Medical
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ProtoCAM: Interpretable Few-Shot Mask-Guided Prototypical Learning for Breast Lesion Classification in Ultrasound Imaging
2026-09-11 12:05:39Ashkan EbadiAbstract
Breast ultrasound imaging plays an important role in the early detection and diagnosis of breast cancer, particularly for patients with dense breast tissue. However, developing reliable deep learning models for ultrasound analysis is challenging due to limited annotated medical data and the need for interpretable predictions. To address these challenges, this paper proposes ProtoCAM, an explainable few-shot learning framework for breast lesion classification that integrates mask-guided feature encoding, prototypical metric learning, and gradient-based visual explanations. The proposed approach leverages lesion masks to guide feature extraction and constructs class prototypes within an embedding space to enable robust classification under limited training samples. The framework was evaluated on the BUSI dataset using a stratified group k-fold cross-validation protocol to prevent patient-level data leakage. Experimental results demonstrate ProtoCAM's high performance in low-data scenarios. In a 3-way 5-shot setting, the proposed method achieves a macro F1-score of 0.910, representing a substantial improvement over standard supervised CNN models. Among the evaluated backbone networks, ResNet18 achieved the best performance, reaching a macro F1-score of 91.65% under a 15-shot configuration, providing interpretable insights into the classification decisions. These results highlight the potential of explainable few-shot learning frameworks for reliable computer-aided breast cancer diagnosis in data-scarce medical imaging environments.
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https://arxiv.org/abs/2609.13340
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Automated Distinction of Intimal and Medial Intracranial Arterial Calcification from CT Head
2026-09-11 10:19:06Benjamin Jin, Maria del C. Vald\'es Hern\'andez, Richard Bortsov, Joanna M. Wardlaw, Daniel Bos, Grant MairAbstract
Intracranial arterial calcifications (IACs) are a common finding on clinical non-contrast enhanced head CT scans and are associated with neurovascular disease. Calcifications can occur in the intimal or medial layer of the arterial wall, subtypes that differ in aetiology and may have distinct clinical relevance. These subtypes can be visually distinguished by radiologists based on the shape of the calcifications. We investigate three automated approaches for subtype classification of IAC from head CT-derived segmentation masks: (1) an automated adaptation of the established radiological visual score, (2) a sphericity-based method, and (3) a method based on shape embeddings extracted by a medical shape foundation model. All approaches use the same lightweight classification pipeline on top of the features they compute and are evaluated using 5-fold cross-validation. The three methods achieved comparable performance, with the embedding-based approach yielding the best overall results with a weighted F1 (mean $\pm$ SD) of up to 71.5 $\pm$ 3.7 for a single artery and 59.8 $\pm$ 1.7 for the joint artery classification. Performance was largely preserved when using automated instead of manual IAC segmentation masks, and we found the difference in weighted F1 not significant. Our results show that fully automated IAC subtype quantification from head CT is feasible and remains robust to the use of manual and automated IAC segmentation masks. Code at this https URL.
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https://arxiv.org/abs/2609.16035
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Uni-Light: An Ultra-Lightweight Framework via Uncertainty-Aware Knowledge Distillation for Brain Tumour Segmentation
2026-09-11 07:40:12Libing Kuang, Soren Salehi, Ziling Wu, Ahmad P. Tafti, Armaghan MoemeniAbstract
Accurate 3D brain tumour segmentation from multi-modal Magnetic Resonance Imaging (MRI) is essential for clinical diagnosis and treatment planning. Existing brain tumour segmentation methods often suffer from heavy computational demands, while current lightweight architectures frequently lack the capacity to maintain segmentation fidelity in complex tumour regions. To address these issues, we propose a novel ultra-lightweight framework (Uni-Light) that achieves high-fidelity segmentation with substantially reduced computational overhead. It combines multi-scale convolutions with an uncertainty-aware knowledge distillation scheme that directs the student model toward hard-to-classify regions, complemented by a Signed Distance Field boundary loss for geometric constraints. Experimental results on BraTS2023-GLI and MSD-BTS datasets demonstrate that Uni-Light reduces parameters by 97.56%, floating-point operations (FLOPs) by 73.03%, and inference memory footprint by 81.58%, while surpassing the state-of-the-art model by an average of 1.47% in Dice score, offering a highly competitive trade-off between segmentation accuracy and computational efficiency in resource-constrained clinical settings. This work also advances data engineering for medical imaging by demonstrating that teacher model uncertainty can be exploited as a data-driven supervisory signal, re-prioritising the training data distribution without requiring additional annotation.
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https://arxiv.org/abs/2609.06729
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Bridging Vision Foundation Model Priors with CLIP for Spatial-aware Few-shot Anomaly Detection in Medical Images
2026-09-11 05:21:01Juzheng Miao, Yuchen Yuan, Cheng Chen, Pheng-Ann HengAbstract
Vision-Language Models such as CLIP enable effective few-shot medical anomaly detection (AD) via strong image-text semantic alignment. However, their globally contrastive pretraining lacks explicit spatial supervision, limiting precise lesion localization. In contrast, Vision Foundation Models (VFMs) such as DINO learn spatially coherent patch representations via self-distillation and local-to-global consistency, better capturing fine-grained anatomical structures. Leveraging this complementarity, we propose Spatial-FAD, a spatial-aware few-shot medical AD framework that improves lesion localization by combining VFM spatial priors with CLIP semantics. Specifically, we introduce a VFM-enhanced adapter that injects a structural affinity prior derived from DINO into CLIP features. This structure-guided refinement encourages visual embeddings to better adhere to lesion boundaries while maintaining semantic alignment. To address the loss of spatial detail from patchification and the limited input resolution of CLIP, we adopt a sliding-window aggregation strategy. This generates high-resolution, spatially dense embeddings to further enhance localization granularity. Moreover, we introduce a prototype-enhanced support memory scheme to efficiently exploit the few-shot support set. This module stores compact prototypes for normal and abnormal patterns, reducing memory costs while boosting performance by fusing patch-to-prototype and image-text similarities. Extensive experiments on three benchmark datasets, including Liver CT, Retinal OCT, and Brain MRI, demonstrate that Spatial-FAD significantly outperforms state-of-the-art methods, especially in lesion segmentation. Notably, in the 4-shot scenario, our method achieves an average improvement of over 11.4% in Dice score and 1.8% in AUC. Code is available at: this https URL.
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https://arxiv.org/abs/2609.12454
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HypoKG: Evidence-Disciplined Biomedical Hypothesis Generation Beyond Endpoint Knowledge
2026-09-10 22:36:02Dominic Okonkwo, Adetayo Okunoye, Ismailcem Budak ArpinarAbstract
Large language models (LLMs) can generate biomedical hypotheses, but it remains unclear whether they truly reason from scientific evidence or simply produce convincing-sounding ideas. To study this, we combine three major biological databases: the Kyoto Encyclopedia of Genes and Genomes (KEGG), Rhea, and UniProt, into a unified biochemical knowledge graph and construct a benchmark of 550 paths connecting enzyme sources to rare disease endpoints, yielding 13,200 hypotheses from six LLMs under four conditions varying the biological information each model receives: source enzyme only, full biological path, or source and disease endpoint only. Hypotheses are scored using an expert-derived five-criterion rubric on a 1-5 scale per criterion. We find that models given both the source and disease endpoint often produce the highest-scoring hypotheses, showing that LLMs can generate compelling ideas from minimal information. However, these hypotheses are less grounded in the evidence. In contrast, models given the full biological path generate hypotheses more consistent with known mechanistic relationships. We call this evidence-disciplined reasoning. To confirm this effect, we shuffled intermediate path steps while keeping endpoints fixed. Evidence grounding dropped significantly (delta = -0.793, p < 0.001), confirming models genuinely used path structure during reasoning. Our findings show that knowledge graphs support hypothesis generation in two ways: they identify biological endpoint pairs absent from the literature, and their mechanistic paths guide how LLMs reason between them.
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https://arxiv.org/abs/2609.12260
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Domain-Specific Hallucination Detection in Large Language Models
2026-09-10 17:45:36Varun Teja Chundru, Debasmita BiswasAbstract
Large language models generate fluent text that can contain unfaithful claims -- a phenomenon known as hallucination. We present a multi-signal detection pipeline combining fine-tuned DeBERTa-v3 classification, Monte Carlo (MC) Dropout uncertainty quantification, and temperature-scaled calibration for response-level hallucination detection. Evaluated on the HaluEval benchmark, our pipeline achieves F1=0.915 and AUROC=0.977 on general-domain tasks, with per-task F1 scores of 0.97 (QA), 0.96 (Summarization), and 0.82 (Dialogue). MC Dropout inference further improves accuracy to 93.2%. A context ablation study confirms the model performs genuine entailment reasoning rather than exploiting surface patterns, with summarization F1 dropping 24% when knowledge context is removed. Learning curve analysis reveals that 25% of training data captures 77% of full-data performance. Beyond detection, we apply Direct Preference Optimization (DPO) to a Qwen2.5-0.5B generator, reducing its hallucination rate from 85.5% to 37.7% (55.9% relative reduction) as measured by our detector. Cross-domain evaluation on the SciFact biomedical benchmark shows that general-domain training transfers poorly (F1=0.52), motivating domain-specific fine-tuning. PubMedBERT fine-tuned on SciFact achieves F1=0.63 and AUROC=0.81, demonstrating that domain-matched pre-training is the strongest adaptation strategy. Code and models are available at this https URL
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URL
https://arxiv.org/abs/2609.11878
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The widening evaluation gap in medical large language model research 2023 to 2026
2026-09-10 16:25:01Raad Bin Tareaf, Murad Al-Rajab, Samia LoucifAbstract
Large language models are superseded every few quarters; clinical evidence takes years. We asked whether medical research is keeping pace with the systems it evaluates. PubMed returned 11,628 records for January 2023 to June 2026 across fourteen clinical domains, growing 45-fold; 2.5% used a randomised, controlled or prospective design. Evaluation lag, from a study's newest named model release to its own publication, widened from 1.33 to 6.08 quarters. Because discontinued models age mechanically, we benchmarked this against a counterfactual holding model composition fixed: migration to newer systems offset only 56% of the drift (95% CI 50-65). Randomised trials evaluated models a median 4.6 quarters older than other designs (P = 3 x 10^-19), yet among studies naming a model still under development no design differed from any other; 62% of randomised trials evaluated a discontinued family. Rigour and currency are in tension, and that tension reflects model selection rather than research timelines.
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https://arxiv.org/abs/2609.11770
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A Comparative Evaluation of Pre-trained Convolutional Neural Networks for Melanoma Detection
2026-09-10 13:43:49Wagner Moreno Schmitz, Marco Antonio de Castro Barbosa, Thiago Magalh\~aes Amaral, Dalcimar Casanova, Jefferson Tales OlivaAbstract
Early diagnosis of melanoma is critical for improving patient survival rates. However, accurately distinguishing melanoma from other skin lesions remains a significant clinical challenge due to the high visual similarity among lesion types and variability in image acquisition conditions. Artificial intelligence, particularly machine learning, has emerged as a promising tool to support dermatological diagnosis by automating feature extraction from medical images. Among the available approaches, convolutional neural networks (CNNs) have demonstrated strong performance in image classification tasks, making them well-suited for analyzing both dermatoscopic and histopathological images, given their ability to capture hierarchical visual patterns relevant to lesion characterization. Nevertheless, despite numerous pre-trained CNN architectures having been proposed, selecting the most appropriate one for a given imaging modality remains an open challenge. In this study, we evaluate pre-trained convolutional neural networks (CNNs) for skin lesion classification using dermatoscopic and histopathological image datasets. Experiments were conducted on the HAM10000, ISIC 2018, and CR-AI4SkIN datasets, evaluating the ResNet50, VGG16, VGG19, MobileNet, and InceptionV3 architectures under the same training protocol. The experimental evaluation showed that the models achieved accuracies ranging from 71% (InceptionV3 on ISIC 2018) to 84% (ResNet50 on HAM10000) on dermatoscopic images. For histopathological images, accuracies ranged from 72% (VGG19) to 83% (ResNet50) on the CR-AI4SkIN dataset. The results demonstrate that model performance differs between dermatoscopic and histopathological image modalities, showing that architectures exhibiting similar performance on dermatoscopic images exhibit different performance on histopathological data.
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https://arxiv.org/abs/2609.11550
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Enabling Vision and Cross-Modal Learning for Multimodal Stroke Recurrence Prediction: An Interpretable Two-Step Framework
2026-09-10 13:24:05Christian Gapp, Elias Tappeiner, Martin Welk, Karl Fritscher, Stephanie Mangesius, Constantin Eisenschink, Philipp Deisl, Michael Knoflach, Astrid E. Grams, Elke R. Gizewski, Rainer SchubertAbstract
Multimodal stroke recurrence prediction requires effective integration of heterogeneous clinical and imaging data, yet modality imbalance often causes models to over-rely on dominant modalities and underutilize complementary information. While self-supervised pretraining and selective parameter freezing are commonly employed to improve representation learning and fine-tuning stability, their effect on modality contributions and cross-modal behavior in multimodal medical models remains largely unexplored. In this work, we investigate whether image pretraining on 3D CTA scans reduces modality imbalance and improves cross-modal integration for stroke recurrence prediction, a clinically critical task we recently addressed. To this end, two multimodal neural networks are pretrained in a self-supervised manner and subsequently fine-tuned using two distinct freezing strategies. Their performance and modality utilization are compared against both the baseline model from our previous work and models trained entirely from scratch in this study. Our results demonstrate that self-supervised pretraining enables more effective utilization of the multimodal image-tabular dataset, outperforming both the prior baseline and all non-pretrained models. Notably, the best-performing Vision Transformer based neural network successfully overcomes unimodal collapse. Synergy analysis reveals significant interactions between vision and both gender and CHD, suggesting clinically relevant patterns for stroke recurrence. Overall, our findings demonstrate that self-supervised pretraining and strategic fine-tuning support more balanced modality utilization and enable meaningful cross-modal interactions. Code is publicly available at this https URL.
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https://arxiv.org/abs/2609.22271
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BruNet: A Cross-Domain Transfer Framework for Bruise Segmentation
2026-09-10 12:35:20Qiming Wang, Richard J. Motley, Ebube E. Obi, Xianfang Sun, Paul L. RosinAbstract
Segmenting bruises is a challenging task in medical imaging due to limited data and annotations, diffuse boundaries, and highly variable appearance. In this work, we propose BruNet, a segmentation framework that combines a ViT-based visual encoder (a self-supervised DINOv3 or a pretrained LingBot-Vision backbone) with a SAM-based mask decoder. BruNet is trained on the HAM10000 skin lesion dataset and evaluated on a separate bruise dataset without additional fine-tuning. Although a small number of prior studies have explored machine learning and computer vision for bruise analysis, existing work has primarily focused on detection, classification, or colour analysis rather than pixel-level localisation. To the best of our knowledge, this is the first study to address automatic bruise segmentation. Our results show that BruNet outperforms CNN-based models, state-of-the-art segmentation models, ChatGPT-4o/5-assisted SAM2 zero-shot baselines, and the medical-oriented MedSAM model, demonstrating strong cross-domain generalisation to bruise segmentation.
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https://arxiv.org/abs/2609.11463
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LLMs as Post-hoc Auditors of Physiological Plausibility in Symbolic Regression: A Clinician-Evaluated Case Study
2026-09-10 12:03:33Jorge L\'opez-Varela, J. Ignacio Hidalgo, Jos\'e-Manuel Mu\~noz, Omar Costilla-Reyes, Esther Maqueda, Jesus Moreno-Fernandez, Tom\'as Gonz\'alez-Vidal, J. Manuel Velasco, Oscar GarnicaAbstract
Genetic Programming and its variants, such as grammatical evolution, are widely used in Symbolic Regression to derive mathematical expressions from multivariate data. In addition to predictive accuracy, models are appreciated for their potential to provide interpretability, offering explicit equations that relate input variables to outcomes. However, achieving interpretability and plausibility remains challenging, as evolved models may be complex or scientifically inconsistent. In this study, we explore whether Large Language Models, can assist in improving the explainability of Symbolic Regression models generated by evolutionary computation methods. Building upon our previous work on estimating body fat percentage using grammar-based Genetic Programming , we investigate the use of LLMs as post-processing tools to analyze and rank evolved expressions according to their interpretability and medical plausibility. Four symbolic expressions are analysed by three LLMs over three repeated runs, and the resulting interpretations and rankings are assessed by a panel of three clinicians. Across the three LLMs, comparative model-ranking outputs received more favorable clinician assessments than isolated term-level interpretations. However, the LLMs also produced physiologically and mathematically questionable explanations, indicating that they are better suited to comparative auditing under expert oversight than to autonomous validation.\blfootnote{The present work is an extended version of a paper submitted into a journal.
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https://arxiv.org/abs/2609.11431
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DINO-Med: A Unified Patch-Based Adaptation Framework for Multi-Modal Medical Image Analysis Applied to Liver Fibrosis Staging
2026-09-10 11:16:26Boya Wang, Ruizhe Li, Chao Chen, Xin ChenAbstract
Adapting natural-image foundation models like DINOv3 to multi-modal medical imaging is challenging due to the significant domain gap between natural color images and multi-channel medical scans. We present a unified, patch-based framework that processes raw multimodal imaging through training-free registration, automated localization, and mask-filtered patch extraction. This architecture culminates in a hierarchical strategy that aggregates patch-level insights into subject-level diagnostics. Using liver fibrosis staging as a case study, we evaluate four patch-level feature representations: handcrafted Radiomics features, learned ResNet features, pre-trained foundation model SAM-Med2D features, and frozen DINOv3 features. To ensure a controlled comparison, all models utilize the same lightweight MLP head and are evaluated across both rigid and deformable registration settings. Our training protocol focuses on mild fibrosis (S1) and cirrhosis (S4) classes only, enabling a single classifier to address both substantial fibrosis detection and cirrhosis staging. Evaluated via 10 random train (90%)/ test (10%) splits on 360 subjects from the CARE 2025 Liver Track 4 cohort, our DINOv3-based framework significantly outperforms all baselines, achieving the best classification accuracy of 78.4% for S1 and 75.8% for S4.
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https://arxiv.org/abs/2609.11380
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Your Model Already Knows Don't Teach It, Learn to Ask It: Soft Prompting for Few-Shot Adaptation of Vision-Language Models
2026-09-10 09:38:11Gautam Rajendrakumar Gare, Siyi Li, Hewei Wang, Cesar Daniel Hernandez, Wei Zhao, Wolfgang M. Pauli, John Galeotti, Deva RamananAbstract
We address few-shot object detection with vision-language models (VLMs) in out-of-domain settings such as aerial, industrial, and medical imagery, using only ten annotated images for supervision. Existing adaptation methods are discrete prompt optimization and LoRA fine-tuning. We revisit a third option: soft prompting, where a small number of continuous prompt tokens are optimized while the pretrained backbone remains frozen. We identify two key design choices. First, placing prompt tokens at the cross-modal boundary between visual and text tokens outperforms other placements (10.0 vs. 8.4 mAP). Second, initializing prompts from the empty space token outperforms semantic and random initialization. With these choices, one to three learned tokens (7,168 parameters on average) match the best LoRA configuration on Roboflow20-VL (14.2 mAP, 10-shot) while training over 20,000x fewer parameters. Soft prompting remains harder to optimize, exhibiting higher variance across random seeds. Unlike LoRA, however, it causes no forgetting: the LoRA rank matching our accuracy reduces NaturalBench VQA accuracy by 35% relative, rising to 56% at the largest rank, whereas soft prompting leaves pretrained performance unchanged. The learned tokens behave like prompts rather than weights. They transfer to a newer model without retraining (+0.8 mAP on Qwen3.5-9B) and can be verbalized into readable prompts competitive with prompt-search methods (matching DetPO and outperforming GEPA). The approach also extends beyond detection. On RoboCasa manipulation tasks, the frozen $\pi_{0.5}$ vision-language-action policy benefits from soft prompting, matching the LoRA baseline on two of three tasks when tokens are placed at the gradient bottleneck. These results suggest modern VLMs already encode much of what is needed for specialized domains; the challenge is learning how to ask.
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https://arxiv.org/abs/2609.11310
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Can LLMs Follow Medical Expert Logic? A Benchmark for Hierarchical Logical Consistency in Risk-of-Bias Assessment
2026-09-10 07:46:41Jiayu Huang, Zichen Tang, Qianhui Ling, Zemin Kuang, Haihong EAbstract
Evidence-based medicine demands strict logical consistency, yet current evaluations of large language models (LLMs) prioritize superficial label matching over genuine reasoning. We introduce LogiMed-RoB, a benchmark grounded in Cochrane Risk of Bias (RoB) 2.0 expert logic, comprising 860 randomized controlled trials (RCTs) and 14,820 queries. It evaluates models under the Hierarchical Logical Consistency (HLC) framework across four dimensions: Atomic Consistency, Domain Consistency, Aggregation Consistency, and Evidential Faithfulness. Experiments on 10 state-of-the-art LLMs reveal a catastrophic Error Compounding Effect: despite the top model reaching 98.88% Atomic Consistency, its end-to-end consistency collapses to 45.13%, with several open-weight architectures plummeting to nearly 0%. We further uncover a systematic evidence-reasoning gap: even when models retrieve high-quality evidence, they fail to deduce correct outcomes in 18.63-40.05% of cases, while Blind Guess Rates reach 48.28%. LogiMed-RoB demonstrates that high outcome accuracy can conceal critical reasoning flaws, underscoring the necessity of white-box logical verification for clinical deployment.
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https://arxiv.org/abs/2609.11185
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UniH$^3$: Unifying Hierarchical Homogeneity and Heterogeneity for All-in-One Medical Image Restoration
2026-09-10 07:02:46Zhiwen Yang, Jiayin Li, Chengyu Liu, Hui Zhang, Bingzheng Wei, Yan XuAbstract
All-in-One medical image restoration (MedIR) aims to address diverse tasks across modalities and degradation types using a single universal model. Existing methods typically prioritize modeling inter-task heterogeneity (e.g., distinct data distributions and degradation types). However, they largely neglect the inherent homogeneity present in medical images, such as widely shared anatomical structures within and across modalities, which can be leveraged to ease model training and improve generalization. To this end, we propose UniH3, a novel framework that Unifies Hierarchical Homogeneity and Heterogeneity for all-in-one medical image restoration. Specifically, to comprehensively exploit homogeneity, we introduce a Hierarchical Homogeneity Memory (H2M) module that progressively distills intra- and inter-task homogeneity priors from high-quality images during training, and adaptively retrieves the most relevant priors tailored to the input for guided restoration. These retrieved priors are then injected into the restoration pipeline via an efficient Homogeneity-Guided Attention (HGA) mechanism. Furthermore, to comprehensively address heterogeneity, we design a Hierarchical Heterogeneity Balancer (H2B) that mitigates both inter- and intra-task conflicts during optimization, facilitating balanced and effective multi-task learning. Extensive experiments on two large-scale benchmarks, MedIR-2D-500K and MedIR-3D-3K, demonstrate that UniH3 achieves state-of-the-art performance on both all-in-one and single-task medical image restoration. We hope this work establishes a strong benchmark and advances the development of general-purpose medical image restoration models. Code is available at this https URL.
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https://arxiv.org/abs/2609.11156
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Adaptive Conformal Redistribution for Inter-class Transitional Uncertainty in Medical Image Classification
2026-09-10 06:21:30Saibal Ghosh, Samarup Bhattacharya, Sanjoy Kumar Saha, Umapada Pal, Tapabrata ChakrabortiAbstract
Medical image classification is frequently complicated by transitional categories whose feature distributions overlap those of adjacent classes, producing ambiguous decision boundaries. Conformal prediction returns uncertainty-aware prediction sets, but these are not directly actionable in clinical screening, where a single decision is required. This work proposes adaptive conformal redistribution (AdaConRed), a label-free post-conformal decision rule that converts ambiguous prediction sets into refined class assignments. A five-stage pipeline is developed. Vision-language generative augmentation addresses minority-class scarcity; a frozen DermFoundation encoder provides embeddings; a lightweight multi-layer perceptron performs classification; an entropy-modulated, margin-aware nonconformity score constructs adaptive prediction sets; samples predicted as transitional with multi-label sets are reassigned to the most probable alternative class within the set, using only model outputs at inference. Evaluation uses the OSCC oral lesion and ISIC skin lesion benchmarks at a miscoverage level of 0.2. On the 3-class OSCC benchmark, overall accuracy improves from 73.54% to 77.38%, with oral cancer accuracy rising from 64.29% to 82.14% and benign accuracy from 56.57% to 70.20%. Reassignment of transitional samples reduces OPMD accuracy from 84.78% to 80.16%, consistent with the asymmetric cost of missed malignancy. On ISIC, overall accuracy improves from 85.83% to 87.19%, melanoma accuracy rising from 66.04% to 68.34%. AdaConRed outperforms LAC, APS and RAPS under an identical backbone and redistribution rule. Conformal prediction can be extended beyond uncertainty quantification toward actionable decision support where transitional disease categories are present, with gains concentrated in the clinically critical malignant categories. Code repository: this https URL.
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https://arxiv.org/abs/2609.13303
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MOSAIC: Query-Aware Exploration Policy Adaptation for GraphRAG
2026-09-10 04:12:18EunKyeong Lee, Kyeong-Jin Oh, Jinwon Kim, Hye Woo Lee, Minsang Song, Hyeongjun Jang, Junyoung YounAbstract
Graph Retrieval-Augmented Generation (GraphRAG) can connect evidence distributed across a corpus graph, but most systems use largely shared exploration procedures across queries. This creates a structural mismatch: direct facts may need compact local neighborhoods, comparisons need balanced coverage of multiple targets, and mediated questions may require deeper paths through weakly related connectors. We present Mosaic, a training-free framework that formulates GraphRAG retrieval as a per-query control problem. An LLM analyzer converts query-specific evidence requirements into a bounded policy over seed selection, graph traversal, stopping, and evidence selection, while the corpus graph, indexes, scoring functions, grounding procedure, and answer generator remain shared. On GraphRAG-Bench, Mosaic achieves query-weighted Answer Correctness of 76.97 on Medical and 64.33 on Novel, improving over the strongest previously reported overall results by 5.13 and 4.43 points. On Medical, it reaches 95.1 Evidence Recall and 86.1 Context Relevancy. Controlled comparisons on an identical graph and generator show that no fixed narrow, medium, or wide policy is consistently optimal; Mosaic improves by 9.96 points over the strongest canonical fixed policy. Relative to Fixed Wide, it evaluates 81.9% fewer paths and retains 47.2% fewer evidence items. Transfer experiments on HotpotQA, MuSiQue, and 2WikiMultiHopQA further show that the policy interface can be applied without benchmark-specific retriever training.
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https://arxiv.org/abs/2609.11065
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Meta-Learning for Classifier Selection in Image Datasets: A Feature-Driven Framework for Accuracy Prediction
2026-09-10 03:39:16Zahra Nabizadeh_Shahre_Babak, Farzaneh Koohestani, Nader Karimi, Shahram Shirani, Shadrokh SamaviAbstract
No Free Lunch theorem implies that any performance gains achieved by a classifier on a particular image distribution are necessarily offset by a loss of performance over the set of all possible problems; thus, no single model is universally optimal. Selecting the most suitable classifier for image datasets is a critical yet challenging task due to the intrinsic complexity and diversity of images. This paper proposes a meta-learning framework that leverages a comprehensive set of meta-features capturing dataset complexity to predict classifier performance without exhaustive training. By extracting and selecting features using methods such as autoencoders, pre-trained networks, and dimensionality reduction techniques, we train regression models to efficiently estimate classifier accuracies. Additionally, clustering techniques are employed to group classifiers with similar performance patterns, simplifying the recommendation process. The datasets used span a wide range of concepts, including nature, animals, numbers, motorcycles, medical images, and human bodies, to ensure broad generalization. Evaluated on 56 diverse image datasets, our approach achieves an average ranking prediction accuracy exceeding 86%, demonstrating its effectiveness in guiding model selection. This scalable and interpretable framework provides a practical solution to improve classification performance while reducing computational costs.
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https://arxiv.org/abs/2609.11041
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Exponential Pixelating Integral transform with dual fractal features for enhanced chest X-ray abnormality detection
2026-09-10 02:10:23Naveenraj Kamalakannan, Sri Ram Macharla, M Kanimozhi, M S SudhakarAbstract
The heightened prevalence of respiratory disorders, particularly exacerbated by a significant upswing in fatalities due to the novel coronavirus, underscores the critical need for early detection and timely intervention. This imperative is paramount, possessing the potential to profoundly impact and safeguard numerous lives. Medically, chest radiography stands out as an essential and economically viable medical imaging approach for diagnosing and assessing the severity of diverse Respiratory Disorders. However, their detection in Chest X-Rays is a cumbersome task even for well-trained radiologists owing to low contrast issues, overlapping of the tissue structures, subjective variability, and the presence of noise. To address these issues, a novel analytical model termed Exponential Pixelating Integral is introduced for the automatic detection of infections in Chest X-Rays in this work. Initially, the presented Exponential Pixelating Integral enhances the pixel intensities to overcome the low-contrast issues that are then polar-transformed followed by their representation using the locally invariant Mandelbrot and Julia fractal geometries for effective distinction of structural features. The collated features labeled Exponential Pixelating Integral with dually characterized fractal features are then classified by the non-parametric multivariate adaptive regression splines to establish an ensemble model between each pair of classes for effective diagnosis of diverse diseases. Rigorous analysis of the proposed classification framework on large medical benchmarked datasets showcases its superiority over its peers by registering a higher classification accuracy and F1 scores ranging from 98.46 to 99.45% and 96.53-98.10% respectively, making it a precise and interpretable automated system for diagnosing respiratory disorders.
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https://arxiv.org/abs/2609.10988
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Are We Grading Properly? Understanding Failure Modes in Medical Benchmarks
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Medical evaluation is shifting from static option-based questioning to realistic clinical scenarios with open-ended output modes. Grading these at scale naively, however, is expensive, and rubric-based evaluation has become the dominant scalable alternative. We ask what happens when the rubrics themselves are not airtight, and whether such flaws can be detected and corrected. We apply RIFT, a global rubric failure taxonomy, to two clinical benchmarks (HealthBench Professional and LiveMedBench), and find failure modes are meaningful: on HealthBench Professional an LLM judge flags 29.6% of criteria as non-atomic and 65.4% as misaligned/rigid. Then, we show that these flaws are meaningful and not simply cosmetic. As an example, rewriting bundled criteria of the form "at least one of / all of the following" as equally weighted children and regrading identical responses shifts scores by up to 15.9 percentage points on affected conversations, with disjunctive bundles inflating scores and conjunctive bundles deflating them. We also find that RIFT generally under-detects bundling on clinical rubrics, flagging 3.3% of LiveMedBench criteria as non-atomic where surface-form analysis finds structure in 25.8%.
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https://arxiv.org/abs/2609.16023
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