Accurate diagnosis of pediatric brain tumors, starting with histopathology, presents unique challenges for deep learning, including severe data scarcity, class imbalance, and fine-grained morphologic overlap across diagnostically distinct subtypes. While pathology foundation models have advanced patch-level representation learning, their effective adaptation to weakly supervised pediatric brain tumor classification under limited data remains underexplored. In this work, we introduce an expert-guided contrastive fine-tuning framework for pediatric brain tumor diagnosis from whole-slide images (WSI). Our approach integrates contrastive learning into slide-level multiple instance learning (MIL) to explicitly regularize the geometry of slide-level representations during downstream fine-tuning. We propose both a general supervised contrastive setting and an expert-guided variant that incorporates clinically informed hard negatives targeting diagnostically confusable subtypes. Through comprehensive experiments on pediatric brain tumor WSI classification under realistic low-sample and class-imbalanced conditions, we demonstrate that contrastive fine-tuning yields measurable improvements in fine-grained diagnostic distinctions. Our experimental analyses reveal complementary strengths across different contrastive strategies, with expert-guided hard negatives promoting more compact intra-class representations and improved inter-class separation. This work highlights the importance of explicitly shaping slide-level representations for robust fine-grained classification in data-scarce pediatric pathology settings.
https://arxiv.org/abs/2604.21060
The expanding ecosystem of pathology foundation models has produced powerful but fragmented tile-level representations, limiting their use in clinical tasks that require unified slide-level reasoning and interpretable linkage to clinically meaningful information. We present ASTRA, a pan-cancer framework that integrates heterogeneous foundation-model representations into a shared slide-level representation space and semantically grounds that space using structured pathology annotation fields, including classification category, cancer type, and anatomic site. ASTRA combines sparse mixture-of-experts contextualization, masked multi-model reconstruction, and contrastive alignment to structured pathology prompts to learn slide representations that support 4-category classification, 3-class solid tumor typing, 16-class cancer typing, and text-guided tumor localization without pixel-level supervision. Developed on a CHTN cohort of 10,359 whole-slide images (WSIs) spanning 16 tumor types, ASTRA consistently improves pan-cancer classification across four pathology foundation-model backbones, achieving up to 97.8% macro-AUC for 4-category classification, 99.7% for 3-class solid tumor typing, and 99.2% for 16-class cancer typing. For tumor localization, ASTRA achieves a mean Dice of 0.897 on an annotated in-domain CHTN subset (n = 380) spanning 16 cancer types and 0.738 on an external TCGA cohort (n = 1,686) spanning four cancer types. These results demonstrate that minimal structured pathology annotation fields derived from slide-level metadata can provide effective semantic supervision for unified slide representation learning, enabling both pan-cancer prediction and weakly supervised tumor localization within a single framework.
https://arxiv.org/abs/2604.22846
Clinical AI development has traditionally followed a collaborative paradigm that depends on close interaction between clinicians and specialized AI teams. This paradigm imposes a practical challenge: clinicians must repeatedly communicate and refine their requirements with AI developers before those requirements can be translated into executable model development. This iterative process is time-consuming, and even after repeated discussion, misalignment may still exist because the two sides do not fully share each other's expertise. However, autonomous coding agents may change this paradigm, raising the possibility that clinicians could develop clinical AI models independently through natural-language interaction alone. In this study, we present such an autonomous prototype for clinician-driven clinical AI development. We evaluated the system on five clinical tasks spanning dermoscopic lesion classification, melanoma-versus-nevus triage, wrist-fracture detection (including a weakly supervised variant with only 5% bounding-box annotations), and debiased pneumothorax classification on chest radiographs. Across these settings, the system consistently developed models from clinician requests and achieved promising performance. Notably, in a debiased pneumothorax classification task on chest radiographs, where chest drains can act as a major confounder, the system successfully mitigated shortcut learning and nearly halved the model's reliance on chest drains. These findings provide proof of concept that autonomous coding agents may help shift clinical AI development toward a more clinician-driven paradigm, reducing the communication overhead and dependence on specialized AI developers. Although further validation and robustness assessment are needed, this study suggests a promising path toward making clinical AI development more accessible.
https://arxiv.org/abs/2604.17110
High-resolution (HR) land-cover mapping is often constrained by the high cost of dense HR annotations. We revisit this problem from the perspective of map super-resolution, which enhances coarse low-resolution (LR) land-cover products into HR maps at the resolution of the input imagery. Existing weakly supervised methods can leverage LR labels, but they typically use them to retrain dense predictors with substantial computational cost. We propose MapSR, a prompt-driven framework that decouples supervision from model training. MapSR uses LR labels once to extract class prompts from frozen vision foundation model features through a lightweight linear probe, after which HR mapping proceeds via training-free metric inference and graph-based prediction refinement. Specifically, class prompts are estimated by aggregating high-confidence HR features identified by the linear probe, and HR predictions are obtained by cosine-similarity matching followed by graph-based propagation for spatial refinement. Experiments on the Chesapeake Bay dataset show that MapSR achieves 59.64% mIoU without any HR labels, remaining competitive with the strongest weakly supervised baseline and surpassing a fully supervised baseline. Notably, MapSR reduces trainable parameters by four orders of magnitude and shortens training time from hours to minutes, enabling scalable HR mapping under limited annotation and compute budgets. The code is available at this https URL.
https://arxiv.org/abs/2604.14582
Vision transformers (ViT) have been shown to allow for more flexible feature detection and can outperform convolutional neural network (CNN) when pre-trained on sufficient data. Due to their promising feature detection capabilities, we deployed ViTs for morphological classification of anaplastic large cell lymphoma (ALCL) versus classic Hodgkin lymphoma (cHL). We had previously designed a ViT model which was trained on a small dataset of 1,200 image patches in fully supervised training. That model achieved a diagnostic accuracy of 100% and an F1 score of 1.0 on the independent test set. Since fully supervised training is not a practical method due to lack of expertise resources in both the training and testing phases, we conducted a recent study on a modified approach to training data (weakly supervised training) and show that labeling training image patch automatically at the slide level of each whole-slide-image is a more practical solution for clinical use of Vision Transformer. Our ViT model, trained on a larger dataset of 100,000 image patches, yields evaluation metrics with significant accuracy, F1 score, and area under the curve (AUC) at 91.85%, 0.92, and 0.98, respectively. These are respectable values that qualify this ViT model, with weakly supervised training, as a suitable tool for a deep learning module in clinical model development using automated image patch extraction.
https://arxiv.org/abs/2604.13795
Semantic segmentation requires dense pixel-level annotations, which are costly and time-consuming to acquire. To address this, we present SeSAM, a framework that uses a foundational segmentation model, i.e. Segment Anything Model (SAM), with weak labels, including coarse masks, scribbles, and points. SAM, originally designed for instance-based segmentation, cannot be directly used for semantic segmentation tasks. In this work, we identify specific challenges faced by SAM and determine appropriate components to adapt it for class-based segmentation using weak labels. Specifically, SeSAM decomposes class masks into connected components, samples point prompts along object skeletons, selects SAM masks using weak-label coverage, and iteratively refines labels using pseudo-labels, enabling SAM-generated masks to be effectively used for semantic segmentation. Integrated with a semi-supervised learning framework, SeSAM balances ground-truth labels, SAM-based pseudo-labels, and high-confidence pseudo-labels, significantly improving segmentation quality. Extensive experiments across multiple benchmarks and weak annotation types show that SeSAM consistently outperforms weakly supervised baselines while substantially reducing annotation cost relative to fine supervision.
https://arxiv.org/abs/2604.11170
Semantic segmentation of 3D point cloud scenes is a crucial task for various applications. In real-world scenarios, training segmentation models often faces three concurrent forms of data insufficiency: scarcity of training scenes, scarcity of point-level annotations, and absence of 2D image sequences from which point clouds were reconstructed. Existing data-efficient algorithms typically address only one or two of these challenges, leaving the joint treatment of all three unexplored. This paper proposes a data-efficient training framework specifically designed to address the three forms of data insufficiency. Our proposed algorithm, called Point pseudo-Labeling via Open-Vocabulary Image Segmentation (PLOVIS), leverages an Open-Vocabulary Image Segmentation (OVIS) model as a pseudo label generator to compensate for the lack of training data. PLOVIS creates 2D images for pseudo-labeling directly from training 3D point clouds, eliminating the need for 2D image sequences. To mitigate the inherent noise and class imbalance in pseudo labels, we introduce a two-stage filtering of pseudo labels combined with a class-balanced memory bank for effective training. The two-stage filtering mechanism first removes low-confidence pseudo labels, then discards likely incorrect pseudo labels, thereby enhancing the quality of pseudo labels. Experiments on four benchmark datasets, i.e., ScanNet, S3DIS, Toronto3D, and Semantic3D, under realistic data-scarce conditions (a few tens of training 3D scenes, each annotated with only <100 3D points) demonstrate that PLOVIS consistently outperforms existing methods including standard fine-tuning strategies and state-of-the-art weakly supervised learning algorithms. Code will be made publicly available.
https://arxiv.org/abs/2604.11007
Modern vision-language models achieve strong performance in static perception, but remain limited in the complex spatiotemporal reasoning required for embodied, egocentric tasks. A major source of failure is their reliance on temporal priors learned from passive video data, which often leads to spatiotemporal hallucinations and poor generalization in dynamic environments. To address this, we present EgoTSR, a curriculum-based framework for learning task-oriented spatiotemporal reasoning. EgoTSR is built on the premise that embodied reasoning should evolve from explicit spatial understanding to internalized task-state assessment and finally to long-horizon planning. To support this paradigm, we construct EgoTSR-Data, a large-scale dataset comprising 46 million samples organized into three stages: Chain-of-Thought (CoT) supervision, weakly supervised tagging, and long-horizon sequences. Extensive experiments demonstrate that EgoTSR effectively eliminates chronological biases, achieving 92.4% accuracy on long-horizon logical reasoning tasks while maintaining high fine-grained perceptual precision, significantly outperforming existing open-source and closed-source state-of-the-art models.
https://arxiv.org/abs/2604.10517
High-quality Late Gadolinium Enhancement (LGE) MRI can be helpful for atrial fibrillation management, yet scan quality is frequently compromised by patient motion, irregular breathing, and suboptimal image acquisition timing. While Multiple Instance Learning (MIL) has emerged as a powerful tool for automated quality assessment under weak supervision, current state-of-the-art methods map localized visual evidence to a single, opaque global feature vector. This black box approach fails to provide actionable feedback on specific failure modes, obscuring whether a scan degrades due to motion blur, inadequate contrast, or a lack of anatomical context. In this paper, we propose Adversarial Concept-MIL (AC-MIL), a weakly supervised framework that decomposes global image quality into clinically defined radiological concepts using only volume-level supervision. To capture latent quality variations without entangling predefined concepts, our framework incorporates an unsupervised residual branch guided by an adversarial erasure mechanism to strictly prevent information leakage. Furthermore, we introduce a spatial diversity constraint that penalizes overlap between distinct concept attention maps, ensuring localized and interpretable feature extraction. Extensive experiments on a clinical dataset of atrial LGE-MRI volumes demonstrate that AC-MIL successfully opens the MIL black box, providing highly localized spatial concept maps that allow clinicians to pinpoint the specific causes of non-diagnostic scans. Crucially, our framework achieves this deep clinical transparency while maintaining highly competitive ordinal grading performance against existing baselines. Code to be released on acceptance.
https://arxiv.org/abs/2604.10303
Dense annotations, such as segmentation masks, are expensive and time-consuming to obtain, especially for 3D medical images where expert voxel-wise labeling is required. Weakly supervised approaches aim to address this limitation, but often rely on attribution-based methods that struggle to accurately capture small structures such as lung nodules. In this paper, we propose a weakly-supervised segmentation method for lung nodules by combining pretrained state-of-the-art rectified flow and predictor models in a plug-and-play manner. Our approach uses training-free guidance of a 3D rectified flow model, requiring only fine-tuning of the predictor using image-level labels and no retraining of the generative model. The proposed method produces improved-quality segmentations for two separate predictors, consistently detecting lung nodules of varying size and shapes. Experiments on LUNA16 demonstrate improvements over baseline methods, highlighting the potential of generative foundation models as tools for weakly supervised 3D medical image segmentation.
https://arxiv.org/abs/2604.08313
High-fidelity interactive digital assets are essential for embodied intelligence and robotic interaction, yet articulated objects remain challenging to reconstruct due to their complex structures and coupled geometry-motion relationships. Existing methods suffer from instability in geometry-motion joint optimization, while their generalization remains limited on complex multi-joint or out-of-distribution objects. To address these challenges, we propose GEAR, an EM-style alternating optimization framework that jointly models geometry and motion as interdependent components within a Gaussian Splatting representation. GEAR treats part segmentation as a latent variable and joint motion parameters as explicit variables, alternately refining them for improved convergence and geometric-motion consistency. To enhance part segmentation quality without sacrificing generalization, we leverage a vanilla 2D segmentation model to provide multi-view part priors, and employ a weakly supervised constraint to regularize the latent variable. Experiments on multiple benchmarks and our newly constructed dataset GEAR-Multi demonstrate that GEAR achieves state-of-the-art results in geometric reconstruction and motion parameters estimation, particularly on complex articulated objects with multiple movable parts.
https://arxiv.org/abs/2604.07728
In computational cytology, detecting malignancy on whole-slide images is difficult because malignant cells are morphologically diverse yet vanishingly rare amid a vast background of normal cells. Accurate detection of these extremely rare malignant cells remains challenging due to large class imbalance and limited annotations. Conventional weakly supervised approaches, such as multiple instance learning (MIL), often fail to generalize at the instance level, especially when the fraction of malignant cells (witness rate) is exceedingly low. In this study, we explore the use of one-class representation learning techniques for detecting malignant cells in low-witness-rate scenarios. These methods are trained exclusively on slide-negative patches, without requiring any instance-level supervision. Specifically, we evaluate two OCC approaches, DSVDD and DROC, and compare them with FS-SIL, WS-SIL, and the recent ItS2CLR method. The one-class methods learn compact representations of normality and detect deviations at test time. Experiments on a publicly available bone marrow cytomorphology dataset (TCIA) and an in-house oral cancer cytology dataset show that DSVDD achieves state-of-the-art performance in instance-level abnormality ranking, particularly in ultra-low witness-rate regimes ($\leq 1\%$) and, in some cases, even outperforming fully supervised learning, which is typically not a practical option in whole-slide cytology due to the infeasibility of exhaustive instance-level annotations. DROC is also competitive under extreme rarity, benefiting from distribution-augmented contrastive learning. These findings highlight one-class representation learning as a robust and interpretable superior choice to MIL for malignant cell detection under extreme rarity.
https://arxiv.org/abs/2604.07722
Mixture proportion estimation (MPE) aims to estimate class priors from unlabeled data. This task is a critical component in weakly supervised learning, such as PU learning, learning with label noise, and domain adaptation. Existing MPE methods rely on the \textit{irreducibility} assumption or its variant for identifiability. In this paper, we propose novel assumptions based on conditional independence (CI) given the class label, which ensure identifiability even when irreducibility does not hold. We develop method of moments estimators under these assumptions and analyze their asymptotic properties. Furthermore, we present weakly-supervised kernel tests to validate the CI assumptions, which are of independent interest in applications such as causal discovery and fairness evaluation. Empirically, we demonstrate the improved performance of our estimators compared with existing methods and that our tests successfully control both type I and type II errors.\label{key}
https://arxiv.org/abs/2604.07191
Weakly supervised semantic segmentation aims to achieve pixel-level predictions using image-level labels. Existing methods typically entangle semantic recognition and object localization, which often leads models to focus exclusively on sparse discriminative regions. Although foundation models show immense potential, many approaches still follow the tightly coupled optimization paradigm, struggling to effectively alleviate pseudo-label noise and often relying on time-consuming multi-stage retraining or unstable end-to-end joint optimization. To address the above challenges, we present ModuSeg, a training-free weakly supervised semantic segmentation framework centered on explicitly decoupling object discovery and semantic assignment. Specifically, we integrate a general mask proposer to extract geometric proposals with reliable boundaries, while leveraging semantic foundation models to construct an offline feature bank, transforming segmentation into a non-parametric feature retrieval process. Furthermore, we propose semantic boundary purification and soft-masked feature aggregation strategies to effectively mitigate boundary ambiguity and quantization errors, thereby extracting high-quality category prototypes. Extensive experiments demonstrate that the proposed decoupled architecture better preserves fine boundaries without parameter fine-tuning and achieves highly competitive performance on standard benchmark datasets. Code is available at this https URL.
https://arxiv.org/abs/2604.07021
Psychological stress is clinically relevant in cardio-oncology, yet it is typically assessed only through patient-reported outcome measures (PROMs) and is rarely integrated into continuous cardiotoxicity surveillance. We estimate perceived stress in an elderly, multicenter breast cancer cohort (CARDIOCARE) using multimodal wearable data from a smartwatch (physical activity and sleep) and a chest-worn ECG sensor. Wearable streams are transformed into heterogeneous visual representations, yielding a weakly supervised setting in which a single Perceived Stress Scale (PSS) score corresponds to many unlabeled windows. A lightweight pretrained mixture-of-experts backbone (Tiny-BioMoE) embeds each representation into 192-dimensional vectors, which are aggregated via attention-based multiple instance learning (MIL) to predict PSS at month 3 (M3) and month 6 (M6). Under leave-one-subject-out (LOSO) evaluation, predictions showed moderate agreement with questionnaire scores (M3: R^2=0.24, Pearson r=0.42, Spearman rho=0.48; M6: R^2=0.28, Pearson r=0.49, Spearman rho=0.52), with global RMSE/MAE of 6.62/6.07 at M3 and 6.13/5.54 at M6.
https://arxiv.org/abs/2604.06990
Prompt learning has gained significant attention as a parameter-efficient approach for adapting large pre-trained vision-language models to downstream tasks. However, when only partial labels are available, its performance is often limited by label ambiguity and insufficient supervisory information. To address this issue, we propose Holistic Optimal Label Selection (HopS), leveraging the generalization ability of pre-trained feature encoders through two complementary strategies. First, we design a local density-based filter that selects the top frequent labels from the nearest neighbors' candidate sets and uses the softmax scores to identify the most plausible label, capturing structural regularities in the feature space. Second, we introduce a global selection objective based on optimal transport that maps the uniform sampling distribution to the candidate label distributions across a batch. By minimizing the expected transport cost, it can determine the most likely label assignments. These two strategies work together to provide robust label selection from both local and global perspectives. Extensive experiments on eight benchmark datasets show that HopS consistently improves performance under partial supervision and outperforms all baselines. Those results highlight the merit of holistic label selection and offer a practical solution for prompt learning in weakly supervised settings.
https://arxiv.org/abs/2604.06614
Detecting unseen anomalies in unstructured environments presents a critical challenge for industrial and agricultural applications such as material recycling and weeding. Existing perception systems frequently fail to satisfy the strict operational requirements of these domains, specifically real-time processing, pixel-level segmentation precision, and robust accuracy, due to their reliance on exhaustively annotated datasets. To address these limitations, we propose a weakly supervised pipeline for object segmentation and classification using weak image-level supervision called 'Patch Aggregation for Segmentation of Targets and Anomalies' (PASTA). By comparing an observed scene with a nominal reference, PASTA identifies Target and Anomaly objects through distribution analysis in self-supervised Vision Transformer (ViT) feature spaces. Our pipeline utilizes semantic text-prompts via the Segment Anything Model 3 to guide zero-shot object segmentation. Evaluations on a custom steel scrap recycling dataset and a plant dataset demonstrate a 75.8% training time reduction of our approach to domain-specific baselines. While being domain-agnostic, our method achieves superior Target (up to 88.3% IoU) and Anomaly (up to 63.5% IoU) segmentation performance in the industrial and agricultural domain.
https://arxiv.org/abs/2604.09701
Existing hallucination detection methods for large language models (LLMs) rely on external verification at inference time, requiring gold answers, retrieval systems, or auxiliary judge models. We ask whether this external supervision can instead be distilled into the model's own representations during training, enabling hallucination detection from internal activations alone at inference time. We introduce a weak supervision framework that combines three complementary grounding signals: substring matching, sentence embedding similarity, and an LLM as a judge verdict to label generated responses as grounded or hallucinated without human annotation. Using this framework, we construct a 15000-sample dataset from SQuAD v2 (10500 train/development samples and a separate 5000-sample test set), where each example pairs a LLaMA-2-7B generated answer with its full per-layer hidden states and structured hallucination labels. We then train five probing classifiers: ProbeMLP (M0), LayerWiseMLP (M1), CrossLayerTransformer (M2), HierarchicalTransformer (M3), and CrossLayerAttentionTransformerV2 (M4), directly on these hidden states, treating external grounding signals as training-time supervision only. Our central hypothesis is that hallucination detection signals can be distilled into transformer representations, enabling internal detection without any external verification at inference time. Results support this hypothesis. Transformer-based probes achieve the strongest discrimination, with M2 performing best on 5-fold average AUC/F1, and M3 performing best on both single-fold validation and held-out test evaluation. We also benchmark inference efficiency: probe latency ranges from 0.15 to 5.62 ms (batched) and 1.55 to 6.66 ms (single sample), while end-to-end generation plus probe throughput remains approximately 0.231 queries per second, indicating negligible practical overhead.
https://arxiv.org/abs/2604.06277
Task-driven features learned by modern object detectors optimize end task loss yet often capture shortcut correlations that fail to reflect underlying annotation structure. Such representations limit transfer, interpretability, and robustness when task definitions change or supervision becomes sparse. This paper introduces an annotation-guided feature augmentation framework that injects embeddings into an object detection backbone. The method constructs dense spatial feature grids from annotation-guided latent spaces and fuses them with feature pyramid representations to influence region proposal and detection heads. Experiments across wildlife and remote sensing datasets evaluate classification, localization, and data efficiency under multiple supervision regimes. Results show consistent improvements in object focus, reduced background sensitivity, and stronger generalization to unseen or weakly supervised tasks. The findings demonstrate that aligning features with annotation geometry yields more meaningful representations than purely task optimized features.
https://arxiv.org/abs/2604.03839
Learning methods using synthetic data have attracted attention as an effective approach for increasing the diversity of training data while reducing collection costs, thereby improving the robustness of model discrimination. However, many existing methods improve robustness only indirectly through the diversification of training samples and do not explicitly teach the model which regions in the input space truly contribute to discrimination; consequently, the model may learn spurious correlations caused by synthesis biases and artifacts. Motivated by this limitation, this paper proposes a learning framework that uses provenance information obtained during the training data synthesis process, indicating whether each region in the input space originates from the target object, as an auxiliary supervisory signal to promote the acquisition of representations focused on target regions. Specifically, input gradients are decomposed based on information about target and non-target regions during synthesis, and input gradient guidance is introduced to suppress gradients over non-target regions. This suppresses the model's reliance on non-target regions and directly promotes the learning of discriminative representations for target regions. Experiments demonstrate the effectiveness and generality of the proposed method across multiple tasks and modalities, including weakly supervised object localization, spatio-temporal action localization, and image classification.
基于合成数据的学习方法因其能有效提升训练数据多样性、降低采集成本,进而增强模型判别鲁棒性而受到关注。然而,现有方法大多仅通过训练样本多样化间接提升鲁棒性,并未明确指导模型识别输入空间中真正贡献判别能力的区域;因此模型可能习得由合成偏差与伪影导致的虚假关联。针对这一局限,本文提出一种利用训练数据合成过程中获取的溯源信息作为辅助监督信号的学习框架,该信息指示输入空间中各区域是否源自目标对象,从而促进模型聚焦于目标区域的表征学习。具体而言,在合成过程中基于目标与非目标区域的信息对输入梯度进行分解,并引入输入梯度引导机制以抑制非目标区域的梯度响应。该方法可抑制模型对非目标区域的依赖,并直接促进目标区域判别性表征的学习。实验表明,所提方法在弱监督目标定位、时空动作定位及图像分类等多个任务与模态中均具有有效性与通用性。
https://arxiv.org/abs/2604.02946