Abstract
Alzheimer's disease (AD) is a progressive neurological disorder associated with memory loss, cognitive decline, and behavioral disturbances. Early and accurate diagnosis is essential, yet MRI-based deep learning models often lack interpretability, limiting their clinical use. This study presents an explainable deep learning approach for four-class AD staging using 2D axial MRI images. The method combines eigenvector-based Grad-CAM with gradient smoothing to improve saliency localization and heatmap stability. Principal component analysis is applied to gradient-weighted convolutional layers, while Gaussian noise is added to saliency weights before decomposition. To address class imbalance in the Moderate Dementia category, Wasserstein Generative Adversarial Network with Gradient Penalty (WGAN-GP) generates synthetic samples to balance the four-stage training distribution. Custom convolutional neural networks are trained on the Best Alzheimer MRI Dataset, achieving 97.2% test accuracy, 97.0% balanced accuracy, and a Matthews correlation coefficient of 0.944. The area under the ROC curve ranges from 0.96 to 0.99 across classes. Generated heatmaps highlight the hippocampus and entorhinal cortex, regions associated with Alzheimer's disease biomarkers. These findings suggest that the proposed approach combines strong classification performance with improved model interpretability, although further clinical validation is needed.
Abstract (translated)
URL
https://arxiv.org/abs/2610.32374
