Classification
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Unsupervised Data Drift Monitoring for Deployed Deepfake Speech Detectors
2026-10-12 14:08:25Luk\'a\v{s} Proke\v{s}, Vojt\v{e}ch Stan\v{e}k, Anton Firc, Kamil MalinkaAbstract
Deepfake speech detectors are typically evaluated as binary classifiers on fixed benchmarks, but deployed systems face evolving attacks, codecs, speakers, and recording conditions, with labels unavailable during operation. This makes it difficult to know when a detector operates in familiar conditions and can be relied on. We propose an unsupervised drift monitor that operates on the internal embeddings of a deployed detector. The monitor compares each input against bona fide and spoof references using regularized Mahalanobis distances. These distances define trusted, ambiguous, and novel regions of the detector embedding space, allowing unfamiliar inputs to be routed for review. We evaluate the monitor on four modern detectors on three datasets. The monitor raises alerts for dataset mismatches and substantially reduces the security-critical case of accepting deepfakes at the cost of reduced automatic coverage. The results also show that drift affects both classes: bona fide recordings can move away from the training reference, increasing alert rates even in in-domain settings. Our findings suggest that deployed deepfake speech detectors should be treated not only as a binary classification, but also as a reliability problem.
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URL
https://arxiv.org/abs/2610.16826
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Predicting Audio Popularity: A Comparative Study of Metadata and Acoustic Features Across Music and Sound Effects
2026-10-12 13:55:10Ikram El Hadi, Nihad Elbari, Kawtar Tlem\c{c}ani, Th\'eo Mariotte, Meysam ShamsiAbstract
This study addresses the prediction of audio popularity on an online sharing platform by leveraging both metadata and acoustic feature representations. Two distinct categories of audio content are considered: music and sound effects. Popularity is formulated as a supervised classification task based on two target variables: the number of downloads and the average user rating. We conduct a comparative evaluation of multiple machine learning models, including Random Forest, XGBoost, and a Neural Network model. Experiments are performed across different feature sets, including metadata, platform-provided descriptors, and eGeMAPS acoustic features. Results indicate that metadata consistently provide the most informative representation for predicting popularity. Nevertheless, acoustic features alone achieve performance significantly above chance level, demonstrating that intrinsic properties of the audio signal contribute to popularity prediction.
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URL
https://arxiv.org/abs/2610.16809
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Does a Hosted Decision Model Respect Irrelevant Alternatives? A Pre-Registered Test of Option-Set Dependence in Jev
2026-10-12 12:10:32Dushyant Rajput (AltSlate Labs LLP), Nirdesh Chauhan (AltSlate Labs LLP), Siddharth Kosaraju (AltSlate Labs LLP)Abstract
Decision APIs that return a probability for each option are routinely used as if those probabilities were properties of the options themselves. That reading is valid only if the model satisfies independence of irrelevant alternatives (IIA): adding an option that is neither the right answer nor its strongest rival should leave the odds between those two unchanged. We test this in a pre-registered study of jev-1.13.0, a hosted decision model, using 299,463 calls on intent classification (BANKING77, CLINC150) and topic classification (AG News). Every added option moves the log-odds between the gold label and the strongest wrong label: the root-mean-square systematic shift is 0.20-0.52 nats, 1.2 to 3 times the run-to-run variation, even when the added option takes at most 0.1% of the probability mass. The shifts are directional. An option similar to the wrong answer draws probability from it (+0.10 nats toward the gold label). A paraphrase of the wrong answer produces an intermediate pattern: the gold label's probability is almost conserved, but the paraphrase receives only about a third of the wrong answer's share rather than the half that strict substitution implies. The distortion grows steadily with the logarithm of the number of options, reaching about 1 nat at 255 options, and off-domain padding pushes the odds against the gold label. In contrast, questions packed into one call do not interact (bias < 0.001). Scoring each option with an independent yes/no question removes the option-set dependence but picks the right answer 8.7 points less often. Jev sits between two local baselines, an option-independent scorer and a prompt readout. Its probabilities are best read as relative to the option list they were computed over.
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URL
https://arxiv.org/abs/2610.16655
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Integrating Feature Understandability into Feature Selection for Human-Centred Tabular Explanations
2026-10-12 11:44:57Nicola Rossberg, Bennett Kleinberg, Barry O'Sullivan, Luca Longo, Andrea VisentinAbstract
Existing human-centred XAI research predominantly evaluates explanations after they have been generated. However, this fails to provide actionable insights into improving accessibility. This study incorporates human-based feature understandability into feature selection to improve the generation of human-centred explanations. Natural language explanations for machine learning models trained on tabular data often cite influential features in the input data to explain a given decision. As a consequence, users' ability to understand the produced explanation hinges on their understanding of the cited features. To quantify this natural-language feature understandability, Rossberg et al. proposed the Feature Understandability Scale, which assigns numerical `understandability scores' to features based on user feedback. To evaluate the degree to which these scores can improve machine learning explanation quality, this study collects understandability scores across two datasets, proposes an understandability-aware feature selection algorithm to select features that are both understandable and informative, and trains a random forest based on these feature subsets. The SHAP-based explanations generated by this model are evaluated using user feedback, and changes in explanation quality are assessed. The individual evaluation of the explanations showed that while the understandability-based explanations scored higher on average, the difference was not statistically significant. In contrast, the comparative evaluation found that participants preferred these explanations significantly more frequently than expected at the chance level. It is concluded that the integration of understandability can yield more understandable explanations at minimal cost to classification performance, although changes to quality require elucidation in larger cohorts.
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URL
https://arxiv.org/abs/2610.16627
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DWI Connectome-based Sex Classification in Young using Supervised Variational Autoencoder
2026-10-12 08:04:44Aditya Kothapalli, Aaryan Gera, Sathvik Reddy V, Ninad Aithal, Debanjali Bhattacharya, Neelam SinhaAbstract
During adolescence, significant changes in brain development are influenced by hormonal changes that impact both the body and the brain. This study presents sex classification in 787 young adults having age range of 15-25 years using Diffusion-weighted (DWI) structural connectome, focusing on 82 Desikan-Killiany atlas ROIs. A supervised variational autoencoder (SVAE) is used to extract latent space features from DWI connectome data. Although several studies explored differences in brain structure and function between sexes, the main contribution of this study lies in incorporating SVAE to learn a compact, regularized latent representation for the task of sex classification. Initial exploratory data analysis shows that these features can capture the differences in sex-specific latent space patterns. Subsequently, the learned latent space SVAE features are fed to different ML models for sex classification. Among the considered ML classifiers, the multi-layer perceptron yields the highest accuracy of 80% in classifying sex. This demonstrates the effectiveness of SVAE in learning compact, informative representations from DWI connectome for sex classification. The present work highlights the potential of using DWI brain connectomics and deep learning to differentiate sex, paving the way for future research on diverse populations that may include transgender individuals, to better understand sex-related variations in brain structure.
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URL
https://arxiv.org/abs/2610.16348
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Rescuing Points Trapped Inside Incorrect Decision Regions: A target for Evaluating and Improving Forward-Forward Learning
2026-10-12 08:04:37Alireza Rahmansetayesh, Amirhossein Yousefiramandi, Maxwell Spiridonov, Sumit Raut, Kent Ziti, Pierre BaldiAbstract
Forward-Forward learning replaces end-to-end backpropagation with local, layer-wise training objectives. Its variants are evaluated primarily by classification accuracy, often measured with linear probes trained on their representations. We show that this evaluation can over-credit the learning method: a linear probe on the representations of an untrained convolutional neural network already reaches accuracy well above chance. Moreover, a single accuracy value does not reveal which datapoints become correctly classified after training and which remain misclassified. To examine what learning contributes beyond the random, untrained baseline, we present an analysis methodology built on the Boundary Proximity Index (BPI), a multiclass margin normalized by a class-centroid reference. We apply our analysis to seven Forward-Forward variants and related layer-local methods and find that initially misclassified points near the probe's decision boundary generally have higher rescue rates than those farther inside incorrect decision regions. Rescue rates vary substantially across methods, with some correcting a substantial fraction of these deeply embedded points. Together, these analyses offer a way to evaluate representation learning beyond accuracy and identify the rescue of points far inside incorrect decision regions as a target for improving local learning methods.
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URL
https://arxiv.org/abs/2610.16347
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Hardware-Friendly Token-Group Activation Quantization for Low-Bit Mamba Super-Resolution
2026-10-12 06:43:58Jinwoo Chung, Jangho KimAbstract
Mamba-based super-resolution models are efficient alternatives to Transformer-based restoration backbones, but their low-bit post-training quantization remains challenging because selective scan, Mamba's input-dependent state-space operator, induces different activation ranges across spatial tokens. Thus, a single layer-wise clipping range poorly matches all tokens. We propose Token-Group Quantization, a hardware-friendly activation PTQ framework that statically approximates a hardware-unfriendly post-scan grouping oracle, where tokens with similar preferred clipping ranges are assigned to the same group. To avoid runtime post-scan grouping in static low-bit inference, a lightweight predictor infers the groups from pre-scan features available before the quantized scan path. During calibration, we form pseudo-labels by clustering post-scan activation descriptors that capture similar rounding--clipping behavior. At inference, the frozen predictor maps pre-scan features to groups and selects entries from offline-calibrated group-wise clipping-bound tables, without runtime statistics collection, dynamic clipping updates, or post-scan group assignment. To address low-bit restoration degradation, we further introduce a Frequency-Preserving Refinement (FPR) objective for clipping-bound calibration. FPR aligns Fourier amplitude and phase between full-precision teacher and quantized student outputs to preserve high-frequency structures. Across PTQ protocols, bit-widths, backbones, and tasks, our method consistently outperforms prior Mamba and SR PTQ baselines, transfers to Transformer SR and Vision Mamba classification, composes with rotation-based quantization, and achieves 2.23x speedup on Jetson Orin Nano over FP16. Code is available here.
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URL
https://arxiv.org/abs/2610.16261
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Label-Centric Knowledge Retrieval for Zero-Shot Text Classification
2026-10-12 05:00:56Daoping Wu, Dong Wang, Siyu Liu, Chen Liang, Jian Geng, Ziqi Li, Shuguang Xiong, Ying ZhangAbstract
Flagship large language models (LLMs) offer rich general knowledge and strong reasoning capabilities, but their high inference cost and latency limit their use for large-scale data labeling. We study zero-shot text classification with semantically meaningful labels and task descriptions, without task-specific labeled examples or classifier feedback. We propose \textbf{SLKR} (Semantic Label Knowledge Retrieval), a label-centric retrieval-augmented generation framework that separates offline knowledge construction from lightweight online inference. Offline, a flagship LLM independently generates label definitions, retrieval keywords, and boundary rules for potentially confusable label pairs, forming a reusable label-knowledge store. Because this construction operates over the label space rather than the input corpus, its one-time flagship cost can be amortized across large-scale inference. Online, hybrid semantic and lexical retrieval first identifies the top-$K$ candidate labels and then selects up to $M$ input-relevant boundary rules connecting candidate-label pairs. A lightweight LLM performs the final classification in a single call using the retrieved definitions and rules. Across three public benchmarks and a real-world multilingual book-classification dataset, SLKR achieves the best results on all four datasets with Qwen3.5-4B and on three of four with Ministral-3-3B, while using compact input contexts and no task-specific labeled examples. Boundary ablations further show that retrieving a small set of input-relevant rules preserves performance close to using all boundaries with substantially less context, supporting efficient reuse of flagship-generated label knowledge for lightweight classification.
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URL
https://arxiv.org/abs/2610.16182
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Revocation Is Not Complete at Receipt: An Executable Outcome Contract for Distributed Agent-Tool Gateways
2026-10-11 23:41:18Lifei Liu, Haoran Yu, Danping ZhangAbstract
Distributed agent workflows cache delegated authority at tool gateways. Revocation may be reported at issuer commit, transport acknowledgment, or receiver persistence, although none of these observations establishes that all gateways enforced the change or that guarded effects stopped. We define C0-C5, a bounded outcome contract spanning issuer commit through effect prevention, and implement it as a persistent monitor over a frozen gateway set, call set, and observation window. A 14-case fault matrix checks conservative classification, sticky violations, restart persistence, and evidence immutability. In a derived audit of its eight semantic cases, treating C3 or C4 as completion produces seven or five false positives, respectively; the bounded C0-C5 verdict produces none. Descriptive scaling covers 1,024 gateways and 10,000 effect vectors. The primary experiment uses the maintained Keycloak 26.7 identity server and measures the contract across two durable receivers, eight physical agent-tool gateways, Filesystem and PostgreSQL effects, and 16 AWS hosts in three availability zones. Normal delivery and recovery commit no effects. Under receiver-selective non-delivery, transport acknowledgment and receiver persistence still succeed, but 112 of 225 calls (49.78%) are admitted, and all 112 effects commit in every treatment block. A separately provisioned execution repeats the result. OPA/Toxiproxy and a live three-role LLM workflow with networked MCP tools reproduce the persisted-but-not-enforced boundary on narrower surfaces. Finally, an unmodified external MCPMark agent executes 60 closed-loop task arms. Normal C4 denies all 31 exposed post-barrier calls and commits no effect; selective C3 allows 344 calls and commits 145 effects across Filesystem and PostgreSQL. Transport success is therefore evidence of progress, not a revocation-completion verdict.
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URL
https://arxiv.org/abs/2610.15991
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RINO: Renormalization Group Distillation with No Labels
2026-10-11 21:03:00Zichun Hao, Raghav Kansal, Abhijith Gandrakota, Chang Sun, Haoyang Li, Zihan Zhao, Ngadiuba Jennifer, Javier Duarte, Maria SpiropuluAbstract
Supervised machine learning in high-energy physics (HEP) requires training on labeled simulations of particle collisions, which are known to be unfaithful to the underlying physics. This leads to significant inaccuracies and biases in the transfer of trained models to real data, limiting the power of deep learning methods. Self-supervised learning (SSL) is a promising alternative for pretraining directly on real, unlabeled data. However, existing techniques largely operate with inductive biases inspired by domains such as images and natural language. We propose RINO (Renormalization Group DIstillation with NO Labels), which, for the first time, exploits the fundamentally multi-scale renormalization group structure of high-energy jet formation as a physically grounded source of SSL views. We define teacher-student representations across energy scales using different levels of hierarchical clustering, aligned via DINO-style self-distillation. To mirror the background-dominated nature of real collider data, RINO pretrains exclusively on jets from quantum chromodynamics (QCD) processes and is evaluated on out-of-distribution (OOD) transfer to rare signal classes. In our controlled data-efficiency study, RINO matches fully supervised training on JetNet after finetuning on only 1% of the labeled data. With the full labeled dataset, RINO improves OOD classification accuracy on top-quark jets by 5.9% and, without retraining, improves AUC on the unseen Higgs boson decay channel $H \to 4q$ by 4.1% over the strongest SSL baseline. Scale-structure diagnostics reveal that DINO-style self-distillation permits our backbone to retain scale-dependent structure. Ablation studies show that this accounts for an 8.6% OOD accuracy gap with respect to alternative SSL paradigms such as SimCLR. Code is available at this https URL.
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URL
https://arxiv.org/abs/2610.15919
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What DNA Foundation Models Learn Beyond Sequence Composition
2026-10-11 15:51:29Vincenzo Yuto Civale, Andrew David Bagdanov, Alberto MagiAbstract
Do genomic foundation models (FMs) provide predictive information beyond simple sequence composition? We evaluate frozen representations from five DNA FMs against normalized k-mer frequencies across 57 genomic classification datasets and two exploratory gene-expression regression tasks. Simple k-mer features remain competitive with most models, whereas NTv3 shows a consistent advantage; the ranking is robust to globally fixed and multi-scale k-mer baselines and alternative downstream probes. To test incremental predictive utility directly, we compare global 6-mer features with their concatenation with each FM embedding under a matched Random Forest protocol. NTv3 improves 46 of 57 datasets (mean $\Delta$MCC = +0.072), while Caduceus provides smaller gains and the other models do not improve mean MCC. We separately decompose embeddings into a component linearly predictable from 6-mer frequencies and a ridge residual, finding that linear recoverability does not reliably indicate downstream utility. Exact 6-mer-preserving shuffles further reveal task-relevant sequence-order sensitivity, most pronounced for NTv3, although order sensitivity alone does not guarantee predictive improvements. Our results establish compositional features as essential controls and offer complementary diagnostics for evaluating the added value of frozen genomic representations, without making claims about fine-tuning capacity.
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URL
https://arxiv.org/abs/2610.15711
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RespFocus: Learning Temporal Evidence for Weakly Supervised Respiratory Sound Classification
2026-10-11 15:37:56Yi Tian, Xiaohuan Chen, Yufei tang, Xinyu Lin, Hongliang Li, Chengbin Hou, Degen Huang, Rongshan YuAbstract
Respiratory auscultation provides a low-cost means of assessing pulmonary function, yet transient crackles and sustained wheezes can be difficult to recognize in noisy clinical recordings. Conventional deep learning classifiers often operate as black boxes, offering limited insight into the temporal acoustic evidence supporting their predictions. We present RespFocus, a weakly supervised framework that uses multiple instance learning (MIL) to learn inspectable temporal evidence from cycle-level labels and integrate it into classification. We also introduce PedResp2026, a multicenter pediatric respiratory sound cohort collected in routine clinical environments with adjudicated cycle-level annotations. In classification experiments, RespFocus achieves four-class Scores of 69.55\% on public ICBHI 2017 and 72.91\% on PedResp2026. Evidence diagnostics and matched temporal interventions support the functional contribution of the learned evidence to model predictions. Together, these findings highlight RespFocus's potential as a tool for automated respiratory sound diagnosis.
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URL
https://arxiv.org/abs/2610.15702
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Gugak-VocalSet: A Multi-Genre Studio-Quality Dataset of Korean Traditional Singing with Sigimsae Annotations
2026-10-11 05:14:13Danbinaerin Han, Wonil Kim, Seah Hong, Dongjoo Moon, Jaeok Lee, Jongpil Lee, Chaewon Kim, Juhan NamAbstract
We present Gugak-VocalSet, the first publicly available audio dataset for Korean traditional singing with dense annotations of sigimsae, a structured pitch contour system of vocal expressions. Gugak-VocalSet contains 24.5 hours of unaccompanied solo vocal recordings across 305 tracks of representative repertoire curated by the National Gugak Center, performed by 20 professional singers in a controlled studio environment with fixed key and tempo. In addition to genre, lyrics, and mood/timbre tags, the dataset provides a unified sigimsae ontology and approximately 68,000 segments (71,700 instances including multi-label) of audio-grounded sigimsae annotations; the ontology adopts a functional-position-based hierarchy designed for consistent application across genres, and 14 expert annotators specializing in Korean traditional music performed segment-level labeling accordingly. Baseline experiments on sigimsae classification and event detection show that domain-informed F0 representations remain competitive with, and on classification surpass, frozen probing of a general-purpose music foundation model, while pitch and spectral cues play complementary roles in event-level detection. Companion page: this https URL
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URL
https://arxiv.org/abs/2610.15350
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WisdomNet: trustable machine learning toward error-free classification
2026-10-11 03:07:31Truong X. Tran, Ramazan S. AygunAbstract
Misclassification is a critical problem in many machine learning applications. Since even the classifier models with high accuracy (e.g., > 95%) still introduce some misclassification error, it may not be possible to rely on the output of a classifier. In this paper, we introduce trustable learning, which prompts the learning model to yield only the true output, thus avoiding misclassifications. Whenever the model cannot decide the output accurately, the learning model should indicate that there could be a misclassification error if it is forced to classify, and hence, it should reject to make a decision or defer it to a human expert. Therefore, we develop a methodology for trustable learning and apply it to artificial neural networks and show that it is possible to develop a classifier with 0% misclassification error. We propose a novel neural network architecture named WisdomNet that could provide zero prediction error by introducing an additional neuron named as conjugate neuron that would indicate whether the network is able to classify the data correctly or not. The WisdomNet architecture can be applied to any previously built model, and we have evaluated WisdomNet with several network architectures such as multilayer perceptron, convolutional neural network, and deep network on different data sets. The results show that the WisdomNet is able to reduce the classification error rate to 0%, while labeling the data is difficult to classify as `reject' at a low percentage of within around 10%.
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URL
https://arxiv.org/abs/2610.15299
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OntoAR-HAR: Ontology-Guided Agentic RAG with Personalized Memory for Human Activity Recognition
2026-10-11 02:57:12Xiangqing Lu, Tao Zhu, Liang Yu, Shuangjian Li, Lulu Ban, Furong Duan, Mingxing Nie, Liming Chen, Yaping WanAbstract
LLMs increasingly support sensor-based human activity recognition (HAR) by linking motion signals with activity semantics and physical knowledge. Retrieval-augmented generation (RAG) grounds decisions in sensor examples and domain features, enabling training-free target-user inference with less dependence on raw numerical arrays. However, existing LLM/RAG-based HAR typically searches single-level activity spaces using static population knowledge. Consequently, they compare many unrelated candidates using the same static population evidence and overlook personalized motion patterns. We propose OntoAR-HAR, an ontology-guided agentic RAG framework combining static population and personalized knowledge. Its tree-structured activity ontology decomposes classification into local decisions among semantically related activities. The static store supplies node-constrained examples, while offline-discovered executable signal features provide numerical evidence for local distinctions. During inference, the personalized store collects selected user observations, which the LLM integrates with static knowledge and signal features while traversing the ontology to an activity label. Cross-subject and heterogeneous-sensing experiments show complementary gains from hierarchical retrieval and personalized memory across multiple LLM backbones, achieving state-of-the-art performance. By explicitly modeling hierarchical relations across activity granularities, OntoAR-HAR also addresses the long-overlooked semantic inclusion problem and avoids treating related labels as independent categories.
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URL
https://arxiv.org/abs/2610.15292
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Protein Crystallization Segmentation and Classification Using Subordinate Color Channel in Fluorescence Microscopy Images
2026-10-11 02:33:49Truong X. Tran, Marc L. Pusey, Ramazan S. AygunAbstract
The accuracy of detecting protein crystals for fluorescence microscopy images is very critical for high throughput and automated systems. Although the trace fluorescent labeling method could highlight protein crystals, reflection and emission from the fluorescence dye is not always due to crystal regions. Therefore, the analysis of the peak wavelength in the emission spectra of a fluorophore may not always yield effective results. In this paper, we show that using the subordinate color intensity corresponding to longer wavelengths than the peak wavelength of the emission spectra could improve the accuracy of protein crystal detection. Hence, we have built a segmentation method based on the percentile intensity of the subordinate color for trace fluorescently labeled (TFL'd) protein crystallization trial images. Compared to using the dominant color channel, our segmentation method on subordinate color channel was able to reduce the misclassification rate of likely-leads or crystals as non-crystals by the percentage of from 9.71% to 2.02% depending on the classifier. Similarly, the accuracy of classifiers were increased by the percentage of from 1.77% to 5.53%. Our method reached around 94% accuracy while keeping misclassification of likely-leads and crystals as non-crystals below 1%. Moreover, to evaluate the generalizability of our method, we have conducted new wet lab experiments on two proteins, Concanavalin A (Con A) and Ab inorganic pyrophosphate (AbIPPase), and the misclassification rate was below 1%. Our experiments show that using the subordinate channel may be more helpful for TFL'd protein trial image classification.
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URL
https://arxiv.org/abs/2610.15286
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RIECNN: Real-Time Image Enhanced CNN for Traffic Sign Recognition
2026-10-10 19:01:49Reem Abdel-Salam, Rana Mostafa, Ahmed H. Abdel-GawadAbstract
Traffic sign recognition plays a crucial role in the development of autonomous cars to reduce the accident rate and promote road safety. It has been a necessity to address traffic signs that are affected significantly by the environment as well as poor real-time performance for deep-learning state-of-the-art algorithms. In this paper, we introduce Real-Time Image Enhanced CNN ({\our}) for Traffic Sign Recognition. {\our} is a real-time, novel approach that tackles multiple, diverse traffic sign datasets, and out-performs the state-of-the-art architectures in terms of recognition rate and execution time. Experiments are conducted using the German Traffic Sign Benchmark (GTSRB), the Belgium Traffic Sign Classification (BTSC), and the Croatian Traffic Sign (rMASTIF) benchmark. Experimental results show that our approach has achieved the highest recognition rate for all Benchmarks, achieving a recognition accuracy of 99.75\% for GTSRB, 99.25\% for BTSC and 99.55\% for rMASTIF. In terms of latency and meeting the real-time constraint, the pre-processing time and inference time together do not exceed 1.3 ms per image. Not only have our proposed approach achieved remarkably high accuracy with real-time performance, but it also demonstrated robustness against traffic sign recognition challenges such as brightness and contrast variations in the environment.
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URL
https://arxiv.org/abs/2610.15127
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scHFBiMamba: a bidirectional Mamba autoencoder for cardiac disease-state classification from single-nucleus RNA-seq data
2026-10-10 18:47:11Ugo Lomoio, Pietro Hiram Guzzi, Pierangelo VeltriAbstract
To evaluate whether a compact bidirectional state-space autoencoder improves joint classification of species, cell type, and disease state from single-nucleus RNA-sequencing profiles in heart failure (HF), while yielding interpretable gene attributions. Building on the dense denoising autoencoder (DAE) and MLP framework of Ruz Jurado et al., we developed scHFBiMamba, combining a bidirectional Mamba autoencoder (BiMambaAE) with an MLP head. BiMambaAE maps 16,545-gene profiles to 350-dimensional latent representations using 13.2M parameters, about 14.6-fold fewer than the dense DAE (192.9M). We compared six encoder-classifier configurations on 38,275 held-out cardiac nuclei using McNemar tests with Benjamini-Hochberg correction, and assessed nine classifiers on frozen representations. Biological relevance was evaluated by comparing SHAP-derived differentially explained genes with differentially expressed genes against curated HF-related Gene Ontology keywords. BiMambaAE+MLP achieved the highest aggregate F1: pooled macro-F1 across 13 outputs was 0.966 versus 0.957 for DAE+MLP, and the mean category macro-F1 was 0.977 versus 0.970. It significantly improved cell-type and disease-state accuracy (adjusted p=7.1e-3 and p=4.8e-6, respectively), with species F1 of 1.000. SHAP-derived differentially explained genes achieved a pathway-enrichment benchmark F1 of 0.105 versus 0.053 for differentially expressed genes. Compact bidirectional state-space autoencoders can outperform substantially larger dense autoencoders for joint cardiac transcriptomic classification while reducing parameters. scHFBiMamba enables accurate multi-task prediction and hypothesis-generating gene-level interpretation. Code: this https URL.
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URL
https://arxiv.org/abs/2610.15117
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VLCQ: Post-training quantization for deep neural networks using variable length coding
2026-10-10 18:02:45Reem Abdel-Salam, Ahmed H. Abdel-Gawad, Amr G. WassalAbstract
Quantization plays a crucial role in efficiently deploying deep learning models on resource-constrained devices. Post-training quantization does not require access to the original dataset or retraining the full model. Current methods that achieve high performance close to baseline results typically require INT8 fixed-point integers. However, achieving higher model compression with lower bit-widths often leads to significant performance degradation. In this paper, we propose VLCQ, a post-training quantization method that relaxes the fixed-point encoding constraint, enabling more flexible exploration of quantization techniques through variable-length encoding. This approach achieves competitive or improved performance while reducing bit-widths, without requiring access to training data or model fine-tuning. Extensive experiments on image classification, segmentation, and object detection demonstrate that VLCQ improves model compression and accuracy compared with state-of-the-art post-training quantization approaches. For per-channel quantization, VLCQ surpasses FP32 accuracy and Piece-Wise Linear Quantization (PWLQ) on most evaluated models, achieving up to 6x compression compared with FP32 and up to 1.7x compared with PWLQ. When prioritizing compression with limited accuracy loss, VLCQ achieves up to 12.25x compression compared with FP32 with less than 4% performance degradation. For per-tensor quantization, VLCQ is competitive with Data-Free Quantization (DFQ), while providing greater flexibility to achieve lower bit rates across different tasks and models.
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URL
https://arxiv.org/abs/2610.15092
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Toward System One Clinical Intelligence: Parameter-Efficient Fine-Tuning and Counterfactual Explainability of Decision Foundation Models
2026-10-10 16:13:49S. M. Mahbub Uddin AhmedAbstract
Automated disease classification from patient-reported symptoms requires balancing the speed of lightweight discriminative models against the contextual understanding and latency costs of autoregressive large language models (LLMs). Decision foundation models offer an alternative by mapping representations directly to candidate classes without free-form text generation. We adapt Clef-Flash, a 9-billion-parameter decision model built on a Qwen3.5 backbone, for 24-class disease classification on the Symptom2Disease benchmark. Using 4-bit quantized low-rank adaptation (QLoRA) with differential learning rates and a stratified split of 960 training and 240 test cases, the model achieves 95.42% diagnostic accuracy and a macro F1 score of 0.9551. This improves upon the reported zero-shot baselines of 61.67% for a remote API and 65.00% for a local unadapted initialization, and outperforms the ClinicalBERT baseline (90.90%). By evaluating candidate logits in a single forward pass without autoregressive decoding, inference takes under 80 milliseconds per record on a single GPU, yielding a reported 31-fold speedup over generative LLM baselines. To examine symptom-level evidence, we introduce a Leave-One-Symptom-Out (LOSO) counterfactual perturbation framework. Removing disease-defining symptom clauses in a psoriasis example reduces predicted-class confidence from 100.00% to 0.12% and shifts the prediction to impetigo with 99.59% confidence, while removing secondary systemic symptoms produces less than 0.01% change in confidence. These findings suggest that decision-based architectures can combine the linguistic capabilities of large foundation models with low-latency inference and symptom-level interpretability for clinical triage.
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URL
https://arxiv.org/abs/2610.15029
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