representations, achieving performance comparable to expert assessment for tasks such as General Movement Assessment (GMA). However, most existing approaches rely on centralized training, requiring data from multiple institutions to be collected and stored at a single site. Such assumptions are often impractical in clinical settings due to privacy, governance, and data-sharing constraints. To address these challenges, we present, to the best of our knowledge, the first federated learning framework for automated infant movement analysis and General Movement Assessment using skeletal motion data. As a clinically relevant use case, the proposed framework is evaluated on fidgety movement classification. To quantify model confidence, Monte Carlo (MC) Dropout is employed to estimate predictive uncertainty during inference. Building upon this, we propose an Uncertainty-Aware Federated Averaging (UA-FedAvg) strategy that incorporates predictive entropy derived from MC-Dropout into the federated aggregation process, enabling client contributions to be adjusted according to their predictive uncertainty. Experiments were conducted using a cross-subject evaluation protocol under a three-client federated learning setting. Results demonstrate that federated learning substantially improves classification performance compared with independently trained local models while achieving performance approaching that of centralized training. Furthermore, UA-FedAvg and its variant incorporating validation loss generally outperform conventional FedAvg across the evaluated data-split configurations.
https://arxiv.org/abs/2609.31463
Cloth manipulation is a challenging task due to the deformable and high-dimensional nature of cloth, which leads to complex interaction dynamics and perceptual ambiguity arising from frequent occlusions of critical visual cues such as folds, edges, and grasp points. In this work, we tackle cloth unfolding using a regrasping-in-the-air strategy, where one manipulator holds the cloth while the other grasps it at an optimally selected point to unfold it. To this end, we propose CeDiRNet-6DoF, a deep learning framework that jointly predicts effective grasp points and the complete 6-DoF grasp pose from the observed cloth configuration. By integrating dense 3D grasp regression with segmentation and sine-cosine-encoded Euler angles, the proposed method reliably estimates the grasp configuration that maximizes the unfolded cloth area. We extensively evaluated CeDiRNet-6DoF on a bimanual robotic setup within the ICRA 2024 Cloth Competition framework, achieving state-of-the-art performance. An ablation study further validates the benefits of key design components, including joint segmentation, background randomization, and image cropping. These results establish CeDiRNet-6DoF as a robust and versatile foundation for reliable robotic cloth manipulation in unstructured environments.
https://arxiv.org/abs/2609.31452
Auditory Attention Detection (AAD) utilizes electroencephalographic (EEG) signals to identify a target speaker in a multi-speaker environment. Despite considerable progress, existing deep learning architectures often lack explicit mechanisms for handling noisy EEG data. To address this limitation, we propose Auditory Focus Attention Networks (AFA-Net), a machine learning framework that replaces vanilla attention with a simple yet flexible differential attention mechanism to help focus on task-relevant neural activity. AFA-Net achieves an upward accuracy of 96.8% at the 2s decision window, while using substantially fewer parameters than most existing methods. To the best of our knowledge, AFA-Net is among the first frameworks to explicitly try to combat EEG noise to improve AAD.
https://arxiv.org/abs/2609.31402
Vessel segmentation in medical images is essential for many clinical tasks, ranging from diagnosis to treatment planning. However, it remains challenging due to complex vascular morphology and diverse imaging conditions. Existing deep learning methods rarely aim at building a generalizable vessel segmentor across anatomies and modalities. While the Seg- ment Anything Model (SAM) has shown promise for med- ical image segmentation, its original design does not fully exploit vascular morphology and struggles with fine-grained vascular structures, leading to suboptimal performance. In this paper, we propose ReG-SAM, a SAM-based framework tailored to 2D vessel segmentation that leverages reference graph set for enhancing vascular representations. Specifically, we introduce two modality-aware representations derived from the reference masks: graph prompt embeddings (GPEs) that encode global spatial features from graphs, and vascu- lar prototype embeddings (VPEs) that capture fine-grained modality-specific vessel characteristics from multi-scale fea- ture maps and vascular masks. Since both require vascular masks that are unavailable during inference and require robust modality-aware vascular feature representations, we construct a modality-wise vascular database and develop two reference graph-guided representation learning schemes for estimating GPEs and VPEs using samples from the database rather than ground-truth masks. Extensive experiments across 19 datasets demonstrate that ReG-SAM consistently outperforms existing baselines, even those using manual prompts, particularly on challenging thin vessels.
https://arxiv.org/abs/2609.31160
Semantic communication (SemCom) and integrated sensing and communication (ISAC) are promising technologies for future 6G wireless networks. Existing studies have applied semantic technology to either the communication module or the sensing module of ISAC. In this work, we propose SemISAC, which performs both SemCom and semantic sensing within a single dual-function waveform. SemISAC uses a joint semantic encoder that extracts task-specific information for both communication and sensing. We evaluate SemISAC in a vehicular scenario in which vehicles share pixel-wise segmentation of the road environment and, through sensing, classify surrounding objects and estimate their ranges. On the transmitter side, a deep learning encoder converts the input road-scene image into semantic symbols and places them on the data cells of an OFDM grid, while the remaining cells serve as pilots for channel state information estimation and sensing. The pilot configuration is adaptively optimized based on the channel conditions to balance communication and sensing requirements. At the receiver, a deep learning model reconstructs the segmentation from the received waveform, while the transmitting vehicle captures the reflected waveforms from surrounding objects and uses task-specific deep learning decoders for target recognition and range estimation. Simulation results show that SemISAC achieves a segmentation accuracy close to that of the dedicated SemCom module while outperforming both conventional and semantic baselines in target recognition and range estimation.
https://arxiv.org/abs/2609.30891