The categorization of cognitive and resting states derived from electroencephalography (EEG) signals is crucial for comprehending fluctuations in brain activity linked to various mental states. EEG provides a non-intrusive approach for documenting brain function in both resting and task-oriented cognitive conditions, whilst deep learning techniques enable the automatic extraction of significant patterns from intricate EEG data. This study presents a deep learning framework to distinguish between resting and cognitive states through EEG records. The proposed framework integrates a Convolutional Neural Network (CNN) stacked with a Gated Recurrent Unit (GRU) for the extraction of features from EEG signals. Time-frequency analysis is conducted to explore the salient aspects of signals, and the derived features are then assessed utilizing conventional deep learning and machine learning classifiers, including the suggested 2D-Net architecture. The proposed approach and feature extraction strategy outperform the evaluated comparative methods, achieving accuracies of 83.177% for resting-versus-mathematical task classification, 76.107% for resting-versus-memory task classification, and 83.432% for resting-versus-music task classification. The findings illustrate the efficacy of integrating signal processing with deep learning methodologies to discriminate resting from cognitive states utilizing EEG signals.
https://arxiv.org/abs/2609.20467
Objectives: Quantitative assessment of infarct hypodensity on non-contrast computed tomography (NCCT), including net water uptake (NWU), requires manual or semi-manual lesion delineation, often guided by CT perfusion or diffusion-weighted MRI, limiting clinical applicability. Automated segmentation on NCCT could enable efficient biomarker extraction such as NWU but remains challenging across heterogeneous multicenter data. This study aimed to develop and externally test a domain-aware deep learning framework for ischemic stroke segmentation on NCCT and assess its suitability for NWU quantification. Materials & Methods: In this retrospective multicenter study of 801 patients from four datasets, an nnU-Net-based model was trained on NCCT scans from the University Medical Center Hamburg-Eppendorf and the Acute Ischemic Stroke Dataset. To adapt to new domains, the model was fine-tuned on target-domain subsets from Boston (n=11) and ISLES (n=75), with evaluation on held-out cases not used for fine-tuning. Automated segmentations and NWU values were compared with expert references. Results: For lesions $\geq$ 30 mL, median Dice was 0.68 (Boston) and 0.56 (ISLES). Including smaller lesions, which predominated in ISLES, median Dice was 0.54 (interquartile range [IQR] 0.30-0.70) for acute lesion segmentation (Boston dataset) and 0.20 (IQR 0.03-0.41) for NCCT lesion segmentations when compared to post-treatment infarct (primary target of the ISLES challenge). Automated NWU mean absolute error was 1.37 percentage points (SD 1.61, Boston). Conclusion: Target-domain adaptation supported NCCT-only infarct segmentation across heterogeneous external cohorts, although performance varied across domains. The approach enabled low-error NWU quantification from baseline NCCT without advanced imaging, supporting further prospective clinical evaluation.
https://arxiv.org/abs/2609.20151
Deep learning models for multi-modal breast cancer diagnosis achieve high predictive accuracy but remain clinically unacceptable without actionable, counterfactual explanations. Attribution-based methods (LIME, SHAP) are categorically inapplicable to this purpose, as they generate no alternative instances and thus cannot be evaluated on counterfactual quality metrics. This investigation provides empirical evidence that FCA-Guided Counterfactual (FCA-CF) framework that uses a Formal Concept Analysis (FCA) concept lattice as a hard structural constraint on counterfactual search, operating over a multi-modal TCGA-BRCA dataset. We benchmark against four genuine counterfactual methods: Wachter-style CF, DiCE, FACE, and NICE, evaluated on 60 benign-predicted TCGA-BRCA instances. The FCA-CF framework achieves Validity = 1.0000 (100% of counterfactuals successfully flip the prediction), Sparsity = 2.37 features changed (best among all valid methods), and Proximity = 0.900 (normalised L2-based, matching NICE as joint best). The classifier achieves Accuracy = 0.980, F1 = 0.976, ROC-AUC = 0.9947. Ablation analysis confirms that the FCA lattice constraint is the primary sparsity driver (removing it increases sparsity by +40%, p < 0.001, Cohen's d = 0.78), while Phase C greedy refinement accounts for the largest individual contribution (+113% sparsity increase when disabled, p < 0.001, d = 5.01). FCA-guided counterfactual generation achieves a clinically important Pareto-dominant outcome; it is simultaneously the sparsest and among the most proximate of all valid methods, with perfect validity. The emergent sparsity property arising from lattice topology rather than numerical penalty terms constitutes a structurally novel contribution to the counterfactual explanation literature.
https://arxiv.org/abs/2609.20067
Time series forecasting has seen signicant advancements with the emergence of new deep learning models. However, forecasting time series in applications involving physical processes remains a major challenge. Despite the apparition of Physics Informed Neural Networks (PINN), recent models do not estimate unobservable intermediate physical variables, which are important for domain experts to understand the target behavior. To this end, we propose a Physics Informed Recurrent Neural Network (PIRNN) which predicts, along the target, unobservable variables on both historic data and forecast target. This approach enhances the model robustness and results interpretation using domain knowledge. Our method is easily adaptable to any physical model using several equations, each having its own set of unobservable variables, to describe it-self. As a case study, we incorporate physical equations used for groundwater levels predictions by the physical model called Gardenia. This model uses transfers equations between reservoirs, optimized with data assimilation, to simulate the evolution of groundwater levels. Evaluation includes several well known neural network models and the Gardenia model compared on twelve real world datasets. In addition, we study the impact of each component through an ablation study. Our model outperforms other models on ve out of the twelve datasets and our ablation study underlines the importance of having a physical background in our time series forecasting task. Finally, the coherence of the physical variables predicted by our neural network is assessed by a domain expert.
https://arxiv.org/abs/2609.19871
Accurate classification of brain disorders from neuroimaging data remains challenging because of substantial inter-subject heterogeneity and the complex multi-scale patterns present in functional connectivity and morphological representations. To address these challenges, we propose HyperAMS-Net, a deep learning framework for brain disorder classification using neuroimaging representations derived from resting-state functional MRI or structural MRI. HyperAMS-Net integrates adaptive multi-scale convolution, hypergraph attention, spatial-channel attention, and adaptive feature fusion. Specifically, adaptive multi-scale convolution learns data-driven weights over multiple receptive fields to capture complementary patterns at different scales. Hypergraph attention models higher-order dependencies among learned feature representations through node--hyperedge--node message passing, while spatial-channel attention enhances discriminative feature learning. Adaptive feature fusion further aggregates complementary information across parallel network branches. HyperAMS-Net is evaluated on three benchmark datasets spanning distinct brain disorders: ABIDE for autism spectrum disorder, REST-meta-MDD for major depressive disorder, and ADNI for Alzheimer's disease, using 5-fold stratified cross-validation. HyperAMS-Net achieves state-of-the-art performance across all evaluated datasets, attaining the highest accuracy and AUC among the compared methods. Ablation studies further demonstrate the contribution of each proposed component, with the largest performance degradation observed when hypergraph attention is removed.
https://arxiv.org/abs/2609.19755
Recent innovations in deep learning have significantly enhanced the diagnosis of medical images, although they are based on the use of centralized data storage that pose severe threats to patient privacy and medical data security. To address this issue, this research proposes a Federated Learning (FL) model that is coupled with an optimized YOLOv8 network to detect the kidney stones on a computed tomography (CT) image and at the same time, protect privacy of the patients. The suggested system can help various medical organizations to jointly train a common model without exchanging the information about the patients. This is to ensure that data protection laws like GDPR and HIPAA are adhered to. The residual feature fusion and DropBlock regularization among other architectural improvements are also included in YOLOv8 to enhance detection robustness and minimize overfitting. Experimental analysis carried out on a distributed CT dataset demonstrated that the federated YOLOv8 model has a mAP at 50 of 0.733 and is able to keep the data confidential. Moreover, its lean design facilitates fast edge deployment and real-time inference across a clinical setting. Altogether, these findings indicate that Federated Learning is a safe and efficient solution to AI-assisted diagnosis in contemporary healthcare when combined with the use of sophisticated object detection models.
https://arxiv.org/abs/2609.19740
Accurate estimation of left ventricular ejection fraction (EF) from echocardiography is central to cardiovascular care, and deep learning enables automated EF prediction from echocardiographic video. Because EF is clinically derived from left-ventricular (LV) volumes, a widely held intuition is that explicit LV segmentation should improve prediction. We introduce a quantitative criterion, the segmentation ceiling, that makes this testable: from EF as a normalized difference of end-diastolic and end-systolic volumes, we derive in closed form how per-frame segmentation area error propagates into EF error, and thus the accuracy a mask must reach before it can improve on direct regression. Using EchoNet-Dynamic, a UniFormer-S backbone, and the empirically measured within-patient error correlation, the criterion places the break-even near 10% per-frame area error, whereas a representative segmenter operates at roughly 14%, above the ceiling. Consistent with this, four strategies for injecting segmentation or area information (a predicted-mask channel, end-diastolic/end-systolic clip sampling, and per-bin and amplitude area-consistency objectives) fail to beat a raw-video baseline; ground-truth masks help only through label leakage. Input representation thus not being the limit, we identify generalization as the practical lever: weight averaging with strong augmentation attains a test R^2 of 0.806 (MAE 4.08) under a matched dense-clip protocol, comparable to an R(2+1)D baseline (0.811) while tightening the validation-to-test gap. Finally, a heteroscedastic beta-NLL formulation yields informative, well-calibrated per-prediction uncertainty, larger for clinically harder low-EF cases, where Monte-Carlo dropout does not. The segmentation ceiling gives a concrete design criterion for when mask-guided EF estimation is worthwhile, plus a simple, uncertainty-aware recipe for EF regression.
https://arxiv.org/abs/2609.19730
This study developed and evaluated a deep-learning-based perception framework for selective robotic cotton picking. The dataset contained 1,008 annotated field images collected using three cameras under varying natural lighting and weather conditions. Object-detection models from the YOLOv8 through YOLOv13 families were evaluated using their default configurations, while segmentation performance was assessed using YOLOv8-seg, YOLOv11-seg, YOLOv12-seg, the Segment Anything Model (SAM), SAMv2.1, FastSAM, and Grounded-SAM with the Recognize Anything Model (RAM). Among the detection models, GELAN-s achieved the most favorable balance between mean average precision (mAP) and inference speed, obtaining an mAP of 86.1%, precision of 81.6%, recall of 76.6%, and an F1-score of 79.0%, with an average inference time of 42.3 ms per image. Among the direct segmentation models, YOLOv12-m-seg provided the most favorable balance between AP@0.5 and FPS, achieving a segmentation AP@0.5 of 83.7% with an inference time of 20.4 ms per image. In the detection-prompted segmentation approach, bounding-box prompts generated by GELAN-s improved the localization of cotton bolls for SAM and SAMv2.1, while SAMv2.1 Tiny consistently outperformed FastSAM and Grounded-SAM with RAM. In the area-based evaluation against manually annotated segmentation masks, YOLOv12-m-seg achieved an $R^2$ value of 0.966, compared with 0.860 for GELAN-s + SAMv2.1 Tiny. Field experiments conducted using a UR5e robotic manipulator, a custom end-effector, and a ZED2i stereo camera further validated the effectiveness of the YOLOv12-m-seg model for real-time cotton boll detection, segmentation, and selective picking under varying confidence levels. These results demonstrate that YOLOv12-m-seg provides an efficient perception model for robotic cotton harvesting and has strong potential for field deployment.
https://arxiv.org/abs/2609.19592
Scaling deep learning faces critical bottlenecks: data exhaustion, exponential training costs, and resource concentration. Model merging combines pre-trained checkpoints without gradient descent, offering orders-of-magnitude savings versus retraining. Combining independently trained vision models is difficult when their architectures and parameter shapes differ. Existing weight-space merging methods generally assume aligned, shape-compatible checkpoints, whereas a Vision Transformer (ViT) and a state-space model (SSM) implement token mixing with different operators. We study a hybrid Heterogeneous merging setting that retains both architectures while aligning parameter groups by semantic role. Our proposed Riemannian--Lorentz Parameter Fusion (RLPF) method projects aligned groups to common coordinates, lifts selected coordinates to the Lorentz hyperboloid model of hyperbolic space, computes a regularized geodesic barycenter, and decodes the result into the two branches. A learned gate then combines branch logits for each input. Component groups use fixed curvature values, with normalization parameters treated as Euclidean. In the results available in this manuscript, the fine-tuned system obtains 82.37\% on CIFAR-10, 75.04\% on Oxford-IIIT Pet, and 78.58\% top-1 accuracy on ImageNet-1K; the corresponding best-parent accuracies are 76.54\%, 71.42\%, and 76.42\%. On ImageNet-1K, the reported pre-fine-tuning initialization reaches 77.80\%. These results support further study of geometry-aware heterogeneous fusion, but not a training-free single-checkpoint merge: RLPF is a two-branch hybrid whose gate and reported final models are trained.
https://arxiv.org/abs/2609.19384
Clinical decision-making for coronary intervention relies mainly on angiography and fractional flow reserve (FFR). However, angiography is two-dimensional and lacks depth information for 3D lesion characterization, while FFR provides only a single functional index, offering limited hemodynamic insight. Among existing methods, numerical analysis is computationally expensive, whereas learning-based approaches require extensive supervision and often lack physical consistency. To address these limitations, we propose physics-informed hemodynamic modeling, an integrated deep learning framework for 3D coronary blood flow analysis from dual-view angiography. First, an attention-enhanced CNN reconstructs coronary geometry from angiography. The resulting point clouds are then mapped to a reference domain and Fourier-encoded for joint representation. A decoupled network separately predicts velocity and pressure fields, with embedded physical priors enabling efficient transfer across physiological conditions. Across 32 clinical patients evaluated under four flow conditions, the trans-stenotic pressure-drop mean absolute percentage error was 2.02%, while the velocity and pressure relative-L2 errors were 0.054 and 0.023, respectively. Validation against hospital-measured FFR further achieved 93.8% diagnostic accuracy (30/32; exact 95% CI, 79.2%-99.2%). The framework also supports illustrative revascularization comparisons and sparse-data assimilation, with the full angiography-to-hemodynamics pipeline completed within 20 minutes per patient.
https://arxiv.org/abs/2609.19290
Long-range infrared imaging frequently confronts dense target clusters whose diffraction-limited signatures merge into a single indistinguishable blob, concealing the number, sub-pixel positions, and radiant intensities of the underlying sources. While deep learning has advanced general object detection, resolving such Closely-Spaced Infrared Small Targets (CSIST) remains largely unexplored, owing to a systemic infrastructure void and a fundamental paradigm mismatch. The dominant formulation, which reduces unmixing to a blind, discrete sub-pixel separation, is inherently insufficient: without semantic guidance, the ill-posed inverse problem admits ambiguous solutions plagued by false and missed detections, while grid-based discretization locks predictions onto fixed lattice centers, chaining precision to prohibitively expensive grid refinement. We argue that CSIST unmixing should instead be informed and continuous. To ground this paradigm shift, we establish the first comprehensive open-source ecosystem for the field, comprising the large-scale CSIST-100K benchmark, a tailored metric suite, and the GrokCSO toolkit. Upon this foundation, we propose DISTA-Net++, which anchors a dynamic deep unfolding backbone with two synergistic mechanisms: a Count-Guided Prior that injects the global target count as an explicit semantic constraint to regularize the solution space, and a Continuous Coordinate Rectification that regresses off-grid offsets to decouple localization accuracy from grid resolution. Extensive experiments validate our paradigm: even under the most economical 3x division, DISTA-Net++ surpasses 7x-division state-of-the-art methods by 16.15% in CSO-mAP and 62.96% in count accuracy at merely one-sixth of their computation, demonstrating that unmixing precision need not be purchased with finer discretization. The complete ecosystem is available at this https URL.
https://arxiv.org/abs/2609.18773
Wildfire spread is traditionally predicted using physics-based simulators, which are physically interpretable but whose cost increases with each additional ensemble member. We ask how well deep learning surrogates can reproduce these simulations at a fraction of this cost, training them on 10,584 fire spread simulations at 2m resolution for the Rectoret region in Catalonia, Spain. Four architectures are compared: a patch-based U-Net, a transfer-learned ResNet-50, a physics-informed network constrained by the wind-driven advection equation and a Swin-Unet transformer. Among the terrain and vegetation variables, only surface fuel load predicts burn probability with any strength (r = 0.27) and including it lowers prediction error by 21%. The remaining variables correlate weakly and are highly duplicative. Next, an experiment with saliency, occlusion and rotation demonstrates the models' learning. Convolutional models rely primarily on distance from the current fire front, while Swin-Unet assigns more weight to fuel and terrain, a finding also noted in an unrelated wildfire dataset. When applied without retraining to the second region, Pedriza, all three convolutional models still predict fire spread, losing accuracy by a small but systematic margin.
https://arxiv.org/abs/2609.18555
The world population is growing rapidly, and technology is improving in parallel. Meeting the huge demand for food for these 7 billion people not only depends on increasing food production but also on reducing food loss. Crop losses due to disease affect both the food supply and the financial and economic stability of a country. Tomatoes are among the top food-producing crops globally, and a significant portion of this production is lost due to disease. People have used Machine Learning techniques for feature extraction and early diagnosis of tomato diseases, and nowadays, Deep Learning-based models are widely used for disease recognition. However, most existing models are highly parameter-intensive, which increases the time required for training and inference. As a result, while lightweight models are more suitable for user-friendly applications, they often show a reduction in performance. To balance performance and model size, we propose CoAtNet-DeepMoE, a Convolution-Attention hybrid architecture for rich feature extraction, further enhanced with a DeepSeek Mixture of Experts to substantially reduce the number of parameters without sacrificing accuracy. We evaluate our model on both balanced and imbalanced datasets from Kaggle and PlantVillage, demonstrating robustness and achieving 99.80% accuracy, 99.80% precision, 99.80% recall, and 99.80% F1-score on Kaggle, and 99.83% accuracy, 99.85% precision, 99.76% recall, and 99.80% F1-score on PlantVillage, representing state-of-the-art performance with only 2.47M parameters. The source code will be available at this https URL.
https://arxiv.org/abs/2609.18038
Large trees disproportionately contribute to biomass storage, habitat structure, and ecosystem functioning. However, their distribution and health dynamics remain poorly quantified at a regional scale. Here, a deep learning model (U-Net-ID) and canopy height models derived from sub-meter aerial imagery from 2020 were used to delineate all individual trees with crown area $\geq$ 100 m$^2$ across the Sierra Nevada Floristic Province. The model was trained using more than 3.3 million synthetic tree crowns and achieved a median Intersection over Union (IoU) of 0.602 when validated against an independent dataset of 20,273 crowns. A total of 6,515,705 large trees were mapped, occurring across approximately 78.7% of the Sierra Nevada Floristic Province. The spatial distribution of large trees showed associations with elevation, temperature, and precipitation. Using Sentinel-2 time series from 2020 to 2025, tree health dynamics were characterized by extracting spectral trajectories for each crown and applying BFAST breakpoint detection algorithm combined with a disturbance classification framework to identify mortality, disturbance, and recovery trajectories of individual trees. Wildfires, estimated from CAL FIRE fire perimeters, were identified as the dominant driver of large-tree mortality, killing 10% of all large trees in the Sierra Nevada, with mortality strongly concentrated during the extreme 2020-2021 fire seasons.
https://arxiv.org/abs/2609.17925
No-reference video quality assessment (NR VQA) has recently seen promising progress with deep learning. However, video data is inherently large, and processing them with deep models incurs high computational cost. This challenge is particularly acute in VQA, where preserving original-resolution cues and dense temporal information is critical for accuracy. Existing efficiency-driven preprocessing strategies, such as fragmenting, reduce computation but alter the input data distribution, limiting effective reuse of pretrained video foundation models (ViFMs). To address these challenges, we propose \textbf{H}igh-\textbf{F}idelity \textbf{V}ideo \textbf{Q}uality \textbf{A}ssessment (\textbf{HFVQA}), a framework built on fixed-size spatio-temporal (ST) patches that is fully compatible with pretrained ViFMs. HFVQA samples ST patches across multiple scales, including the original resolution, with minimal temporal subsampling to preserve low-level quality cues and semantic context. To limit computation, HFVQA introduces a lightweight auxiliary network trained end-to-end with the ViFM encoder to learn \textit{VQA-specific saliency}. Distilled directly from quality supervision, this saliency captures task-specific importance patterns, reflecting that video quality perception is dominated by a small subset of spatio-temporal regions. By combining high-fidelity spatio-temporal cues with learned, task-specific saliency, HFVQA achieves SOTA performance on standard NR VQA benchmarks while processing as little as 12\% of candidate ST patches, making high-fidelity ViFM-based VQA computationally tractable.
https://arxiv.org/abs/2609.16946
Pedestrian-count forecasting supports pedestrian-oriented Intelligent Transportation Systems (ITS), including crowd monitoring, pedestrian-traffic staffing and routing, and proactive risk mitigation during surges. Recent time-series foundation models (FMs) report strong zero-shot accuracy on heterogeneous forecasting benchmarks, but it remains unclear whether these gains transfer reliably to pedestrian sensing deployments. We benchmark seven univariate forecasting approaches spanning four paradigms: Seasonal Naive, gradient-boosted trees (LightGBM, CatBoost), deep learning models (N-HiTS, PatchTST), and two pretrained FMs (TimesFM, Chronos-2). Experiments cover two complementary regimes: (i) a five-day special event dataset SAIL2025 at 3-minute resolution with limited in-domain history; and (ii) Melbourne pedestrian sensors as a multi-year hourly dataset (2010--2017) with strong seasonality. We compare the MAE and RMSE results per sensor across datasets and multiple forecast horizons. Results show three consistent findings. First, with limited historical data, Seasonal Naive remains a strong baseline for long-horizon forecasting on high-volume sensors, while trained models can degrade when the next day differs substantially from prior days. Second, boosted trees can be competitive on lower-volume sensors but exhibit higher sensitivity on high-volume sensors under event-driven shift. Third, FMs excel in the seasonal and data-rich regime under long-context configuration. The findings highlight the importance of choosing pedestrian forecasting models based on both the underlying data conditions and the forecasting horizon.
https://arxiv.org/abs/2609.16415
Existing fairness analysis tools predominantly operate as post-training evaluation frameworks, requiring practitioners to complete the full model development lifecycle before assessing bias. We present FairLint-DL, a Visual Studio Code extension that implements a shift-left approach to fairness testing by enabling pre-training, IDE-native bias detection directly on tabular datasets. FairLint-DL trains a configurable deep neural network as a proxy model and applies information-theoretic Quantitative Individual Discrimination (QID) metrics. Grounded in Shannon and min-entropy, QID quantifies the causal influence of protected attributes on predictions. The system implements a two-phase gradient-guided search algorithm for discovering discriminatory instances, a causal debugging pipeline that localizes bias to specific network layers and neurons via sensitivity analysis, and dual explainability engines using SHAP and LIME for feature-level attribution. Evaluation on three tabular benchmarks (Adult Census Income, German Credit, and Bank Marketing) reveals fairness concerns that vary widely across datasets: on Adult, 96.0% of analyzed instances exhibit QID above the 0.1-bit significance threshold, with a mean QID of 0.619 bits and a disparate impact ratio of 0.581, violating the four-fifths legal rule. FairLint-DL produces these results within 12 seconds on cached models, demonstrating the feasibility of integrating fairness analysis into the developer workflow without significant overhead.
https://arxiv.org/abs/2609.16321
Advancements in data fusion and real-time analytics technologies have opened new avenues for addressing complex domain challenges. Financial risk early warning systems often suffer from inefficiency due to information silos and monitoring delays. This paper proposes a credit risk early warning system based on heterogeneous information fusion. The system employs a model architecture integrating deep neural networks and attention mechanisms to extract multidimensional features from diverse data sources such as transaction behaviors and social networks, thereby establishing an early identification mechanism for corporate and individual credit risks. System testing demonstrates that this approach significantly enhances the accuracy and timeliness of risk warnings, outperforming traditional rule-based engine solutions. The findings offer innovative insights for early intervention in financial risks, holding practical significance for safeguarding financial stability.
https://arxiv.org/abs/2609.15744
Multimodal image registration is a key component of many clinical workflows, yet it remains challenging because corresponding anatomical structures often exhibit substantially different image intensities across modalities. In this work, we present a comprehensive benchmark of intra-patient 3D multimodal deformable registration methods across three datasets covering different anatomical regions and difficulty levels, including both synthetic deformation recovery and real clinical scenarios. We evaluate classical optimization-based approaches and modern learning-based methods, including recent deep learning and foundation models, using complementary metrics: Average Dice similarity coefficient (DSC), average 95th-percentile Hausdorff distance (HD95), and a modality-independent structural similarity measure based on the MIND self-similarity context (MIND-SSC). Results show high variability across datasets, with learning-based methods demonstrating superior performance on large synthetic benchmarks, while only limited improvements are observed in real pelvic registration. A key finding of this study is the consistent disagreement between geometric metrics (DSC, HD95) and image-based similarity metrics (MIND-SSC), highlighting that improved overlap does not necessarily imply better global multimodal correspondence. Furthermore, anatomy-guided approaches achieve the highest overlap scores but exhibit degraded performance outside of segmented regions, revealing a trade-off between label-driven alignment and global structural coherence. Overall, our results indicate that no current method achieves robust performance across anatomies and modalities. We demonstrate that intra-patient 3D multimodal registration requires multi-criteria evaluation, including deformation-based metrics, and remains an open problem.
https://arxiv.org/abs/2609.15669
This study explores the use of deep learning and explainable artificial intelligence to diagnose hepatocellular carcinoma (HCC) and define effective biomarkers across five different stages of disease development using a transcriptomic biomarker HCC dataset constructed via semi-supervised learning from three source datasets. Several deep learning experiments were conducted with different feature extraction techniques and gene sets to identify the most effective features for training high-accuracy models with minimal loss. The best-performing model, using 15 selected genes with the SelectKBest algorithm, achieved 90.74% accuracy, while the model with the lowest recorded loss of 0.3187 was obtained using 20 selected genes. To address the issue of class imbalance in the dataset, a weighted training approach was conducted, and for model transparency and interpretability a SHAP-based XAI analysis provided insights into the model's decision-making, consistently finding DNAJB14 as the most influential gene. Functional validation in this study has provided compelling evidence that DNAJB14 plays an important role in the adverse properties of HCC and that its inhibition effectively reverses tumour cell migration, invasion, colony and sphere formation. The main limitation of this study is the dataset's class imbalance, and while weighted training helped mitigate this, further research and additional data are needed to guarantee model generalizability. Future studies should also explore the influence of genetic variations, environmental factors, and clinical differences on model performance across diverse populations.
https://arxiv.org/abs/2609.15638